Structure of the mycobacterial ATP synthase Fo rotor ring in complex with the anti-TB drug bedaquiline. - Test2 - elhamkhani - TriplyDB

Structure of the mycobacterial ATP synthase Fo rotor ring in complex with the anti-TB drug bedaquiline.

Structure of the mycobacterial ATP synthase Fo rotor ring in complex with the anti-TB drug bedaquiline.

http://www.wikidata.org/entity/Q27342142

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New agents for the treatment of drug-resistant Mycobacterium tuberculosis The application of tetracyclineregulated gene expression systems in the validation of novel drug targets in Mycobacterium tuberculosis Metabolic Perspectives on Persistence Purification, characterization and crystallization of the F-ATPase from Paracoccus denitrificans Cardiolipin puts the seal on ATP synthase Cardiolipin binds selectively but transiently to conserved lysine residues in the rotor of metazoan ATP synthases.Turning the respiratory flexibility of Mycobacterium tuberculosis against itself.Bedaquiline, an FDA-approved antibiotic, inhibits mitochondrial function and potently blocks the proliferative expansion of stem-like cancer cells (CSCs).Bedaquiline Targets the ε Subunit of Mycobacterial F-ATP Synthase.Structure and mechanism of the ATP synthase membrane motor inferred from quantitative integrative modeling.Structural Simplification of Bedaquiline: the Discovery of 3-(4-(N,N-Dimethylaminomethyl)phenyl)quinoline-Derived Antitubercular Lead Compounds.Oxidative Phosphorylation as a Target Space for Tuberculosis: Success, Caution, and Future Directions.The uniqueness of subunit α of mycobacterial F-ATP synthases: An evolutionary variant for niche adaptation.Mechanisms of action and therapeutic efficacies of the lipophilic antimycobacterial agents clofazimine and bedaquiline.Targeting Energy Metabolism in Mycobacterium tuberculosis, a New Paradigm in Antimycobacterial Drug Discovery.Predicted Structures of the Proton-Bound Membrane-Embedded Rotor Rings of the Saccharomyces cerevisiae and Escherichia coli ATP Synthases.Bedaquiline inhibits the ATP synthase in Mycobacterium abscessus and is effective in infected zebrafish.Molecular architecture of the N-type ATPase rotor ring from Burkholderia pseudomallei.Emergence of mmpT5 Variants during Bedaquiline Treatment of Mycobacterium intracellulare Lung Disease Antimicrobial Activity of Quinazolin Derivatives of 1,2-Di(quinazolin-4-yl)diselane against Mycobacteria.Activation of type II NADH dehydrogenase by quinolinequinones mediates antitubercular cell death.6-Cyano Analogues of Bedaquiline as Less Lipophilic and Potentially Safer Diarylquinolines for Tuberculosis.Direct assignment of 13C solid-state NMR signals of TFoF1 ATP synthase subunit c-ring in lipid membranes and its implication for the ring structure.A structure-based strategy toward the development of novel candidates for antimycobacterial activity: Synthesis, biological evaluation, and docking study.Mycobacterial Membrane Proteins QcrB and AtpE: Roles in Energetics, Antibiotic Targets, and Associated Mechanisms of Resistance.Defining Bedaquiline Susceptibility, Resistance, Cross-Resistance and Associated Genetic Determinants: A Retrospective Cohort Study.Deletion of a unique loop in the mycobacterial F-ATP synthase γ subunit sheds light on its inhibitory role in ATP hydrolysis-driven H(+) pumping.Analysis of an N-terminal deletion in subunit a of the Escherichia coli ATP synthase.Asymmetric Synthesis and Absolute Configuration Assignment of a New Type of Bedaquiline Analogue.Structure-activity relationships for analogs of the tuberculosis drug bedaquiline with the naphthalene unit replaced by bicyclic heterocycles.Tomatidine, a lead antibiotic molecule that targets Staphylococcus aureus ATP synthase subunit C.Bioenergetics of Mycobacterium: An Emerging Landscape for Drug Discovery.Insights into the regulatory function of the ɛ subunit from bacterial F-type ATP synthases: a comparison of structural, biochemical and biophysical data.A uniform cloning platform for mycobacterial genetics and protein production.

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P2860

Structure of the mycobacterial ATP synthase Fo rotor ring in complex with the anti-TB drug bedaquiline.

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2015 nî lūn-bûn

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Structure of the mycobacterial ...... the anti-TB drug bedaquiline.

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Structure of the mycobacterial ...... the anti-TB drug bedaquiline.

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Anil Koul

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Julian D Langer

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Jérôme E G Guillemont

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Laura Preiss

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Luise Eckhardt-Strelau

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Thomas Meier

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P2860

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e1500106

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10.1126/SCIADV.1500106

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26601184

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