Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis
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Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolatesAICA-ribosiduria: a novel, neurologically devastating inborn error of purine biosynthesis caused by mutation of ATICNew class of IMP cyclohydrolases in Methanococcus jannaschii.Crystal Structure of a Putative Methyltransferase from Mycobacterium tuberculosis: Misannotation of a Genome Clarified by Protein Structural AnalysisThe crystal structure of the hydrolase domain of 10-formyltetrahydrofolate dehydrogenase: mechanism of hydrolysis and its interplay with the dehydrogenase domainStructure-based design, synthesis, evaluation, and crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolaseA Novel Function for the N-Terminal Nucleophile Hydrolase Fold Demonstrated by the Structure of an Archaeal Inosine Monophosphate Cyclohydrolase † , ‡Crystal Structure and Function of 5-Formaminoimidazole-4-carboxamide Ribonucleotide Synthetase from Methanocaldococcus jannaschii † , ‡Structural Analyses of a Purine Biosynthetic Enzyme from Mycobacterium tuberculosis Reveal a Novel Bound NucleotideBiological and Structural Evaluation of 10 R - and 10 S -Methylthio-DDACTHF Reveals a New Role for Sulfur in Inhibition of Glycinamide Ribonucleotide TransformylaseThe kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase). A surprising lack of substrate channelingThe last enzyme of the de novo purine synthesis pathway 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) plays a central role in insulin signaling and the Golgi/endosomes protein networkCrystal structure of avian aminoimidazole-4-carboxamide ribonucleotide transformylase in complex with a novel non-folate inhibitor identified by virtual ligand screening.Evolution of the deaminase fold and multiple origins of eukaryotic editing and mutagenic nucleic acid deaminases from bacterial toxin systems.Genetic requirements for potassium ion-dependent colony spreading in Bacillus subtilis.Targeting tumour proliferation with a small-molecule inhibitor of AICAR transformylase homodimerizationExploring key orientations at protein-protein interfaces with small molecule probes.Plasticity in the purine-thiamine metabolic network of Salmonella.Structural biology of the purine biosynthetic pathway.Expression, purification, crystallization and preliminary X-ray diffraction crystallographic study of PurH from Escherichia coli.A structural perspective on enzymes activated by monovalent cations.Colocalization and Sequential Enzyme Activity in Aqueous Biphasic Systems: Experiments and Modeling.Role of Na+ and K+ in enzyme function.A marriage of two "Methusalem" drugs for the treatment of psoriasis?: Arguments for a pilot trial with metformin as add-on for methotrexate.The purinosome, a multi-protein complex involved in the de novo biosynthesis of purines in humans.A New View into the Regulation of Purine Metabolism: The Purinosome.Characterization of AICAR transformylase/IMP cyclohydrolase (ATIC) from Staphylococcus lugdunensis.Bifunctional enzyme ATIC promotes propagation of hepatocellular carcinoma by regulating AMPK-mTOR-S6 K1 signaling.Characterization of a novel AICARFT inhibitor which potently elevates ZMP and has anti-tumor activity in murine models
P2860
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P2860
Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis
description
2001 nî lūn-bûn
@nan
2001 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Crystal structure of a bifunct ...... enzyme in purine biosynthesis
@ast
Crystal structure of a bifunct ...... enzyme in purine biosynthesis
@en
Crystal structure of a bifunct ...... enzyme in purine biosynthesis
@nl
type
label
Crystal structure of a bifunct ...... enzyme in purine biosynthesis
@ast
Crystal structure of a bifunct ...... enzyme in purine biosynthesis
@en
Crystal structure of a bifunct ...... enzyme in purine biosynthesis
@nl
prefLabel
Crystal structure of a bifunct ...... enzyme in purine biosynthesis
@ast
Crystal structure of a bifunct ...... enzyme in purine biosynthesis
@en
Crystal structure of a bifunct ...... enzyme in purine biosynthesis
@nl
P2093
P356
P1476
Crystal structure of a bifunct ...... enzyme in purine biosynthesis
@en
P2093
G P Beardsley
I A Wilson
J Ramcharan
S E Greasley
S J Benkovic
P2888
P356
10.1038/87555
P577
2001-05-01T00:00:00Z
P5875
P6179
1024678794