N17 Modifies mutant Huntingtin nuclear pathogenesis and severity of disease in HD BAC transgenic mice

N17 Modifies mutant Huntingtin nuclear pathogenesis and severity of disease in HD BAC transgenic mice

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http://www.wikidata.org/entity/Q27306025
The N17 domain mitigates nuclear toxicity in a novel zebrafish Huntington's disease model.Generation and Characterization of Knock-in Mouse Models Expressing Versions of Huntingtin with Either an N17 or a Combined PolyQ and Proline-Rich Region Deletion.N-terminal Huntingtin Knock-In Mice: Implications of Removing the N-terminal Region of Huntingtin for Therapy.The 2.2-Angstrom resolution crystal structure of the carboxy-terminal region of ataxin-3.Nanoscale studies link amyloid maturity with polyglutamine diseases onset.CAG Expansions Are Genetically Stable and Form Nontoxic Aggregates in Cells Lacking Endogenous Polyglutamine ProteinsPolyglutamine expansion affects huntingtin conformation in multiple Huntington's disease models.Altered Co-Translational Processing Plays a Role in Huntington's Pathogenesis-A Hypothesis.Control of the structural landscape and neuronal proteotoxicity of mutant Huntingtin by domains flanking the polyQ tract.Altered behavioral responses to gamma-aminobutyric acid pharmacological agents in a mouse model of Huntington's disease.Phosphorylation of huntingtin at residue T3 is decreased in Huntington's disease and modulates mutant huntingtin protein conformation.Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice.Protein phosphatase 1 regulates huntingtin exon 1 aggregation and toxicity.Profilin reduces aggregation and phase separation of huntingtin N-terminal fragments by preferentially binding to soluble monomers and oligomers.Protein Misfolding in Prion and Prion-Like Diseases: Reconsidering a Required Role for Protein Loss-of-Function.Zebrafish as an Animal Model for Drug Discovery in Parkinson's Disease and Other Movement Disorders: A Systematic Review.A Fresh Look at Huntingtin mRNA Processing in Huntington's Disease.
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N17 Modifies mutant Huntingtin nuclear pathogenesis and severity of disease in HD BAC transgenic mice

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http://www.wikidata.org/entity/Q27306025
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2015 nî lūn-bûn
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2015 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2015年の論文
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2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
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2015年论文
@wuu
name
N17 Modifies mutant Huntingtin ...... ease in HD BAC transgenic mice
@ast
N17 Modifies mutant Huntingtin ...... ease in HD BAC transgenic mice
@en
N17 Modifies mutant Huntingtin ...... ease in HD BAC transgenic mice
@nl
type
label
N17 Modifies mutant Huntingtin ...... ease in HD BAC transgenic mice
@ast
N17 Modifies mutant Huntingtin ...... ease in HD BAC transgenic mice
@en
N17 Modifies mutant Huntingtin ...... ease in HD BAC transgenic mice
@nl
prefLabel
N17 Modifies mutant Huntingtin ...... ease in HD BAC transgenic mice
@ast
N17 Modifies mutant Huntingtin ...... ease in HD BAC transgenic mice
@en
N17 Modifies mutant Huntingtin ...... ease in HD BAC transgenic mice
@nl
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P3181
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P1476
N17 Modifies mutant Huntingtin ...... ease in HD BAC transgenic mice
@en
P2093
P2860
P304
P31
P3181
P356
10.1016/J.NEURON.2015.01.008
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P433
P478
P577
P698
P921
P932