Structural Definition of an Antibody-Dependent Cellular Cytotoxicity Response Implicated in Reduced Risk for HIV-1 Infection - Test2 - elhamkhani - TriplyDB

Structural Definition of an Antibody-Dependent Cellular Cytotoxicity Response Implicated in Reduced Risk for HIV-1 Infection

Structural Definition of an Antibody-Dependent Cellular Cytotoxicity Response Implicated in Reduced Risk for HIV-1 Infection

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Harnessing the protective potential of HIV-1 neutralizing antibodies Conformational Masking and Receptor-Dependent Unmasking of Highly Conserved Env Epitopes Recognized by Non-Neutralizing Antibodies That Mediate Potent ADCC against HIV-1 Human Non-neutralizing HIV-1 Envelope Monoclonal Antibodies Limit the Number of Founder Viruses during SHIV Mucosal Infection in Rhesus Macaques HIV-1 gp120 as a therapeutic target: navigating a moving labyrinth Survivors Remorse: antibody-mediated protection against HIV-1.Dimeric FcγR Ectodomains as Probes of the Fc Receptor Function of Anti-Influenza Virus IgG.Humoral and Innate Antiviral Immunity as Tools to Clear Persistent HIV Infection Probing the Impact of Local Structural Dynamics of Conformational Epitopes on Antibody Recognition.The HIV-1 gp120 CD4-bound conformation is preferentially targeted by antibody-dependent cellular cytotoxicity-mediating antibodies in sera from HIV-1-infected individuals Conserved molecular signatures in gp120 are associated with the genetic bottleneck during simian immunodeficiency virus (SIV), SIV-human immunodeficiency virus (SHIV), and HIV type 1 (HIV-1) transmission Effects of the I559P gp41 change on the conformation and function of the human immunodeficiency virus (HIV-1) membrane envelope glycoprotein trimer.What Do Chaotrope-Based Avidity Assays for Antibodies to HIV-1 Envelope Glycoproteins Measure?CD4 mimetics sensitize HIV-1-infected cells to ADCC.The function and affinity maturation of HIV-1 gp120-specific monoclonal antibodies derived from colostral B cells Targeting HIV Reservoir in Infected CD4 T Cells by Dual-Affinity Re-targeting Molecules (DARTs) that Bind HIV Envelope and Recruit Cytotoxic T Cells.Cocrystal Structures of Antibody N60-i3 and Antibody JR4 in Complex with gp120 Define More Cluster A Epitopes Involved in Effective Antibody-Dependent Effector Function against HIV-1 HIV-specific CD4-induced Antibodies Mediate Broad and Potent Antibody-dependent Cellular Cytotoxicity Activity and Are Commonly Detected in Plasma From HIV-infected humans Dual-Affinity Re-Targeting proteins direct T cell-mediated cytolysis of latently HIV-infected cells.Chemical Cross-Linking Stabilizes Native-Like HIV-1 Envelope Glycoprotein Trimer Antigens Range of CD4-Bound Conformations of HIV-1 gp120, as Defined Using Conditional CD4-Induced Antibodies.A new cell line for high throughput HIV-specific antibody-dependent cellular cytotoxicity (ADCC) and cell-to-cell virus transmission studies.The role of Fc receptors in HIV prevention and therapy.Co-receptor Binding Site Antibodies Enable CD4-Mimetics to Expose Conserved Anti-cluster A ADCC Epitopes on HIV-1 Envelope Glycoproteins.Molecular basis for epitope recognition by non-neutralizing anti-gp41 antibody F240 Fc Receptor-Mediated Activities of Env-Specific Human Monoclonal Antibodies Generated from Volunteers Receiving the DNA Prime-Protein Boost HIV Vaccine DP6-001 HIV-1 Consensus Envelope-Induced Broadly Binding Antibodies.Envelope-specific antibodies and antibody-derived molecules for treating and curing HIV infection HIV antibodies for treatment of HIV infection.Antibody Functional Assays as Measures of Fc Receptor-Mediated Immunity to HIV - New Technologies and their Impact on the HIV Vaccine Field.Vorinostat Renders the Replication-Competent Latent Reservoir of Human Immunodeficiency Virus (HIV) Vulnerable to Clearance by CD8 T Cells.Quaternary contact in the initial interaction of CD4 with the HIV-1 envelope trimer.Beyond Viral Neutralization.A Highly Conserved gp120 Inner Domain Residue Modulates Env Conformation and Trimer Stability.Paring Down HIV Env: Design and Crystal Structure of a Stabilized Inner Domain of HIV-1 gp120 Displaying a Major ADCC Target of the A32 Region.An HIV gp120-CD4 Immunogen Does Not Elicit Autoimmune Antibody Responses in Cynomolgus Macaques A Highly Conserved Residue of the HIV-1 gp120 Inner Domain Is Important for Antibody-Dependent Cellular Cytotoxicity Responses Mediated by Anti-cluster A Antibodies Crystal structures of human Fabs targeting the Bexsero meningococcal vaccine antigen NHBA Patterns of conserved gp120 epitope presentation on attached HIV-1 virions.Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations.Targeting the Late Stage of HIV-1 Entry for Antibody-Dependent Cellular Cytotoxicity: Structural Basis for Env Epitopes in the C11 Region.

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Structural Definition of an Antibody-Dependent Cellular Cytotoxicity Response Implicated in Reduced Risk for HIV-1 Infection

http://www.wikidata.org/entity/Q27640572

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2014 nî lūn-bûn

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2014 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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Structural Definition of an An ...... duced Risk for HIV-1 Infection

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Journal of Virology

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Anthony L DeVico

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Baoshan Zhang

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Chih-Chin Huang

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George K Lewis

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James E Robinson

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James S Foulke

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Lei Yu

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Loïc Martin

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Marie Pancera

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Marzena Pazgier

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P2860

Structural mechanism of trimeric HIV-1 envelope glycoprotein activation

HIV-specific antibodies capable of ADCC are common in breastmilk and are associated with reduced risk of transmission in women with high viral loads

MolProbity: all-atom structure validation for macromolecular crystallography

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

ADCC develops over time during persistent infection with live-attenuated SIV and is associated with complete protection against SIV(mac)251 challenge

Molecular architecture of native HIV-1 gp120 trimers

Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility

Diverse specificity and effector function among human antibodies to HIV-1 envelope glycoprotein epitopes exposed by CD4 binding

Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops

Structural Basis for Highly Effective HIV-1 Neutralization by CD4-Mimetic Miniproteins Revealed by 1.5 Å Cocrystal Structure of gp120 and M48U1

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12895-12906

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2617655

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10.1128/JVI.02194-14

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21

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88

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William D Tolbert

Neelakshi Gohain

Jason S McLellan

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2014-08-27T00:00:00Z

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265134132

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25165110

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4248932

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