Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits
about
Tau-Centric Targets and Drugs in Clinical Development for the Treatment of Alzheimer's DiseaseMultiple Targets of Salicylic Acid and Its Derivatives in Plants and AnimalsNew Features about Tau Function and DysfunctionThe Metamorphic Nature of the Tau Protein: Dynamic Flexibility Comes at a CostAcetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment.Tau Biology and Tau-Directed Therapies for Alzheimer's DiseaseTau StructuresSynaptopathies: synaptic dysfunction in neurological disorders - A review from students to studentsFunction and regulation of tau conformations in the development and treatment of traumatic brain injury and neurodegenerationIntrinsic Tau Acetylation Is Coupled to Auto-Proteolytic Tau FragmentationCBP/p300 Bromodomains Regulate Amyloid-like Protein Aggregation upon Aberrant Lysine AcetylationBRaf signaling principles unveiled by large-scale human mutation analysis with a rapid lentivirus-based gene replacement method.Roles of tau protein in health and disease.Dysregulation of the SIRT1/OCT6 Axis Contributes to Environmental Stress-Induced Neural Induction Defects.Role of Endoplasmic Reticulum Stress in Learning and Memory Impairment and Alzheimer's Disease-Like Neuropathology in the PS19 and APPSwe Mouse Models of Tauopathy and Amyloidosis.Neuroprotective Functions for the Histone Deacetylase SIRT6Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivoAcetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss.Glycosylation and other PTMs alterations in neurodegenerative diseases: Current status and future role in neurotrauma.Reduced pCREB in Alzheimer's disease prefrontal cortex is reflected in peripheral blood mononuclear cellsTherapy and clinical trials in frontotemporal dementia: past, present, and future.A Dual Pathogenic Mechanism Links Tau Acetylation to Sporadic Tauopathy.Protein misfolding in neurodegenerative diseases: implications and strategies.Tau Pathology Promotes the Reorganization of the Extracellular Matrix and Inhibits the Formation of Perineuronal Nets by Regulating the Expression and the Distribution of Hyaluronic Acid Synthases.Chemical Biology for Investigating Epigenetic Functions of Lysine Acetyltransferases (KATs).Tau and neurodegenerative disease: the story so far.Intracellular and extracellular microtubule associated protein tau as a therapeutic target in Alzheimer disease and other tauopathies.Advances in progressive supranuclear palsy: new diagnostic criteria, biomarkers, and therapeutic approaches.Tau-directed approaches for the treatment of Alzheimer's disease: focus on leuco-methylthioninium.Therapeutics Targeting Protein Acetylation Perturb Latency of Human Viruses.Pharmacological Management of Psychiatric Symptoms in Frontotemporal Dementia: A Systematic Review.SIRT1 Overexpression in Mouse Hippocampus Induces Cognitive Enhancement Through Proteostatic and Neurotrophic Mechanisms.Monoaminergic neuropathology in Alzheimer's disease.Therapeutic strategies for the treatment of tauopathies: Hopes and challenges.Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy.Acetylated tau in Alzheimer's disease: An instigator of synaptic dysfunction underlying memory loss: Increased levels of acetylated tau blocks the postsynaptic signaling required for plasticity and promotes memory deficits associated with tauopathy.Salsalate treatment following traumatic brain injury reduces inflammation and promotes a neuroprotective and neurogenic transcriptional response with concomitant functional recovery.Therapeutic Strategies for Restoring Tau Homeostasis.Epileptic activity in Alzheimer's disease: causes and clinical relevance.Signaling pathways and posttranslational modifications of tau in Alzheimer's disease: the humanization of yeast cells.
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Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits
description
2015 nî lūn-bûn
@nan
2015 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits
@ast
Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits
@en
Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits
@nl
type
label
Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits
@ast
Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits
@en
Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits
@nl
prefLabel
Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits
@ast
Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits
@en
Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits
@nl
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Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits
@en
P2093
Birgit Schilling
Bradford W Gibson
Eliezer Masliah
Erwin Defensor
Jason Gestwicki
Jeffrey Johnson
Kotaro Shirakawa
Lisa Ellerby
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P2888
P304
P3181
P356
10.1038/NM.3951
P407
P577
2015-10-01T00:00:00Z
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P6179
1041495957