Novel uncomplexed and complexed structures of plasmepsin II, an aspartic protease from Plasmodium falciparum
about
Potencies of human immunodeficiency virus protease inhibitors in vitro against Plasmodium falciparum and in vivo against murine malariaTransition-state inhibitors of purine salvage and other prospective enzyme targets in malariaRecombinant Plasmepsin 1 from the Human Malaria Parasite Plasmodium falciparum : Enzymatic Characterization, Active Site Inhibitor Design, and Structural AnalysisCrystal Structures of the Histo-Aspartic Protease (HAP) from Plasmodium falciparumCrystal structures of the free and inhibited forms of plasmepsin I (PMI) from Plasmodium falciparumStructural Insights into the Activation and Inhibition of Histo-Aspartic Protease from Plasmodium falciparumPlasmepsin Inhibitory Activity and Structure-Guided Optimization of a Potent Hydroxyethylamine-Based Antimalarial HitThe Potential of Secondary Metabolites from Plants as Drugs or Leads against Protozoan Neglected Diseases-Part III: In-Silico Molecular Docking InvestigationsDiscovery of plasmepsin inhibitors by fragment-based docking and consensus scoringIdentification of proteins targeted by the thioredoxin superfamily in Plasmodium falciparumHydroxyethylamine Based Phthalimides as New Class of Plasmepsin Hits: Design, Synthesis and Antimalarial EvaluationEnzymatic Characterization of Recombinant Food Vacuole Plasmepsin 4 from the Rodent Malaria Parasite Plasmodium bergheiFlap dynamics of plasmepsin proteases: insight into proposed parameters and molecular dynamicsGrassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation.Computational analysis of plasmepsin IV bound to an allophenylnorstatine inhibitor.Identification of Tight-Binding Plasmepsin II and Falcipain 2 Inhibitors in Aqueous Extracts of Marine Invertebrates by the Combination of Enzymatic and Interaction-Based Assays.Computational perspectives into plasmepsins structure-function relationship: implications to inhibitors design.Structural studies of vacuolar plasmepsinsProtein functional surfaces: global shape matching and local spatial alignments of ligand binding sites.Understanding the structural basis of substrate recognition by Plasmodium falciparum plasmepsin V to aid in the design of potent inhibitors.Plasmodium falciparum: new molecular targets with potential for antimalarial drug development.Flap flexibility amongst plasmepsins I, II, III, IV, and V: Sequence, structural, and molecular dynamics analyses.Structures of plasmepsin II from Plasmodium falciparum in complex with two hydroxyethylamine-based inhibitors.Analysis of binding interactions of pepsin inhibitor-3 to mammalian and malarial aspartic proteases.Plasmepsin inhibitors: design, synthesis, inhibitory studies and crystal structure analysis.Genetic disruption of the Plasmodium falciparum digestive vacuole plasmepsins demonstrates their functional redundancy.Distal substrate interactions enhance plasmepsin activity.X-ray structure of plasmepsin II complexed with a potent achiral inhibitor.Insight into selectivity of peptidomimetic inhibitors with modified statine core for plasmepsin II of Plasmodium falciparum over human cathepsin D.Replacement of isobutyl by trifluoromethyl in pepstatin A selectively affects inhibition of aspartic proteinases.Computational analysis of aspartic protease plasmepsin II complexed with EH58 inhibitor: a QM/MM MD study.Crystal structure of Plasmodium falciparum proplasmepsin IV: the plasticity of proplasmepsins.Sequence, Structural Analysis and Metrics to Define the Unique Dynamic Features of the Flap Regions Among Aspartic Proteases.Modeling and resistant alleles explain the selectivity of antimalarial compound 49c towards apicomplexan aspartyl proteases.
P2860
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P2860
Novel uncomplexed and complexed structures of plasmepsin II, an aspartic protease from Plasmodium falciparum
description
2003 nî lūn-bûn
@nan
2003 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մարտին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Novel uncomplexed and complexe ...... ase from Plasmodium falciparum
@ast
Novel uncomplexed and complexe ...... ase from Plasmodium falciparum
@en
Novel uncomplexed and complexe ...... ase from Plasmodium falciparum
@nl
type
label
Novel uncomplexed and complexe ...... ase from Plasmodium falciparum
@ast
Novel uncomplexed and complexe ...... ase from Plasmodium falciparum
@en
Novel uncomplexed and complexe ...... ase from Plasmodium falciparum
@nl
prefLabel
Novel uncomplexed and complexe ...... ase from Plasmodium falciparum
@ast
Novel uncomplexed and complexe ...... ase from Plasmodium falciparum
@en
Novel uncomplexed and complexe ...... ase from Plasmodium falciparum
@nl
P2093
P3181
P1476
Novel uncomplexed and complexe ...... ase from Plasmodium falciparum
@en
P2093
Abelardo M Silva
Elena Afonina
Jonathan A Ellman
Sergei V Gulnik
Tasir S Haque
P304
P3181
P356
10.1016/S0022-2836(03)00036-6
P407
P577
2003-03-14T00:00:00Z