Quaternary changes in topoisomerase II may direct orthogonal movement of two DNA strands
about
Structure of the N-terminal fragment of topoisomerase V reveals a new family of topoisomerases.Rotation of DNA around intact strand in human topoisomerase I implies distinct mechanisms for positive and negative supercoil relaxationmAMSA resistant human topoisomerase IIbeta mutation G465D has reduced ATP hydrolysis activity.An open conformation of the Thermus thermophilus gyrase B ATP-binding domainStructural basis for gate-DNA recognition and bending by type IIA topoisomerasesCrystal structure of DNA gyrase B' domain sheds lights on the mechanism for T-segment navigationA novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerasesA domain insertion in Escherichia coli GyrB adopts a novel fold that plays a critical role in gyrase functionStructural Insights into the Quinolone Resistance Mechanism of Mycobacterium tuberculosis DNA GyraseThe Structure of DNA-Bound Human Topoisomerase II Alpha: Conformational Mechanisms for Coordinating Inter-Subunit Interactions with DNA CleavageThe ATPase reaction cycle of yeast DNA topoisomerase II. Slow rates of ATP resynthesis and P(i) releaseOverview of protein structural and functional folds.A mutation in Escherichia coli DNA gyrase conferring quinolone resistance results in sensitivity to drugs targeting eukaryotic topoisomerase IIImportance of the fourth alpha-helix within the CAP homology domain of type II topoisomerase for DNA cleavage site recognition and quinolone action.Measurement of single macromolecule orientation by total internal reflection fluorescence polarization microscopy.Assignment of functional amino acids around the active site of human DNA topoisomerase IIalpha.Using least median of squares for structural superposition of flexible proteinsInteraction of the plasmid-encoded quinolone resistance protein Qnr with Escherichia coli DNA gyrase.Fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae: contributions of type II topoisomerase mutations and efflux to levels of resistance.A diazirine-based photoaffinity etoposide probe for labeling topoisomerase II.The C-terminal domain of DNA gyrase A adopts a DNA-bending beta-pinwheel fold.New mutation in parE in a pneumococcal in vitro mutant resistant to fluoroquinolones.Genetic analyses of mutations contributing to fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniaeThe interaction of drugs with DNA gyrase: a model for the molecular basis of quinolone action.Dual targeting of DNA gyrase and topoisomerase IV: target interactions of garenoxacin (BMS-284756, T-3811ME), a new desfluoroquinolone.Rates of gyrase supercoiling and transcription elongation control supercoil density in a bacterial chromosomeTopoisomerase targeting with and resistance to gemifloxacin in Staphylococcus aureusThe dimer state of GyrB is an active form: implications for the initial complex assembly and processive strand passage.Unlocking and opening a DNA gate.Single-molecule measurements of the opening and closing of the DNA gate by eukaryotic topoisomerase IIDNA topoisomerase II selects DNA cleavage sites based on reactivity rather than binding affinity.Probing conformational changes in human DNA topoisomerase IIα by pulsed alkylation mass spectrometry.Mechanisms of drug resistance: quinolone resistance.Position-specific trapping of topoisomerase II by benzo[a]pyrene diol epoxide adducts: implications for interactions with intercalating anticancer agents.ATP-bound conformation of topoisomerase IV: a possible target for quinolones in Streptococcus pneumoniaeTopoisomerase II drives DNA transport by hydrolyzing one ATPQuinolone-mediated bacterial death.Analysis of the eukaryotic topoisomerase II DNA gate: a single-molecule FRET and structural perspectiveStructural insight into negative DNA supercoiling by DNA gyrase, a bacterial type 2A DNA topoisomeraseDNA topoisomerases: harnessing and constraining energy to govern chromosome topology.
P2860
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P2860
Quaternary changes in topoisomerase II may direct orthogonal movement of two DNA strands
description
1999 nî lūn-bûn
@nan
1999 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Quaternary changes in topoisomerase II may direct orthogonal movement of two DNA strands
@ast
Quaternary changes in topoisomerase II may direct orthogonal movement of two DNA strands
@en
Quaternary changes in topoisomerase II may direct orthogonal movement of two DNA strands
@nl
type
label
Quaternary changes in topoisomerase II may direct orthogonal movement of two DNA strands
@ast
Quaternary changes in topoisomerase II may direct orthogonal movement of two DNA strands
@en
Quaternary changes in topoisomerase II may direct orthogonal movement of two DNA strands
@nl
prefLabel
Quaternary changes in topoisomerase II may direct orthogonal movement of two DNA strands
@ast
Quaternary changes in topoisomerase II may direct orthogonal movement of two DNA strands
@en
Quaternary changes in topoisomerase II may direct orthogonal movement of two DNA strands
@nl
P2093
P356
P1476
Quaternary changes in topoisomerase II may direct orthogonal movement of two DNA strands
@en
P2093
P356
10.1038/7556
P577
1999-04-01T00:00:00Z