Crystal structures of Toxoplasma gondii adenosine kinase reveal a novel catalytic mechanism and prodrug binding
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Crystal Structure of human pyridoxal kinase: structural basis of M(+) and M(2+) activationAdenosine kinase: exploitation for therapeutic gain.Crystal structure of the ADP-dependent glucokinase from Pyrococcus horikoshii at 2.0-Å resolution: A large conformational change in ADP-dependent glucokinaseConformational changes in the reaction of pyridoxal kinaseCrystal Structures of T. b. rhodesiense Adenosine Kinase Complexed with Inhibitor and Activator: Implications for Catalysis and HyperactivationChemical, genetic and structural assessment of pyridoxal kinase as a drug target in the African trypanosomeStructures of adenosine kinase fromTrypanosoma brucei bruceiAdenosine kinase from Schistosoma mansoni: structural basis for the differential incorporation of nucleoside analoguesAnalysis of the vitamin B6 biosynthesis pathway in the human malaria parasite Plasmodium falciparumOverexpression, purification and crystallographic analysis of a unique adenosine kinase from Mycobacterium tuberculosisA broad specificity nucleoside kinase from Thermoplasma acidophilumMolecular characterization of Chinese hamster cells mutants affected in adenosine kinase and showing novel genetic and biochemical characteristics.Functional analysis of the glycero-manno-heptose 7-phosphate kinase domain from the bifunctional HldE protein, which is involved in ADP-L-glycero-D-manno-heptose biosynthesis.Common hydrogen bond interactions in diverse phosphoryl transfer active sites.Genetic variation in the adenosine regulatory cycle is associated with posttraumatic epilepsy developmentSynthesis, biological evaluation and molecular modeling studies of N6-benzyladenosine analogues as potential anti-toxoplasma agents.Adenosine kinase of Trypanosoma brucei and its role in susceptibility to adenosine antimetabolites.New antibacterials for the treatment of toxoplasmosis; a patent review.Structure-activity relationship for adenosine kinase from Mycobacterium tuberculosis II. Modifications to the ribofuranosyl moiety.Crystal structure of pyridoxal kinase from the Escherichia coli pdxK gene: implications for the classification of pyridoxal kinases.Expression, purification, crystallization and preliminary X-ray analysis of a nucleoside kinase from the hyperthermophile Methanocaldococcus jannaschii.Homology-model-guided site-specific mutagenesis reveals the mechanisms of substrate binding and product-regulation of adenosine kinase from Leishmania donovani.Mutational analysis of the active-site residues crucial for catalytic activity of adenosine kinase from Leishmania donovani.An uncharacterized member of the ribokinase family in Thermococcus kodakarensis exhibits myo-inositol kinase activity.A single-domain cyclophilin from Leishmania donovani reactivates soluble aggregates of adenosine kinase by isomerase-independent chaperone function.Expression in Escherichia coli of a recombinant adenosine kinase from Saccharomyces cerevisiae: purification, kinetics and substrate analyses.A phosphofructokinase B-type carbohydrate kinase family protein, NARA5, for massive expressions of plastid-encoded photosynthetic genes in Arabidopsis.A novel nucleoside kinase from Burkholderia thailandensis: a member of the phosphofructokinase B-type family of enzymes.Specificity evolution of the ADP-dependent sugar kinase family: in silico studies of the glucokinase/phosphofructokinase bifunctional enzyme from Methanocaldococcus jannaschii.Evolution of the genetic code by incorporation of amino acids that improved or changed protein function.Adenosine Kinase couples sensing of cellular potassium depletion to purine metabolism
P2860
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P2860
Crystal structures of Toxoplasma gondii adenosine kinase reveal a novel catalytic mechanism and prodrug binding
description
2000 nî lūn-bûn
@nan
2000 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Crystal structures of Toxoplas ...... mechanism and prodrug binding
@ast
Crystal structures of Toxoplas ...... mechanism and prodrug binding
@en
Crystal structures of Toxoplas ...... mechanism and prodrug binding
@nl
type
label
Crystal structures of Toxoplas ...... mechanism and prodrug binding
@ast
Crystal structures of Toxoplas ...... mechanism and prodrug binding
@en
Crystal structures of Toxoplas ...... mechanism and prodrug binding
@nl
prefLabel
Crystal structures of Toxoplas ...... mechanism and prodrug binding
@ast
Crystal structures of Toxoplas ...... mechanism and prodrug binding
@en
Crystal structures of Toxoplas ...... mechanism and prodrug binding
@nl
P2093
P356
P1476
Crystal structures of Toxoplas ...... mechanism and prodrug binding
@en
P2093
I I Mathews
M A Schumacher
R G Brennan
S E Ealick
P304
P356
10.1006/JMBI.2000.3753
P407
P577
2000-05-19T00:00:00Z