Somatic mutations in aging, cancer and neurodegeneration - Test2 - elhamkhani - TriplyDB

Somatic mutations in aging, cancer and neurodegeneration

Somatic mutations in aging, cancer and neurodegeneration

http://www.wikidata.org/entity/Q27000745

about

Which Is the Most Significant Cause of Aging?Diametrical diseases reflect evolutionary-genetic tradeoffs: Evidence from psychiatry, neurology, rheumatology, oncology and immunology Somatic mosaicism in the human genome Mitochondrial DNA damage patterns and aging: revising the evidences for humans and mice Preventing Alzheimer's disease by means of natural selection DNA replication error-induced extinction of diploid yeast Challenging the axiom: does the occurrence of oncogenic mutations truly limit cancer development with age?Elimination of unfit cells maintains tissue health and prolongs lifespan Additional mechanisms conferring genetic susceptibility to Alzheimer's disease Somatic mutation, genomic variation, and neurological disease Confirmation of the reported association of clonal chromosomal mosaicism with an increased risk of incident hematologic cancer The Complete Genome Sequences, Unique Mutational Spectra, and Developmental Potency of Adult Neurons Revealed by Cloning.Evaluation and clinical significance of the stomach age model for evaluating aging of the stomach-a multicenter study in China Single cell sequencing reveals low levels of aneuploidy across mammalian tissues.Detection of ultra-rare mutations by next-generation sequencing.FANCB is essential in the male germline and regulates H3K9 methylation on the sex chromosomes during meiosis.Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damage mtDNA Mutations and Their Role in Aging, Diseases and Forensic Sciences Stochastic epigenetic mutations (DNA methylation) increase exponentially in human aging and correlate with X chromosome inactivation skewing in females Genome-wide quantification of rare somatic mutations in normal human tissues using massively parallel sequencing.The Impact of Environmental and Endogenous Damage on Somatic Mutation Load in Human Skin Fibroblasts Mutational Strand Asymmetries in Cancer Genomes Reveal Mechanisms of DNA Damage and Repair.Neuropathology of cervical dystonia.Paths of Heritable Mitochondrial DNA Mutation and Heteroplasmy in Reference and gas-1 Strains of Caenorhabditis elegans.Korean Red Ginseng Tonic Extends Lifespan in D. melanogaster.Human brain harbors single nucleotide somatic variations in functionally relevant genes possibly mediated by oxidative stress.Cancer cluster investigations: review of the past and proposals for the future.Amyotrophic lateral sclerosis: a long preclinical period?End-of-life cell cycle arrest contributes to stochasticity of yeast replicative aging.Age-associated alterations in the somatic mutation and DNA methylation levels in plants.Risk Factors That Increase Risk of Estrogen Receptor-Positive and -Negative Breast Cancer.A cross-sectional case control study on genetic damage in individuals residing in the vicinity of a mobile phone base station.Non-enzymatic molecular damage as a prototypic driver of aging.Mutant TP53 disrupts age-related accumulation patterns of somatic mutations in multiple cancer types.Defining the momiome: Promiscuous information transfer by mobile mitochondria and the mitochondrial genome.An Internal Disulfide Locks a Misfolded Aggregation-prone Intermediate in Cataract-linked Mutants of Human γD-Crystallin.Functional differentiation of midbrain neurons from human cord blood-derived induced pluripotent stem cells Epidemiology of hyperadrenocorticism among 210,824 dogs attending primary-care veterinary practices in the UK from 2009 to 2014.ALS disrupts spinal motor neuron maturation and aging pathways within gene co-expression networks Mitochondrial DNA mutations increase in early stage Alzheimer disease and are inconsistent with oxidative damage.

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Somatic mutations in aging, cancer and neurodegeneration

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Somatic mutations in aging, cancer and neurodegeneration

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J.MAD.2011.10.009

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Mechanisms of Ageing and Development

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Somatic mutations in aging, cancer and neurodegeneration

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Alan J. Herr

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Lawrence A. Loeb

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Scott R. Kennedy

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P2860

Genetic variation in an individual human exome

Premature ageing in mice expressing defective mitochondrial DNA polymerase

Aneuploid neurons are functionally active and integrated into brain circuitry

Chromosomal variation in neurons of the developing and adult mammalian nervous system

The age distribution of cancer and a multi-stage theory of carcinogenesis

The TOR pathway comes of age

Evolution of the mutation rate

Mutator phenotype of Werner syndrome is characterized by extensive deletions

Human RECQ helicases: roles in DNA metabolism, mutagenesis and cancer biology

ON THE NATURE OF THE AGING PROCESS

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