Structural basis for the catalytic mechanism of a proficient enzyme: orotidine 5'-monophosphate decarboxylase
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Can sequence determine function?Crystal structures of inhibitor complexes reveal an alternate binding mode in orotidine-5'-monophosphate decarboxylaseStructural Characterization of the Molecular Events during a Slow Substrate–Product Transition in Orotidine 5′-Monophosphate DecarboxylaseMechanism of the Orotidine 5′-Monophosphate Decarboxylase-Catalyzed Reaction: Evidence for Substrate Destabilization ,Conformational Changes in Orotidine 5′-Monophosphate Decarboxylase: “Remote” Residues That Stabilize the Active ConformationThe Leishmania donovani UMP Synthase Is Essential for Promastigote Viability and Has an Unusual Tetrameric Structure That Exhibits Substrate-controlled OligomerizationFrsA functions as a cofactor-independent decarboxylase to control metabolic fluxMechanism of the Orotidine 5′-Monophosphate Decarboxylase-Catalyzed Reaction: Importance of Residues in the Orotate Binding SiteAtomic Resolution Structure of the Orotidine 5'-Monophosphate Decarboxylase Product Complex Combined with Surface Plasmon Resonance Analysis: IMPLICATIONS FOR THE CATALYTIC MECHANISMEmergent Decarboxylase Activity and Attenuation of α/β-Hydrolase Activity during the Evolution of Methylketone Biosynthesis in TomatoSubstrate Distortion Contributes to the Catalysis of Orotidine 5′-Monophosphate DecarboxylaseGene targeting in the red alga Cyanidioschyzon merolae: single- and multi-copy insertion using authentic and chimeric selection markersDevelopment and implementation of rapid metabolic engineering tools for chemical and fuel production in Geobacillus thermoglucosidasius NCIMB 11955Proton transfer from C-6 of uridine 5'-monophosphate catalyzed by orotidine 5'-monophosphate decarboxylase: formation and stability of a vinyl carbanion intermediate and the effect of a 5-fluoro substituentMechanism of OMP decarboxylation in orotidine 5'-monophosphate decarboxylase.Determination of the amino acid sequence requirements for catalysis by the highly proficient orotidine monophosphate decarboxylase.Molecular dynamic study of orotidine-5'-monophosphate decarboxylase in ground state and in intermediate state: a role of the 203-218 loop dynamics.Protein function annotation with Structurally Aligned Local Sites of Activity (SALSAs)Accelerated hydrolysis of α-halo and α-cyano pyridinium relative to uracil derivatives: a model for ODCase-catalyzed hydrolysis of 6-cyanoUMPQM/MM metadynamics study of the direct decarboxylation mechanism for orotidine-5'-monophosphate decarboxylase using two different QM regions: acceleration too small to explain rate of enzyme catalysisPolarization in the structures of uracil and thiouracils: Implication for binding with orotidine 5'-monophosphate decarboxylaseUsing catalytic atom maps to predict the catalytic functions present in enzyme active sites.Crystallization and preliminary crystallographic analysis of orotidine 5'-monophosphate decarboxylase from the human malaria parasite Plasmodium falciparum.New functional families (FunFams) in CATH to improve the mapping of conserved functional sites to 3D structures.Catalysis by orotidine 5'-monophosphate decarboxylase: effect of 5-fluoro and 4'-substituents on the decarboxylation of two-part substrates.Indiscriminate binding by orotidine 5'-phosphate decarboxylase of uridine 5'-phosphate derivatives with bulky anionic c6 substituents.Dissecting the total transition state stabilization provided by amino acid side chains at orotidine 5'-monophosphate decarboxylase: a two-part substrate approach.Stabilities of Uracil and Pyridone-Based Carbanions: A Systematic Study in the Gas Phase and Solution and Implications for the Mechanism of Orotidine-5'-Monophosphate Decarboxylase.An examination of the relationship between active site loop size and thermodynamic activation parameters for orotidine 5'-monophosphate decarboxylase from mesophilic and thermophilic organismsMolecular and Proteomic Analysis of Levofloxacin and Metronidazole Resistant Helicobacter pylori.Specificity in transition state binding: the Pauling model revisited.Catalysis in Enzymatic Decarboxylations: Comparison of Selected Cofactor-dependent and Cofactor-independent Examples.Roles for cationic residues at the quinolinic acid binding site of quinolinate phosphoribosyltransferase.Mechanism of the orotidine 5'-monophosphate decarboxylase-catalyzed reaction: effect of solvent viscosity on kinetic constants.Dissecting a charged network at the active site of orotidine-5'-phosphate decarboxylase.The identification, cloning and functional expression of the gene encoding orotidine 5'-monophosphate (OMP) decarboxylase from Plasmodium falciparum.The acidity of uracil and uracil analogs in the gas phase: four surprisingly acidic sites and biological implications.Orotidine 5'-Monophosphate Decarboxylase: Probing the Limits of the Possible for Enzyme Catalysis.
P2860
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P2860
Structural basis for the catalytic mechanism of a proficient enzyme: orotidine 5'-monophosphate decarboxylase
description
2000 nî lūn-bûn
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2000 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2000 թվականի ապրիլին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
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2000年论文
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name
Structural basis for the catal ...... 5'-monophosphate decarboxylase
@ast
Structural basis for the catal ...... 5'-monophosphate decarboxylase
@en
Structural basis for the catal ...... 5'-monophosphate decarboxylase
@nl
type
label
Structural basis for the catal ...... 5'-monophosphate decarboxylase
@ast
Structural basis for the catal ...... 5'-monophosphate decarboxylase
@en
Structural basis for the catal ...... 5'-monophosphate decarboxylase
@nl
prefLabel
Structural basis for the catal ...... 5'-monophosphate decarboxylase
@ast
Structural basis for the catal ...... 5'-monophosphate decarboxylase
@en
Structural basis for the catal ...... 5'-monophosphate decarboxylase
@nl
P356
P1433
P1476
Structural basis for the catal ...... 5'-monophosphate decarboxylase
@en
P2093
J C Navarro Poulsen
K F Jensen
P304
P356
10.1021/BI992952R
P407
P577
2000-04-18T00:00:00Z