Mechanism of insulin chain combination. Asymmetric roles of A-chain alpha-helices in disulfide pairing
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Design of an Active Ultrastable Single-chain Insulin Analog: SYNTHESIS, STRUCTURE, AND THERAPEUTIC IMPLICATIONSEnhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINSCrystal Structure of a"Nonfoldable"Insulin: IMPAIRED FOLDING EFFICIENCY DESPITE NATIVE ACTIVITYFully Convergent Chemical Synthesis of Ester Insulin: Determination of the High Resolution X-ray Structure by Racemic Protein CrystallographyConformational dynamics of insulin.Chiral mutagenesis of insulin. Foldability and function are inversely regulated by a stereospecific switch in the B chainProinsulin is refractory to protein fibrillation: topological protection of a precursor protein from cross-beta assembly.Contribution of residue B5 to the folding and function of insulin and IGF-I: constraints and fine-tuning in the evolution of a protein family.Deciphering the hidden informational content of protein sequences: foldability of proinsulin hinges on a flexible arm that is dispensable in the mature hormoneProinsulin misfolding and diabetes: mutant INS gene-induced diabetes of youth.Proinsulin and the genetics of diabetes mellitusThe structure and function of insulin: decoding the TR transitionThe structure of a mutant insulin uncouples receptor binding from protein allostery. An electrostatic block to the TR transition.Proinsulin disulfide maturation and misfolding in the endoplasmic reticulumInsulin: a model system for nanomedicine?Diabetes mellitus due to the toxic misfolding of proinsulin variants.Insulin: a small protein with a long journey.Nisin-inducible secretion of a biologically active single-chain insulin analog by Lactococcus lactis NZ9000.A conserved histidine in insulin is required for the foldability of human proinsulin: structure and function of an ALAB5 analog.Role of the connecting peptide in insulin biosynthesis.Design and folding of [GluA4(ObetaThrB30)]insulin ("ester insulin"): a minimal proinsulin surrogate that can be chemically converted into human insulinBiomimetic synthesis of lispro insulin via a chemically synthesized "mini-proinsulin" prepared by oxime-forming ligation.In vitro refolding of human proinsulin. Kinetic intermediates, putative disulfide-forming pathway folding initiation site, and potential role of C-peptide in folding process.Transdermal Protein Delivery Using Choline and Geranate (CAGE) Deep Eutectic Solvent.Insulin in motion: The A6-A11 disulfide bond allosterically modulates structural transitions required for insulin activity.Unfolding of human proinsulin. Intermediates and possible role of its C-peptide in folding/unfolding.
P2860
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P2860
Mechanism of insulin chain combination. Asymmetric roles of A-chain alpha-helices in disulfide pairing
description
2002 nî lūn-bûn
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2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
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2002 թվականի նոյեմբերին հրատարակված գիտական հոդված
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2002年の論文
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年學術文章
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name
Mechanism of insulin chain com ...... a-helices in disulfide pairing
@ast
Mechanism of insulin chain com ...... a-helices in disulfide pairing
@en
Mechanism of insulin chain com ...... a-helices in disulfide pairing
@nl
type
label
Mechanism of insulin chain com ...... a-helices in disulfide pairing
@ast
Mechanism of insulin chain com ...... a-helices in disulfide pairing
@en
Mechanism of insulin chain com ...... a-helices in disulfide pairing
@nl
prefLabel
Mechanism of insulin chain com ...... a-helices in disulfide pairing
@ast
Mechanism of insulin chain com ...... a-helices in disulfide pairing
@en
Mechanism of insulin chain com ...... a-helices in disulfide pairing
@nl
P2093
P2860
P356
P1476
Mechanism of insulin chain com ...... a-helices in disulfide pairing
@en
P2093
Michael A Weiss
Nelson F B Phillips
Panayotis G Katsoyannis
Qing-Xin Hua
Run-Ying Wang
Wenhua Jia
Ying-Chi Chu
P2860
P304
P356
10.1074/JBC.M206107200
P407
P577
2002-11-08T00:00:00Z