Characterization of Hepatitis C Virus Subgenomic Replicon Resistance to Cyclosporine In Vitro - Test2 - elhamkhani - TriplyDB

Characterization of Hepatitis C Virus Subgenomic Replicon Resistance to Cyclosporine In Vitro

Characterization of Hepatitis C Virus Subgenomic Replicon Resistance to Cyclosporine In Vitro

http://www.wikidata.org/entity/Q27480361

about

Cyclosporin A associated helicase-like protein facilitates the association of hepatitis C virus RNA polymerase with its cellular cyclophilin B Hepatitis C virus NS5B and host cyclophilin A share a common binding site on NS5A A single-amino-acid mutation in hepatitis C virus NS5A disrupting FKBP8 interaction impairs viral replication Chaperones in hepatitis C virus infection Cyclophilin A Is an Essential Cofactor for Hepatitis C Virus Infection and the Principal Mediator of Cyclosporine Resistance In Vitro A Locking Mechanism Regulates RNA Synthesis and Host Protein Interaction by the Hepatitis C Virus Polymerase Combinations of Cyclophilin Inhibitor NIM811 with Hepatitis C Virus NS3-4A Protease or NS5B Polymerase Inhibitors Enhance Antiviral Activity and Suppress the Emergence of Resistance Cyclophilin B stimulates RNA synthesis by the HCV RNA dependent RNA polymerase Hepatitis C Virus NS5A Protein Is a Substrate for the Peptidyl-prolyl cis/trans Isomerase Activity of Cyclophilins A and B Critical Role of Cyclophilin A and Its Prolyl-Peptidyl Isomerase Activity in the Structure and Function of the Hepatitis C Virus Replication Complex Hepatitis C virus replicons: dinosaurs still in business?Cyclosporine Inhibits Flavivirus Replication through Blocking the Interaction between Host Cyclophilins and Viral NS5 Protein The Isomerase Active Site of Cyclophilin A Is Critical for Hepatitis C Virus Replication Mutations in the hepatitis C virus polymerase that increase RNA binding can confer resistance to cyclosporine A Hepatitis C: recent successes and continuing challenges in the development of improved treatment modalities Cyclosporine Inhibits a Direct Interaction between Cyclophilins and Hepatitis C NS5A Cyclosporin A inhibits the influenza virus replication through cyclophilin A-dependent and -independent pathways A new stochastic model for subgenomic hepatitis C virus replication considers drug resistant mutants DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A A major determinant of cyclophilin dependence and cyclosporine susceptibility of hepatitis C virus identified by a genetic approach Regulation of de novo-initiated RNA synthesis in hepatitis C virus RNA-dependent RNA polymerase by intermolecular interactions.Inhibition of dengue virus by targeting viral NS4B protein Evidence for separation of HCV subtype 1a into two distinct clades.Cyclophilin B as a co-regulator of prolactin-induced gene expression and function in breast cancer cells.Therapeutic implications of hepatitis C virus resistance to antiviral drugs.Targeting the non-structural proteins of hepatitis C virus: beyond hepatitis C virus protease and polymerase.Hepatitis C virus virology and new treatment targets.Domain 3 of NS5A protein from the hepatitis C virus has intrinsic alpha-helical propensity and is a substrate of cyclophilin A.Preexisting drug-resistance mutations reveal unique barriers to resistance for distinct antivirals A translation inhibitor that suppresses dengue virus in vitro and in vivo Hepatitis C virus-host interactions, replication, and viral assembly Hepatitis C virus inhibitor synergism suggests multistep interactions between heat-shock protein 90 and hepatitis C virus replication Cyclophilin inhibitors in hepatitis C viral infection.Expression of cyclophilin B is associated with malignant progression and regulation of genes implicated in the pathogenesis of breast cancer.Anti-HCV drugs in the pipeline.Preclinical Profile and Clinical Efficacy of a Novel Hepatitis C Virus NS5A Inhibitor, EDP-239.Review article: investigational agents for chronic hepatitis C.Short-hairpin RNAs delivered by lentiviral vector transduction trigger RIG-I-mediated IFN activation.Cellular and molecular biology of HCV infection and hepatitis.Cyclophilin inhibitors: a novel class of promising host-targeting anti-HCV agents.

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Characterization of Hepatitis C Virus Subgenomic Replicon Resistance to Cyclosporine In Vitro

http://www.wikidata.org/entity/Q27480361

description

2007 nî lūn-bûn

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2007 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2007年の論文

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2007年论文

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Characterization of Hepatitis ...... tance to Cyclosporine In Vitro

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Characterization of Hepatitis ...... tance to Cyclosporine In Vitro

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Journal of Virology

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Characterization of Hepatitis ...... tance to Cyclosporine In Vitro

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Heather B Nelson

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John M Robida

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Zhe Liu

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P2860

Cyclophilin A regulates HIV-1 infectivity, as demonstrated by gene targeting in human T cells

Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase

Robust hepatitis C virus infection in vitro.

Mutations conferring resistance to a hepatitis C virus (HCV) RNA-dependent RNA polymerase inhibitor alone or in combination with an HCV serine protease inhibitor in vitro.

Robust production of infectious hepatitis C virus (HCV) from stably HCV cDNA-transfected human hepatoma cells.

Effect of cell growth on hepatitis C virus (HCV) replication and a mechanism of cell confluence-based inhibition of HCV RNA and protein expression

Diverse Effects of Cyclosporine on Hepatitis C Virus Strain Replication

Selection and Characterization of Replicon Variants Dually Resistant to Thumb- and Palm-Binding Nonnucleoside Polymerase Inhibitors of the Hepatitis C Virus

Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus

Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site

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5829-40

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10.1128/JVI.02524-06

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11

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81

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2007-06-01T00:00:00Z

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6430208

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17376913

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1900250

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