Recent advances toward a molecular mechanism of efflux pump inhibition - Test2 - elhamkhani - TriplyDB

Recent advances toward a molecular mechanism of efflux pump inhibition

Recent advances toward a molecular mechanism of efflux pump inhibition

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Antimicrobial Drugs in Fighting against Antimicrobial Resistance Temperature-Dependent Gentamicin Resistance of Francisella tularensis is Mediated by Uptake Modulation.An allosteric transport mechanism for the AcrAB-TolC multidrug efflux pump Current Advances in Developing Inhibitors of Bacterial Multidrug Efflux Pumps New Structural Templates for Clinically Validated and Novel Targets in Antimicrobial Drug Research and Development.Development of selective medium for IMP-type carbapenemase-producing Enterobacteriaceae in stool specimens Genomic and phenotypic characterisation of fluoroquinolone resistance mechanisms in Enterobacteriaceae in Durban, South Africa.Mechanisms of Resistance to Aminoglycoside Antibiotics: Overview and Perspectives Permeability Barrier of Gram-Negative Cell Envelopes and Approaches To Bypass It.Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives Antimicrobial Activity and Phytochemical Analysis of Organic Extracts from Cleome spinosa Jaqc.Berberine Is a Novel Type Efflux Inhibitor Which Attenuates the MexXY-Mediated Aminoglycoside Resistance in Pseudomonas aeruginosa Design of New Antibacterial Enhancers Based on AcrB's Structure and the Evaluation of Their Antibacterial Enhancement Activity.Carbonyl Cyanide m-Chlorophenylhydrazine (CCCP) Reverses Resistance to Colistin, but Not to Carbapenems and Tigecycline in Multidrug-Resistant Enterobacteriaceae Indole-Induced Activities of β-Lactamase and Efflux Pump Confer Ampicillin Resistance in Pseudomonas putida KT2440 Pseudomonas aeruginosa: arsenal of resistance mechanisms, decades of changing resistance profiles, and future antimicrobial therapies.An overview of bacterial efflux pumps and computational approaches to study efflux pump inhibitors.Targeting efflux pumps to overcome antifungal drug resistance.Pseudomonas aeruginosa: targeting cell-wall metabolism for new antibacterial discovery and development.The analysis of the antibiotic resistome offers new opportunities for therapeutic intervention.Targeting bacterial topoisomerases: how to counter mechanisms of resistance.Multidrug efflux pumps and their role in antibiotic and antiseptic resistance: a pharmacodynamic perspective.Efflux as a mechanism of antimicrobial drug resistance in clinical relevant microorganisms: the role of efflux inhibitors.New Roads Leading to Old Destinations: Efflux Pumps as Targets to Reverse Multidrug Resistance in Bacteria.Conessine as a novel inhibitor of multidrug efflux pump systems in Pseudomonas aeruginosa.Bifunctional antimicrobial conjugates and hybrid antimicrobials.A TolC-Like Protein of Actinobacillus pleuropneumoniae Is Involved in Antibiotic Resistance and Biofilm Formation.Evidence of a Substrate-Discriminating Entrance Channel in the Lower Porter Domain of the Multidrug Resistance Efflux Pump AcrB Efflux Pump Blockers in Gram-Negative Bacteria: The New Generation of Hydantoin Based-Modulators to Improve Antibiotic Activity.Reviving Antibiotics: Efflux Pump Inhibitors That Interact with AcrA, a Membrane Fusion Protein of the AcrAB-TolC Multidrug Efflux Pump.Drug detoxification dynamics explain the postantibiotic effect.Biocide Selective TolC-Independent Efflux Pumps in Enterobacteriaceae.Thermodynamic secrets of multidrug resistance: A new take on transport mechanisms of secondary active antiporters.The prototypical proton-coupled oligopeptide transporter YdgR from Escherichia coli facilitates chloramphenicol uptake into bacterial cells.Evolution of structural fitness and multifunctional aspects of mycobacterial RND family transporters.Antimicrobial activity of six essential oils against Burkholderia cepacia complex: insights into mechanism(s) of action.Mechanisms of envelope permeability and antibiotic influx and efflux in Gram-negative bacteria.Identification and Structure-Activity Relationships of Novel Compounds that Potentiate the Activities of Antibiotics in Escherichia coli.ATP-Binding Cassette Transporter VcaM from Vibrio cholerae is Dependent on the Outer Membrane Factor Family for Its Function.Modulation of the multidrug efflux pump EmrD-3 from Vibrio cholerae by Allium sativum extract and the bioactive agent allyl sulfide plus synergistic enhancement of antimicrobial susceptibility by A. sativum extract.

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Recent advances toward a molecular mechanism of efflux pump inhibition

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Recent advances toward a molecular mechanism of efflux pump inhibition

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Recent advances toward a molecular mechanism of efflux pump inhibition

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Recent advances toward a molecular mechanism of efflux pump inhibition

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Recent advances toward a molecular mechanism of efflux pump inhibition

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Recent advances toward a molecular mechanism of efflux pump inhibition

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Recent advances toward a molecular mechanism of efflux pump inhibition

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Son T. Nguyen

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Timothy J. Opperman

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P2860

Functional rotation of the transporter AcrB: insights into drug extrusion from simulations

Drug export pathway of multidrug exporter AcrB revealed by DARPin inhibitors

Crystal structure of bacterial multidrug efflux transporter AcrB

Crystal structure of the multidrug exporter MexB from Pseudomonas aeruginosa

Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket

Crystal structure of AcrB complexed with linezolid at 3.5 Å resolution

Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop

Structure of the AcrAB–TolC multidrug efflux pump

Structural basis for the inhibition of bacterial multidrug exporters

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

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