Loss of UCP2 attenuates mitochondrial dysfunction without altering ROS production and uncoupling activity
about
Unraveling biochemical pathways affected by mitochondrial dysfunctions using metabolomic approaches.In the Early Stages of Diabetes, Rat Retinal Mitochondria Undergo Mild Uncoupling due to UCP2 Activity.Defective Expression of the Mitochondrial-tRNA Modifying Enzyme GTPBP3 Triggers AMPK-Mediated Adaptive Responses Involving Complex I Assembly Factors, Uncoupling Protein 2, and the Mitochondrial Pyruvate Carrier.Translocator Protein (TSPO) Affects Mitochondrial Fatty Acid Oxidation in Steroidogenic Cells.Maternal obesity reduces oxidative capacity in fetal skeletal muscle of Japanese macaques.Improved health-span and lifespan in mtDNA mutator mice treated with the mitochondrially targeted antioxidant SkQ1.PRMT1-mediated methylation of MICU1 determines the UCP2/3 dependency of mitochondrial Ca(2+) uptake in immortalized cells.Cardiac-specific down-regulation of carnitine palmitoyltransferase-1b (CPT-1b) prevents cardiac remodeling in obese mice.Targeting thermogenesis in brown fat and muscle to treat obesity and metabolic disease.Defects in the mitochondrial-tRNA modification enzymes MTO1 and GTPBP3 promote different metabolic reprogramming through a HIF-PPARγ-UCP2-AMPK axis.Mitochondrial uncoupling proteins: subtle regulators of cellular redox signaling.Deficiency of WARS2, encoding mitochondrial tryptophanyl tRNA synthetase, causes severe infantile onset leukoencephalopathy.Alteration of inflammatory cytokines, energy metabolic regulators, and muscle fiber type in the skeletal muscle of postweaning piglets.Uncoupling Protein 2 in Cardiovascular Health and DiseaseMetabolic memory in mitochondrial oxidative damage triggers diabetic retinopathyReduction in the levels of CoQ biosynthetic proteins is related to an increase in lifespan without evidence of hepatic mitohormesis
P2860
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P2860
Loss of UCP2 attenuates mitochondrial dysfunction without altering ROS production and uncoupling activity
description
2014 nî lūn-bûn
@nan
2014 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Loss of UCP2 attenuates mitoch ...... uction and uncoupling activity
@ast
Loss of UCP2 attenuates mitoch ...... uction and uncoupling activity
@en
Loss of UCP2 attenuates mitoch ...... uction and uncoupling activity
@nl
type
label
Loss of UCP2 attenuates mitoch ...... uction and uncoupling activity
@ast
Loss of UCP2 attenuates mitoch ...... uction and uncoupling activity
@en
Loss of UCP2 attenuates mitoch ...... uction and uncoupling activity
@nl
prefLabel
Loss of UCP2 attenuates mitoch ...... uction and uncoupling activity
@ast
Loss of UCP2 attenuates mitoch ...... uction and uncoupling activity
@en
Loss of UCP2 attenuates mitoch ...... uction and uncoupling activity
@nl
P2093
P2860
P50
P3181
P1433
P1476
Loss of UCP2 attenuates mitoch ...... uction and uncoupling activity
@en
P2093
Aleksandra Trifunovic
Alexandra Kukat
Alexei P Kudin
Christina Becker
Christoph Jacoby
Daniel Edgar
Daniel Ricquier
Katharina Senft
Kjell Hultenby
P2860
P304
P3181
P356
10.1371/JOURNAL.PGEN.1004385
P407
P577
2014-06-01T00:00:00Z