Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits - Test2 - elhamkhani - TriplyDB

Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

http://www.wikidata.org/entity/Q27314989

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Tau-Centric Targets and Drugs in Clinical Development for the Treatment of Alzheimer's Disease Multiple Targets of Salicylic Acid and Its Derivatives in Plants and Animals New Features about Tau Function and Dysfunction The Metamorphic Nature of the Tau Protein: Dynamic Flexibility Comes at a Cost Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment.Tau Biology and Tau-Directed Therapies for Alzheimer's Disease Tau Structures Synaptopathies: synaptic dysfunction in neurological disorders - A review from students to students Function and regulation of tau conformations in the development and treatment of traumatic brain injury and neurodegeneration Intrinsic Tau Acetylation Is Coupled to Auto-Proteolytic Tau Fragmentation CBP/p300 Bromodomains Regulate Amyloid-like Protein Aggregation upon Aberrant Lysine Acetylation BRaf signaling principles unveiled by large-scale human mutation analysis with a rapid lentivirus-based gene replacement method.Roles of tau protein in health and disease.Dysregulation of the SIRT1/OCT6 Axis Contributes to Environmental Stress-Induced Neural Induction Defects.Role of Endoplasmic Reticulum Stress in Learning and Memory Impairment and Alzheimer's Disease-Like Neuropathology in the PS19 and APPSwe Mouse Models of Tauopathy and Amyloidosis.Neuroprotective Functions for the Histone Deacetylase SIRT6 Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss.Glycosylation and other PTMs alterations in neurodegenerative diseases: Current status and future role in neurotrauma.Reduced pCREB in Alzheimer's disease prefrontal cortex is reflected in peripheral blood mononuclear cells Therapy and clinical trials in frontotemporal dementia: past, present, and future.A Dual Pathogenic Mechanism Links Tau Acetylation to Sporadic Tauopathy.Protein misfolding in neurodegenerative diseases: implications and strategies.Tau Pathology Promotes the Reorganization of the Extracellular Matrix and Inhibits the Formation of Perineuronal Nets by Regulating the Expression and the Distribution of Hyaluronic Acid Synthases.Chemical Biology for Investigating Epigenetic Functions of Lysine Acetyltransferases (KATs).Tau and neurodegenerative disease: the story so far.Intracellular and extracellular microtubule associated protein tau as a therapeutic target in Alzheimer disease and other tauopathies.Advances in progressive supranuclear palsy: new diagnostic criteria, biomarkers, and therapeutic approaches.Tau-directed approaches for the treatment of Alzheimer's disease: focus on leuco-methylthioninium.Therapeutics Targeting Protein Acetylation Perturb Latency of Human Viruses.Pharmacological Management of Psychiatric Symptoms in Frontotemporal Dementia: A Systematic Review.SIRT1 Overexpression in Mouse Hippocampus Induces Cognitive Enhancement Through Proteostatic and Neurotrophic Mechanisms.Monoaminergic neuropathology in Alzheimer's disease.Therapeutic strategies for the treatment of tauopathies: Hopes and challenges.Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy.Acetylated tau in Alzheimer's disease: An instigator of synaptic dysfunction underlying memory loss: Increased levels of acetylated tau blocks the postsynaptic signaling required for plasticity and promotes memory deficits associated with tauopathy.Salsalate treatment following traumatic brain injury reduces inflammation and promotes a neuroprotective and neurogenic transcriptional response with concomitant functional recovery.Therapeutic Strategies for Restoring Tau Homeostasis.Epileptic activity in Alzheimer's disease: causes and clinical relevance.Signaling pathways and posttranslational modifications of tau in Alzheimer's disease: the humanization of yeast cells.

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Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

http://www.wikidata.org/entity/Q27314989

description

2015 nî lūn-bûn

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2015 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2015 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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name

Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

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Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

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Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

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Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

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Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

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Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

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Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

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Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

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Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

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Nature Medicine

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Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

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Birgit Schilling

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Bradford W Gibson

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Chao Wang

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Eliezer Masliah

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Erwin Defensor

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Jason Gestwicki

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Jeffrey Johnson

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Kotaro Shirakawa

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Li Gan

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Lisa Ellerby

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P2860

p300-dependent acetylation of activating transcription factor 5 enhances C/EBPβ transactivation of C/EBPα during 3T3-L1 differentiation

The ancient drug salicylate directly activates AMP-activated protein kinase

SIRT1 regulates HIV transcription via Tat deacetylation

Probability-based protein identification by searching sequence databases using mass spectrometry data

Neuropathological stageing of Alzheimer-related changes

Chromatin modifications and their function

Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model

Regulation of NF-kappaB action by reversible acetylation

Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation

Tau suppression in a neurodegenerative mouse model improves memory function

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1154-1162

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10.1038/NM.3951

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