A mutation in Irak2c identifies IRAK-2 as a central component of the TLR regulatory network of wild-derived mice
about
IRAK-2 regulates IL-1-mediated pathogenic Th17 cell development in helminthic infection.Toll-like receptor-mediated down-regulation of the deubiquitinase cylindromatosis (CYLD) protects macrophages from necroptosis in wild-derived miceA coding IRAK2 protein variant compromises Toll-like receptor (TLR) signaling and is associated with colorectal cancer survival.Human interleukin-1 receptor-associated kinase-2 is essential for Toll-like receptor-mediated transcriptional and post-transcriptional regulation of tumor necrosis factor alphaNotch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization.Mannose receptor 1 mediates cellular uptake and endosomal delivery of CpG-motif containing oligodeoxynucleotidesTwo phases of inflammatory mediator production defined by the study of IRAK2 and IRAK1 knock-in mice.Inherited human IRAK-1 deficiency selectively impairs TLR signaling in fibroblastsImiquimod has strain-dependent effects in mice and does not uniquely model human psoriasis.Two human MYD88 variants, S34Y and R98C, interfere with MyD88-IRAK4-myddosome assembly.
P2860
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P2860
A mutation in Irak2c identifies IRAK-2 as a central component of the TLR regulatory network of wild-derived mice
description
2009 nî lūn-bûn
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2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հուլիսին հրատարակված գիտական հոդված
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2009年の論文
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2009年論文
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2009年論文
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2009年論文
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2009年論文
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2009年論文
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2009年论文
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name
A mutation in Irak2c identifie ...... y network of wild-derived mice
@ast
A mutation in Irak2c identifie ...... y network of wild-derived mice
@en
A mutation in Irak2c identifie ...... y network of wild-derived mice
@nl
type
label
A mutation in Irak2c identifie ...... y network of wild-derived mice
@ast
A mutation in Irak2c identifie ...... y network of wild-derived mice
@en
A mutation in Irak2c identifie ...... y network of wild-derived mice
@nl
prefLabel
A mutation in Irak2c identifie ...... y network of wild-derived mice
@ast
A mutation in Irak2c identifie ...... y network of wild-derived mice
@en
A mutation in Irak2c identifie ...... y network of wild-derived mice
@nl
P2093
P2860
P356
P1476
A mutation in Irak2c identifie ...... y network of wild-derived mice
@en
P2093
Alexander Poltorak
Irina I Smirnova
James R Conner
P2860
P304
P356
10.1084/JEM.20090490
P407
P577
2009-07-06T00:00:00Z