The productive conformation of arachidonic acid bound to prostaglandin synthase
about
Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factorsEnzymes of the cyclooxygenase pathways of prostanoid biosynthesisHuman cyclooxygenase-2 is a sequence homodimer that functions as a conformational heterodimerLeucine/valine residues direct oxygenation of linoleic acid by (10R)- and (8R)-dioxygenases: expression and site-directed mutagenesis oF (10R)-dioxygenase with epoxyalcohol synthase activityStructural basis for substrate fatty acyl chain specificity: crystal structure of human very-long-chain acyl-CoA dehydrogenaseNitro-fatty acids: novel anti-inflammatory lipid mediatorsOxicams, a class of nonsteroidal anti-inflammatory drugs and beyondMutational and X-ray crystallographic analysis of the interaction of dihomo-gamma -linolenic acid with prostaglandin endoperoxide H synthasesStructure of eicosapentaenoic and linoleic acids in the cyclooxygenase site of prostaglandin endoperoxide H synthase-1A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385Structural basis of enantioselective inhibition of cyclooxygenase-1 by S-alpha-substituted indomethacin ethanolamidesCoxibs interfere with the action of aspirin by binding tightly to one monomer of cyclooxygenase-1Structural Basis of Fatty Acid Substrate Binding to Cyclooxygenase-2Comparison of Cyclooxygenase-1 Crystal Structures: Cross-Talk between Monomers Comprising Cyclooxygenase-1 Homodimers,The Structural Basis of Endocannabinoid Oxygenation by Cyclooxygenase-2A Binding Site for Nonsteroidal Anti-inflammatory Drugs in Fatty Acid Amide HydrolaseThe Crystal Structure of α-Dioxygenase Provides Insight into Diversity in the Cyclooxygenase-Peroxidase SuperfamilyInvestigating Substrate Promiscuity in Cyclooxygenase-2: THE ROLE OF ARG-120 AND RESIDUES LINING THE HYDROPHOBIC GROOVECrystal structures of α-dioxygenase fromOryza sativa: Insights into substrate binding and activation by hydrogen peroxideOxicams Bind in a Novel Mode to the Cyclooxygenase Active Site via a Two-water-mediated H-bonding NetworkThe cardiovascular toxicity of selective and nonselective cyclooxygenase inhibitors: comparisons, contrasts, and aspirin confoundingUnorthodox routes to prostanoid formation: new twists in cyclooxygenase-initiated pathwaysControl of prostaglandin stereochemistry at the 15-carbon by cyclooxygenases-1 and -2. A critical role for serine 530 and valine 349The role of COX-1 and COX-2 in asthma pathogenesis and its significance in the use of selective inhibitorsStructural characterization of arachidonyl radicals formed by aspirin-treated prostaglandin H synthase-2Role of Tyr348 in Tyr385 radical dynamics and cyclooxygenase inhibitor interactions in prostaglandin H synthase-2Molecular dynamics simulations of arachidonic acid complexes with COX-1 and COX-2: insights into equilibrium behaviorMolecular dynamics simulations of arachidonic acid-derived pentadienyl radical intermediate complexes with COX-1 and COX-2: insights into oxygenation regio- and stereoselectivityHydrophobic ligand binding by Zn-alpha 2-glycoprotein, a soluble fat-depleting factor related to major histocompatibility complex proteinsOxidation of 4-chlorobiphenyl metabolites to electrophilic species by prostaglandin H synthaseStructural basis for certain naturally occurring bioflavonoids to function as reducing co-substrates of cyclooxygenase I and IIKeys to Lipid Selection in Fatty Acid Amide Hydrolase Catalysis: Structural Flexibility, Gating Residues and Multiple Binding PocketsFluorescence of tryptophan in designed hairpin and Trp-cage miniproteins: measurements of fluorescence yields and calculations by quantum mechanical molecular dynamics simulations.Insights from biophysical studies on the role of polyunsaturated fatty acids for function of G-protein coupled membrane receptors.Characterization of an AM404 analogue, N-(3-hydroxyphenyl)arachidonoylamide, as a substrate and inactivator of prostaglandin endoperoxide synthase.Role of glycosylation and membrane environment in nicotinic acetylcholine receptor stability.Heme enzyme structure and function.Partnering between monomers of cyclooxygenase-2 homodimersA critical role of non-active site residues on cyclooxygenase helices 5 and 6 in the control of prostaglandin stereochemistry at carbon 15.Nitroarachidonic acid, a novel peroxidase inhibitor of prostaglandin endoperoxide H synthases 1 and 2.
P2860
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P2860
The productive conformation of arachidonic acid bound to prostaglandin synthase
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2000 nî lūn-bûn
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2000 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի սեպտեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
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2000年论文
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name
The productive conformation of arachidonic acid bound to prostaglandin synthase
@ast
The productive conformation of arachidonic acid bound to prostaglandin synthase
@en
The productive conformation of arachidonic acid bound to prostaglandin synthase
@nl
type
label
The productive conformation of arachidonic acid bound to prostaglandin synthase
@ast
The productive conformation of arachidonic acid bound to prostaglandin synthase
@en
The productive conformation of arachidonic acid bound to prostaglandin synthase
@nl
prefLabel
The productive conformation of arachidonic acid bound to prostaglandin synthase
@ast
The productive conformation of arachidonic acid bound to prostaglandin synthase
@en
The productive conformation of arachidonic acid bound to prostaglandin synthase
@nl
P2093
P1433
P1476
The productive conformation of arachidonic acid bound to prostaglandin synthase
@en
P2093
M G Malkowski
R M Garavito
S L Ginell
P304
P356
10.1126/SCIENCE.289.5486.1933
P407
P577
2000-09-15T00:00:00Z