about
Hormonal signal amplification mediates environmental conditions during development and controls an irreversible commitment to adulthoodA novel 3-hydroxysteroid dehydrogenase that regulates reproductive development and longevityIdentification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodesStructural Conservation of Ligand Binding Reveals a Bile Acid-like Signaling Pathway in NematodesA photocleavable masked nuclear-receptor ligand enables temporal control of C. elegans development.Co-option of the hormone-signalling module dafachronic acid-DAF-12 in nematode evolution.Steroids as central regulators of organismal development and lifespanA conserved endocrine mechanism controls the formation of dauer and infective larvae in nematodes.A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling.Functional divergence of dafachronic acid pathways in the control of C. elegans development and lifespan.Indicted: worms caught using steroids.Small molecule signaling in Caenorhabditis elegans.Comparative metabolomics reveals endogenous ligands of DAF-12, a nuclear hormone receptor, regulating C. elegans development and lifespan.Lipid transport and signaling in Caenorhabditis elegans.The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity.Synthesis and activity of dafachronic acid ligands for the C. elegans DAF-12 nuclear hormone receptor.Syntheses and biological evaluation of B-ring-modified analogues of dafachronic acid A.Steroid hormones controlling the life cycle of the nematode Caenorhabditis elegans: stereoselective synthesis and biology.Chemical signals synchronize the life cycles of a plant-parasitic nematode and its vector beetle.Methylation of the sterol nucleus by STRM-1 regulates dauer larva formation in Caenorhabditis elegans.Stereoselective synthesis of the hormonally active (25S)-delta7-dafachronic acid, (25S)-Delta4-dafachronic acid, (25S)-dafachronic acid, and (25S)-cholestenoic acid.Genetic identification of HSD-1, a conserved steroidogenic enzyme that directs larval development in Caenorhabditis elegans.Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans.Absolute quantification of a steroid hormone that regulates development in Caenorhabditis elegans.An efficient, stereocontrolled synthesis of the 25-(R)-diastereomer of dafachronic acid A from beta-ergosterolStereocontrolled synthesis of dafachronic acid A, the ligand for the DAF-12 nuclear receptor of Caenorhabditis elegansStereoselective synthesis and hormonal activity of novel dafachronic acids and naturally occurring steroids isolated from coralsThe Caenorhabditis elegans DAF-12 nuclear receptor: structure, dynamics, and interaction with ligands
P921
Q27319822-1617C780-0F7E-486E-8163-611E31CB3420Q27319860-DAE02701-865F-419E-8D52-398EFBC92AE0Q27655744-FA04B501-D3FF-4FA4-8A45-BD0BEB9FC51FQ27676200-1CDBA8E1-EB86-437A-BB12-D4416B755176Q33590721-919979B1-ECAC-4A6A-9687-1CA8D753113EQ34123533-C44E4A5A-86F8-4BF3-B1FC-1EA06EF0F5E2Q34233462-7392A51B-4C06-4506-A036-D09C8878D6A1Q34602464-DDB46E11-BC6D-4589-B2BA-BD6E26AF4052Q35677835-8F8A01CA-DFBE-458A-A97B-136122200411Q35879827-A610448F-4E86-40DE-9169-C24594A058DAQ36431288-731DC10D-DC0A-4BAC-993B-E9E75D1D054CQ36681183-988D6128-0198-4EDF-A8AC-BA36359FAC21Q37584863-B2BEFAB1-78BD-4574-85A2-27B67B405F15Q37691401-F5029FFD-A7BE-4787-BDB5-74322F543C44Q39508177-C0B65F83-F29C-45A1-BD71-8B029692D4ABQ39886953-E74EAB02-5A37-4441-9A8B-4B551DC454A4Q41905890-01ED512D-4BF1-462D-8DC2-A2FD8FA19B05Q43172260-9E057950-C124-44D1-90D0-CE77498DB419Q45326606-22F3D0D8-437E-4F36-8DC9-98C46C53F817Q45967116-156AD150-469A-4E81-9244-77BF483AC9A0Q46249925-88751B07-DF0E-4E87-9885-2C9CD42E44CBQ46582456-EE40986E-A955-41F7-9404-198805F9AE19Q46985126-153B4629-9B94-41DD-82A8-7FEB39BEDC84Q52643189-6E3B63A3-F9D0-4E0F-9C37-DD6A36423F78Q80626769-87DDD67F-48A7-4711-B2DF-F02B0DA34CC0Q80689494-DC83F3FE-5C10-485A-9EE4-69AD2B63FD01Q83705417-1766A74A-636A-457F-BCB9-D8118EB563F4Q83844462-A853593D-3AB9-4809-8969-C28FC010602B
P921
description
chemesch Verbindung
@lb
chemical compound
@en
chemical compound
@en-ca
chemical compound
@en-gb
chemická sloučenina
@cs
chemická zlúčenina
@sk
chemiese verbinding
@af
chemische Verbindung
@de
chemische Verbindung
@de-ch
chemische verbinding
@nl
name
(25S)-Delta(7)-dafachronic acid
@en
type
label
(25S)-Delta(7)-dafachronic acid
@en
altLabel
(+)-(25S)-3-keto-5alpha-cholest-7-en-26-oic acid
@en
(+)-(25S)-3-oxo-5alpha-cholest-7-en-26-oic acid
@en
(+)-(5alpha,25S)-3-oxocholest-7-en-26-oic acid
@en
(25S),26-3-keto-7-cholestenoic acid
@en
(25S)-3-keto-5alpha-cholest-7-en-26-oic acid
@en
(5alpha,25S)-3-oxocholest-7-en-26-oic acid
@en
Delta(7)-DA
@en
Delta(7)-dafachronic acid
@en
dafa#1
@en
dafa#2
@en
prefLabel
(25S)-Delta(7)-dafachronic acid
@en
P31
P638
P661
P662
P683
P1579
P2017
C[C@H](CCC[C@H](C)C(=O)O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3C2=CC[C@@H]4[C@@]3(CCC(=O)C4)C)C
P2063
LMST04030222
P2067
P231
949004-12-0
P233
CC(CCCC(C)C(=O)O)C1CCC2C1(CCC3C2=CCC4C3(CCC(=O)C4)C)C
P234
1S/C27H42O3/c1-17(6-5-7-18(2)2 ...... ,19+,22-,23+,24+,26+,27-/m1/s1
P235
SQTAVUCHOVVOFD-OBRBSRNPSA-N