Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration - Test2 - elhamkhani - TriplyDB

Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration

Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration

http://www.wikidata.org/entity/Q27008407

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Methods for culturing retinal pigment epithelial cells: a review of current protocols and future recommendations Relationship between Oxidative Stress, Circadian Rhythms, and AMD Inflammation and its role in age-related macular degeneration Polyphenol Stilbenes: Molecular Mechanisms of Defence against Oxidative Stress and Aging-Related Diseases βA3/A1-crystallin: more than a lens protein Amyloid properties of the leader peptide of variant B cystatin C: implications for Alzheimer and macular degeneration Circulating Autoantibodies in Age-Related Macular Degeneration Recognize Human Macular Tissue Antigens Implicated in Autophagy, Immunomodulation, and Protection from Oxidative Stress and Apoptosis Clearance of autophagy-associated dying retinal pigment epithelial cells - a possible source for inflammation in age-related macular degeneration Early AMD-like defects in the RPE and retinal degeneration in aged mice with RPE-specific deletion of Atg5 or Atg7 p62 provides dual cytoprotection against oxidative stress in the retinal pigment epithelium.Inhibition or Stimulation of Autophagy Affects Early Formation of Lipofuscin-Like Autofluorescence in the Retinal Pigment Epithelium Cell.Recent Insights into the Role of Unfolded Protein Response in ER Stress in Health and Disease.Circadian and noncircadian modulation of autophagy in photoreceptors and retinal pigment epithelium.Autophagy Regulates Proteasome Inhibitor-Induced Pigmentation in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells.Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1/βA3/A1-crystallin via V-ATPase-MTORC1 signaling.Mitochondrial oxidative stress in the retinal pigment epithelium leads to localized retinal degeneration Autophagy and mitochondrial alterations in human retinal pigment epithelial cells induced by ethanol: implications of 4-hydroxy-nonenal.Autophagy in the eye: implications for ocular cell health.Increased Lipocalin-2 in the retinal pigment epithelium of Cryba1 cKO mice is associated with a chronic inflammatory response.Autophagy activation clears ELAVL1/HuR-mediated accumulation of SQSTM1/p62 during proteasomal inhibition in human retinal pigment epithelial cells Morphological and physiological retinal degeneration induced by intravenous delivery of vitamin A dimers in rabbits.Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD Deletion of autophagy inducer RB1CC1 results in degeneration of the retinal pigment epithelium.Impairing autophagy in retinal pigment epithelium leads to inflammasome activation and enhanced macrophage-mediated angiogenesis.Photobiomodulation with 670 nm light increased phagocytosis in human retinal pigment epithelial cells Tyrosinase-Cre-Mediated Deletion of the Autophagy Gene Atg7 Leads to Accumulation of the RPE65 Variant M450 in the Retinal Pigment Epithelium of C57BL/6 Mice The marine n-3 PUFA DHA evokes cytoprotection against oxidative stress and protein misfolding by inducing autophagy and NFE2L2 in human retinal pigment epithelial cells Analysis of antioxidative factors related to AMD risk development in the polish patients.2-Phenyl-APB-144-Induced Retinal Pigment Epithelium Degeneration and Its Underlying Mechanisms Oxidative stress-mediated NFκB phosphorylation upregulates p62/SQSTM1 and promotes retinal pigmented epithelial cell survival through increased autophagy.Alpha crystallins in the retinal pigment epithelium and implications for the pathogenesis and treatment of age-related macular degeneration Differential autophagic effects of vital dyes in retinal pigment epithelial ARPE-19 and photoreceptor 661W cells Protective effect of autophagy on human retinal pigment epithelial cells against lipofuscin fluorophore A2E: implications for age-related macular degeneration Lysosomes: Regulators of autophagy in the retinal pigmented epithelium.Defects in retinal pigment epithelial cell proteolysis and the pathology associated with age-related macular degeneration.Nutraceutical with Resveratrol and Omega-3 Fatty Acids Induces Autophagy in ARPE-19 Cells.A novel AhR ligand, 2AI, protects the retina from environmental stress.Role of antioxidant enzymes and small molecular weight antioxidants in the pathogenesis of age-related macular degeneration (AMD)Dual Anti-Inflammatory and Anti-Angiogenic Action of miR-15a in Diabetic Retinopathy.Dry age-related macular degeneration: mechanisms, therapeutic targets, and imaging.

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Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration

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2013 nî lūn-bûn

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P2860

Chloroquine treatment of ARPE-19 cells leads to lysosome dilation and intracellular lipid accumulation: possible implications of lysosomal dysfunction in macular degeneration

The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

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p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

Mammalian autophagy: core molecular machinery and signaling regulation

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

CST3 genotype associated with exudative age related macular degeneration

Genetics of immunological and inflammatory components in age-related macular degeneration

Mechanisms of age-related macular degeneration

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Kai Kaarniranta

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age related macular degeneration

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