Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases
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The translation elongation factor eEF1A1 couples transcription to translation during heat shock responseHSF1 transcriptional activity is modulated by IER5 and PP2A/B55Protein homeostasis as a therapeutic target for diseases of protein conformationHuntington's disease: underlying molecular mechanisms and emerging conceptsStructure of human heat-shock transcription factor 1 in complex with DNAGenome-wide signatures of transcription factor activity: connecting transcription factors, disease, and small moleculesANG II promotes IGF-IIR expression and cardiomyocyte apoptosis by inhibiting HSF1 via JNK activation and SIRT1 degradationHSF1 protects neurons through a novel trimerization- and HSP-independent mechanismSIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system.Chromatin proteins: key responders to stressThe transcriptional coactivator PGC1α protects against hyperthermic stress via cooperation with the heat shock factor HSF1.The systemic amyloid precursor transthyretin (TTR) behaves as a neuronal stress protein regulated by HSF1 in SH-SY5Y human neuroblastoma cells and APP23 Alzheimer's disease model mice.Characterizing the altered cellular proteome induced by the stress-independent activation of heat shock factor 1.Proteostasis in striatal cells and selective neurodegeneration in Huntington's disease.Heat shock factor 2 is a stress-responsive mediator of neuronal migration defects in models of fetal alcohol syndromeSmall molecule activators of the heat shock response: chemical properties, molecular targets, and therapeutic promise.Genomic heat shock element sequences drive cooperative human heat shock factor 1 DNA binding and selectivity.Protein polymer nanoparticles engineered as chaperones protect against apoptosis in human retinal pigment epithelial cellsHeat shock protein-based therapy as a potential candidate for treating the sphingolipidoses.Combined pharmacological induction of Hsp70 suppresses prion protein neurotoxicity in Drosophila.Regulation of translation factor EEF1D gene function by alternative splicingA direct regulatory interaction between chaperonin TRiC and stress-responsive transcription factor HSF1.Disease-proportional proteasomal degradation of missense dystrophinsDirect link between metabolic regulation and the heat-shock response through the transcriptional regulator PGC-1α.Development-dependent regulation of molecular chaperones after hypoxia-ischemia.Diabetic peripheral neuropathy: should a chaperone accompany our therapeutic approach?Regulation of lifespan by chemosensory and thermosensory systems: findings in invertebrates and their implications in mammalian aging.Loss of function of myosin chaperones triggers Hsf1-mediated transcriptional response in skeletal muscle cells.NEDD4-mediated HSF1 degradation underlies α-synucleinopathy.Induction of heat shock protein 70 (Hsp70) prevents neuregulin-induced demyelination by enhancing the proteasomal clearance of c-Jun.Poly-glutamine expanded huntingtin dramatically alters the genome wide binding of HSF1.Mammalian Heat Shock Response and Mechanisms Underlying Its Genome-wide Transcriptional Regulation.Target- and mechanism-based therapeutics for neurodegenerative diseases: strength in numbersHeat shock proteins in the retina: Focus on HSP70 and alpha crystallins in ganglion cell survival.Gene therapy for misfolding protein diseases of the central nervous system.Heat shock factor-1 knockout enhances cholesterol 7α-hydroxylase (CYP7A1) and multidrug transporter (MDR1) gene expressions to attenuate atherosclerosis.Promoting Neuronal Tolerance of Diabetic Stress: Modulating Molecular Chaperones.Subset of heat-shock transcription factors required for the early response of Arabidopsis to excess light.Structures of HSF2 reveal mechanisms for differential regulation of human heat-shock factors.The central role of heat shock factor 1 in synaptic fidelity and memory consolidation
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Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases
description
2011 nî lūn-bûn
@nan
2011 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
name
Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases
@ast
Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases
@en
Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases
@nl
type
label
Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases
@ast
Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases
@en
Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases
@nl
prefLabel
Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases
@ast
Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases
@en
Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases
@nl
P2860
P3181
P356
P1476
Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases
@en
P2093
Alex M Jaeger
Dennis J Thiele
P2860
P2888
P304
P3181
P356
10.1038/NRD3453
P407
P577
2011-12-01T00:00:00Z
P5875
P6179
1023412745