The pharmacological landscape and therapeutic potential of serine hydrolases - Test2 - elhamkhani - TriplyDB

The pharmacological landscape and therapeutic potential of serine hydrolases

The pharmacological landscape and therapeutic potential of serine hydrolases

http://www.wikidata.org/entity/Q26995817

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Large Scale Structural Rearrangement of a Serine Hydrolase from Francisella tularensis Facilitates Catalysis Identification of selective and potent inhibitors of fibroblast activation protein and prolyl oligopeptidase Fatty acid amide hydrolase inhibitors: a patent review (2009-2014)Mycobacterium tuberculosis Hip1 modulates macrophage responses through proteolysis of GroEL2 Novel lipid droplet-associated serine hydrolase regulates macrophage cholesterol mobilization Activity-Based Protein Profiling of Oncogene-Driven Changes in Metabolism Reveals Broad Dysregulation of PAFAH1B2 and 1B3 in Cancer.Activity-based proteomic and metabolomic approaches for understanding metabolism The N-B Interaction through a Water Bridge: Understanding the Chemoselectivity of a Fluorescent Protein Based Probe for Peroxynitrite Structure-Activity Relationships of Pentacyclic Triterpenoids as Potent and Selective Inhibitors against Human Carboxylesterase 1 Discovery libraries targeting the major enzyme classes: the serine hydrolases.Chemical approaches to therapeutically target the metabolism and signaling of the endocannabinoid 2-AG and eicosanoids Proteomic characterization of serine hydrolase activity and composition in normal urine.A genetically encoded aza-Michael acceptor for covalent cross-linking of protein-receptor complexes.Decoupled roles for the atypical, bifurcated binding pocket of the ybfF hydrolase.Chemical genetics screening reveals KIAA1363 as a cytokine-lowering target.Acyl protein thioesterase inhibitors as probes of dynamic S-palmitoylation.Identification of novel small molecules as inhibitors of hepatitis C virus by structure-based virtual screening.Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity.The evolution of Momordica cyclic peptides.Selective N-Hydroxyhydantoin Carbamate Inhibitors of Mammalian Serine Hydrolases Review seed biopharmaceutical cyclic peptides: From discovery to applications.Competitive activity-based protein profiling identifies aza-β-lactams as a versatile chemotype for serine hydrolase inhibition.Carboxylesterase 2 as a Determinant of Response to Irinotecan and Neoadjuvant FOLFIRINOX Therapy in Pancreatic Ductal Adenocarcinoma.Identification of selective covalent inhibitors of platelet activating factor acetylhydrolase 1B2 from the screening of an oxadiazolone-capped peptoid-azapeptoid hybrid library.Endocannabinoid enzyme engineering: soluble human thio-monoacylglycerol lipase (sol-S-hMGL).Serine protease inhibition by a silanediol peptidomimetic.Substrate-Competitive Activity-Based Profiling of Ester Prodrug Activating Enzymes Systematic Survey of Serine Hydrolase Activity in Mycobacterium tuberculosis Defines Changes Associated with Persistence Effects of fatty acid amide hydrolase (FAAH) inhibitors on working memory in rats.AChE Inhibition-based Multi-target-directed Ligands, a Novel Pharmacological Approach for the Symptomatic and Disease-modifying Therapy of Alzheimer's Disease.Chemical approaches to study metabolic networks Proteome-wide reactivity profiling identifies diverse carbamate chemotypes tuned for serine hydrolase inhibition.Active-site inhibitors modulate the dynamic properties of human monoacylglycerol lipase: a hydrogen exchange mass spectrometry study APEH Inhibition Affects Osteosarcoma Cell Viability via Downregulation of the Proteasome.Development and optimization of piperidyl-1,2,3-triazole ureas as selective chemical probes of endocannabinoid biosynthesis.The emerging field of chemo- and pharmacoproteomics.Prolyl oligopeptidase and its role in the organism: attention to the most promising and clinically relevant inhibitors.Chemical Genetic Approaches for the Investigation of Neutral Lipid Metabolism.Prevalence of Non-Cytochrome P450-Mediated Metabolism in Food and Drug Administration-Approved Oral and Intravenous Drugs: 2006-2015.

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The pharmacological landscape and therapeutic potential of serine hydrolases

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2012年論文

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2012年论文

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The pharmacological landscape and therapeutic potential of serine hydrolases

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The pharmacological landscape and therapeutic potential of serine hydrolases

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The pharmacological landscape and therapeutic potential of serine hydrolases

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The pharmacological landscape and therapeutic potential of serine hydrolases

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The pharmacological landscape and therapeutic potential of serine hydrolases

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The pharmacological landscape and therapeutic potential of serine hydrolases

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The pharmacological landscape and therapeutic potential of serine hydrolases

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The pharmacological landscape and therapeutic potential of serine hydrolases

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The pharmacological landscape and therapeutic potential of serine hydrolases

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Nature Reviews Drug Discovery

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The pharmacological landscape and therapeutic potential of serine hydrolases

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Benjamin F. Cravatt

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Daniel A. Bachovchin

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Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers

PME-1 protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma

A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability

Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness.

Structure of malonamidase E2 reveals a novel Ser-cisSer-Lys catalytic triad in a new serine hydrolase fold that is prevalent in nature

Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects

Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins

A specific protein carboxyl methylesterase that demethylates phosphoprotein phosphatase 2A in bovine brain

Activity-based proteomics of enzyme superfamilies: serine hydrolases as a case study

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