Heterochromatin formation promotes longevity and represses ribosomal RNA synthesis
about
Depletion of nuclear histone H2A variants is associated with chronic DNA damage signaling upon drug-evoked senescence of human somatic cellsEpigenetics and agingHypoxia-Inducible Histone Lysine Demethylases: Impact on the Aging Process and Age-Related DiseasesThe role of the ribosome in the regulation of longevity and lifespan extensionConstitutive heterochromatin formation and transcription in mammalsThe hallmarks of agingGenomic composition and evolution of Aedes aegypti chromosomes revealed by the analysis of physically mapped supercontigsRibosomal DNA copy number loss and sequence variation in cancerNatural compounds and aging: between autophagy and inflammasome.Unphosphorylated STAT5A stabilizes heterochromatin and suppresses tumor growth.2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation of aging process.Nucleolar organizer regions: genomic 'dark matter' requiring illuminationHistone methylation and aging: lessons learned from model systems.Age-associated loss of lamin-B leads to systemic inflammation and gut hyperplasia.Loss of nucleolar histone chaperone NPM1 triggers rearrangement of heterochromatin and synergizes with a deficiency in DNA methyltransferase DNMT3A to drive ribosomal DNA transcription.Long noncoding RNAs(lncRNAs) and the molecular hallmarks of aging.Transgenerational inheritance of diet-induced genome rearrangements in DrosophilaProgerin reduces LAP2α-telomere association in Hutchinson-Gilford progeria.Y chromosome mediates ribosomal DNA silencing and modulates the chromatin state in DrosophilaGlobal heterochromatin loss: a unifying theory of aging?Altered chromatin organization and SUN2 localization in mandibuloacral dysplasia are rescued by drug treatment.Life span extension by targeting a link between metabolism and histone acetylation in Drosophila.Neuronal inputs and outputs of aging and longevityProteome-wide alterations on adipose tissue from obese patients as age-, diabetes- and gender-specific hallmarksThe Aging EpigenomeTissue-specific down-regulation of S-adenosyl-homocysteine via suppression of dAhcyL1/dAhcyL2 extends health span and life span in DrosophilaInvolvement of redox state in the aging of Drosophila melanogaster.JAK-STAT in heterochromatin and genome stability.Chromatin structure and transposable elements in organismal aging.Neurodegeneration-associated instability of ribosomal DNA.The great unravelling: chromatin as a modulator of the aging process.Regulation of ribosomal gene expression in cancer.New Insights into the Regulation of Heterochromatin.BEND3 mediates transcriptional repression and heterochromatin organization.The role of hydrogen sulfide in aging and age-related pathologiesNuclear Dynamics of Heterochromatin Repair.Age-associated de-repression of retrotransposons in the Drosophila fat body, its potential cause and consequence.Assessing a peptidylic inhibitor-based therapeutic approach that simultaneously suppresses polyglutamine RNA- and protein-mediated toxicities in patient cells and Drosophila.Engrailed Homeoprotein Protects Mesencephalic Dopaminergic Neurons from Oxidative StressCanonical and non-canonical JAK/STAT transcriptional targets may be involved in distinct and overlapping cellular processes
P2860
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P2860
Heterochromatin formation promotes longevity and represses ribosomal RNA synthesis
description
2012 nî lūn-bûn
@nan
2012 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Heterochromatin formation promotes longevity and represses ribosomal RNA synthesis
@ast
Heterochromatin formation promotes longevity and represses ribosomal RNA synthesis
@en
Heterochromatin formation promotes longevity and represses ribosomal RNA synthesis
@nl
type
label
Heterochromatin formation promotes longevity and represses ribosomal RNA synthesis
@ast
Heterochromatin formation promotes longevity and represses ribosomal RNA synthesis
@en
Heterochromatin formation promotes longevity and represses ribosomal RNA synthesis
@nl
prefLabel
Heterochromatin formation promotes longevity and represses ribosomal RNA synthesis
@ast
Heterochromatin formation promotes longevity and represses ribosomal RNA synthesis
@en
Heterochromatin formation promotes longevity and represses ribosomal RNA synthesis
@nl
P2093
P2860
P3181
P1433
P1476
Heterochromatin formation promotes longevity and represses ribosomal RNA synthesis
@en
P2093
Dongdong Guo
Jacqueline Liu
Kimberly Larson
Kriti Gaur
Shian-Jang Yan
Thomas H Eickbush
Willis X Li
P2860
P304
P3181
P356
10.1371/JOURNAL.PGEN.1002473
P407
P50
P577
2012-01-26T00:00:00Z