about
Novel drugs that target the metabolic reprogramming in renal cell cancerα-Linolenic Acid, A Nutraceutical with Pleiotropic Properties That Targets Endogenous Neuroprotective Pathways to Protect against Organophosphate Nerve Agent-Induced NeuropathologyRegulation of the Target of Rapamycin and Other Phosphatidylinositol 3-Kinase-Related Kinases by Membrane TargetingTumor Metabolism, the Ketogenic Diet and β-Hydroxybutyrate: Novel Approaches to Adjuvant Brain Tumor TherapyStructure of the Tuberous Sclerosis Complex 2 (TSC2) N Terminus Provides Insight into Complex Assembly and Tuberous Sclerosis Pathogenesis.Inhibition of CYFIP2 promotes gastric cancer cell proliferation and chemoresistance to 5-fluorouracil through activation of the Akt signaling pathway.DAF-18/PTEN signals through AAK-1/AMPK to inhibit MPK-1/MAPK in feedback control of germline stem cell proliferationEpidermal Growth Factor Receptor Cell Proliferation Signaling PathwaysmTORC1 signalling mediates PI3K-dependent large lipid droplet accumulation in Drosophila ovarian nurse cells.Macrophage Apoptosis and Efferocytosis in the Pathogenesis of AtherosclerosisNegative regulation of EGFR signalling by the human folliculin tumour suppressor proteinPersistent mTORC1 signaling in cell senescence results from defects in amino acid and growth factor sensing.Inflammation dependent mTORC1 signaling interferes with the switch from keratinocyte proliferation to differentiation.Bone muscle crosstalk targets muscle regeneration pathway regulated by core circadian transcriptional repressors DEC1 and DEC2.Sustained activation of mTORC1 in macrophages increases AMPKα-dependent autophagy to maintain cellular homeostasisAcute hyperglycemia abolishes cardioprotection by remote ischemic perconditioning.mTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagy.The tumor suppressor PTEN and the PDK1 kinase regulate formation of the columnar neural epitheliumRole of the phosphatidylinositol-3-kinase/Akt/target of rapamycin pathway during ambidensovirus infection of insect cells.Phosphatidylinositol 3-phosphates-at the interface between cell signalling and membrane traffic.RES-529: a PI3K/AKT/mTOR pathway inhibitor that dissociates the mTORC1 and mTORC2 complexes.BEZ235: When Promising Science Meets Clinical RealityArray-CGH diagnosis in ovarian failure: identification of new molecular actors for ovarian physiology.Regulation of mTORC1 by lysosomal calcium and calmodulin.Tumor mutational analysis of GOG248, a phase II study of temsirolimus or temsirolimus and alternating megestrol acetate and tamoxifen for advanced endometrial cancer (EC): An NRG Oncology/Gynecologic Oncology Group studyIdentification of DEP domain-containing proteins by a machine learning method and experimental analysis of their expression in human HCC tissues.Computational drugs repositioning identifies inhibitors of oncogenic PI3K/AKT/P70S6K-dependent pathways among FDA-approved compounds.Intestinal Epithelial-Specific mTORC1 Activation Enhances Intestinal Adaptation After Small Bowel Resection.Nutrient-induced FNIP degradation by SCFβ-TRCP regulates FLCN complex localization and promotes renal cancer progressionPromotion Effects of miR-375 on the Osteogenic Differentiation of Human Adipose-Derived Mesenchymal Stem Cells.mTOR function and therapeutic targeting in breast cancer.Bidirectional Synaptic Structural Plasticity after Chronic Cocaine Administration Occurs through Rap1 Small GTPase Signaling.The tumor suppressor LKB1 regulates starvation-induced autophagy under systemic metabolic stress.Roles of autophagy and metabolism in pancreatic cancer cell adaptation to environmental challenges.The novel role of pyrvinium in cancer therapy.PRAS40 alleviates neurotoxic prion peptide-induced apoptosis via mTOR-AKT signaling.Targeting autophagy as a strategy for drug discovery and therapeutic modulation.Control of amino acid transport coordinates metabolic reprogramming in T-cell malignancy.Mammalian target of rapamycin complex (mTOR) pathway modulates blood-testis barrier (BTB) function through F-actin organization and gap junction.Distinct Dasatinib-Induced Mechanisms of Apoptotic Response and Exosome Release in Imatinib-Resistant Human Chronic Myeloid Leukemia Cells.
P2860
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P2860
description
2015 nî lūn-bûn
@nan
2015 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Regulation of mTORC1 by PI3K signaling
@ast
Regulation of mTORC1 by PI3K signaling
@en
Regulation of mTORC1 by PI3K signaling
@nl
type
label
Regulation of mTORC1 by PI3K signaling
@ast
Regulation of mTORC1 by PI3K signaling
@en
Regulation of mTORC1 by PI3K signaling
@nl
prefLabel
Regulation of mTORC1 by PI3K signaling
@ast
Regulation of mTORC1 by PI3K signaling
@en
Regulation of mTORC1 by PI3K signaling
@nl
P2860
P3181
P1476
Regulation of mTORC1 by PI3K signaling
@en
P2093
Lewis C. Cantley
P2860
P304
P3181
P356
10.1016/J.TCB.2015.06.002
P407
P577
2015-09-01T00:00:00Z