HDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs? - Test2 - elhamkhani - TriplyDB

HDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs?

HDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs?

http://www.wikidata.org/entity/Q27015801

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Emerging preclinical pharmacological targets for Parkinson's disease Targeting New Candidate Genes by Small Molecules Approaching Neurodegenerative Diseases Conformational analysis of misfolded protein aggregation by FRET and live-cell imaging techniques HDAC6 Inhibitors Rescued the Defective Axonal Mitochondrial Movement in Motor Neurons Derived from the Induced Pluripotent Stem Cells of Peripheral Neuropathy Patients with HSPB1 Mutation Differential effects of binge methamphetamine injections on the mRNA expression of histone deacetylases (HDACs) in the rat striatum HDAC6 inhibition results in tau acetylation and modulates tau phosphorylation and degradation in oligodendrocytes A Rational Approach for the Identification of Non-Hydroxamate HDAC6-Selective Inhibitors Genetic deletion of the Histone Deacetylase 6 exacerbates selected behavioral deficits in the R6/1 mouse model for Huntington's disease.Histone deacetylase 6 inhibition improves memory and reduces total tau levels in a mouse model of tau deposition.Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations.Aggresome formation is regulated by RanBPM through an interaction with HDAC6 Microtubule stabilization by Mdp3 is partially attributed to its modulation of HDAC6 in addition to its association with tubulin and microtubules.Quantification of histone deacetylase isoforms in human frontal cortex, human retina, and mouse brain Therapeutic perspectives of epigenetically active nutrients.An in vivo screen to identify candidate neurogenic genes in the developing Xenopus visual system.KLF4 regulates adult lung tumor-initiating cells and represses K-Ras-mediated lung cancer.Histone Deacetylase 6 Regulates Bladder Architecture and Host Susceptibility to Uropathogenic Escherichia coli.Effects of prenatal Poly I:C exposure on global histone deacetylase (HDAC) and DNA methyltransferase (DNMT) activity in the mouse brain Amyloid β oligomers elicit mitochondrial transport defects and fragmentation in a time-dependent and pathway-specific manner Relationships between Stress Granules, Oxidative Stress, and Neurodegenerative Diseases.Epigenetic alterations in hippocampus of SAMP8 senescent mice and modulation by voluntary physical exercise.HDAC6 regulates IL-17 expression in T lymphocytes: implications for HDAC6-targeted therapies.Inclusion body formation, macroautophagy, and the role of HDAC6 in neurodegeneration.Molecular biomarkers of neurodegeneration.Towards selective inhibition of histone deacetylase isoforms: what has been achieved, where we are and what will be next.Involvement of HDAC1 and HDAC3 in the Pathology of Polyglutamine Disorders: Therapeutic Implications for Selective HDAC1/HDAC3 Inhibitors.Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders.The role of dietary histone deacetylases (HDACs) inhibitors in health and disease.Histone deacetylase 6 in health and disease.Histone deacetylases function as a novel potential therapeutic target for cancer.Histone deacetylase 6 inhibits influenza A virus release by downregulating the trafficking of viral components to the plasma membrane via its substrate, acetylated microtubules.Microtubule Destabilization Paves the Way to Parkinson's Disease.Characterizing the "POAGome": A bioinformatics-driven approach to primary open-angle glaucoma.Accurate splicing of HDAC6 pre-mRNA requires SON Molecular dynamics of zinc-finger ubiquitin binding domains: a comparative study of histone deacetylase 6 and ubiquitin-specific protease 5.Light-Controlled Histone Deacetylase (HDAC) Inhibitors: Towards Photopharmacological Chemotherapy.Human histone deacetylase 6 shows strong preference for tubulin dimers over assembled microtubules.Histone deacetylase 6 delays motor neuron degeneration by ameliorating the autophagic flux defect in a transgenic mouse model of amyotrophic lateral sclerosis.HDAC6 mediates HIV-1 tat-induced proinflammatory responses by regulating MAPK-NF-kappaB/AP-1 pathways in astrocytes.Inhibiting histone deacetylase 6 partly protects cultured rat cortical neurons from oxygen‑glucose deprivation‑induced necroptosis.

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HDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs?

http://www.wikidata.org/entity/Q27015801

description

2013 nî lūn-bûn

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2013 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2013 թվականի հունվարին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

HDAC6 as a target for neurodeg ...... ifferent from the other HDACs?

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HDAC6 as a target for neurodeg ...... ifferent from the other HDACs?

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HDAC6 as a target for neurodeg ...... ifferent from the other HDACs?

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type

label

HDAC6 as a target for neurodeg ...... ifferent from the other HDACs?

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HDAC6 as a target for neurodeg ...... ifferent from the other HDACs?

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HDAC6 as a target for neurodeg ...... ifferent from the other HDACs?

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prefLabel

HDAC6 as a target for neurodeg ...... ifferent from the other HDACs?

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HDAC6 as a target for neurodeg ...... ifferent from the other HDACs?

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HDAC6 as a target for neurodeg ...... ifferent from the other HDACs?

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HDAC6 as a target for neurodeg ...... ifferent from the other HDACs?

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Alessandra Nurisso

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Esther Schenker

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Creative Commons Attribution 2.0 Generic

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A role for alpha-synuclein in the regulation of dopamine biosynthesis

Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family

The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress

Solution structure of the Ubp-M BUZ domain, a highly specific protein module that recognizes the C-terminal tail of free ubiquitin

HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation

Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy

Histone deacetylase 6 interacts with the microtubule-associated protein tau

The ubiquitin-like modifier FAT10 interacts with HDAC6 and localizes to aggresomes under proteasome inhibition

HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin

Histone deacetylases (HDACs): characterization of the classical HDAC family

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Claudia Simoes-Pires

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neurodegeneration

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