Structural basis for the antibiotic activity of ketolides and azalides
about
Binding and action of CEM-101, a new fluoroketolide antibiotic that inhibits protein synthesisAlterations at the peptidyl transferase centre of the ribosome induced by the synergistic action of the streptogramins dalfopristin and quinupristinLocalization of spermine binding sites in 23S rRNA by photoaffinity labeling: parsing the spermine contribution to ribosomal 50S subunit functionsPOPSCOMP: an automated interaction analysis of biomolecular complexes.Ribosomal Antibiotics: Contemporary ChallengesAntibiotics that target protein synthesisL11 domain rearrangement upon binding to RNA and thiostrepton studied by NMR spectroscopyStructural Insight into the Antibiotic Action of Telithromycin against Resistant MutantsThe Structures of Antibiotics Bound to the E Site Region of the 50 S Ribosomal Subunit of Haloarcula marismortui: 13-Deoxytedanolide and GirodazoleMolecular Architecture of DesI: A Key Enzyme in the Biosynthesis of Desosamine † , ‡Structures of Triacetyloleandomycin and Mycalamide A Bind to the Large Ribosomal Subunit of Haloarcula marismortuiThe structure of ribosome-lankacidin complex reveals ribosomal sites for synergistic antibioticsRevisiting the structures of several antibiotics bound to the bacterial ribosomeFrom Erythromycin to Azithromycin and New Potential Ribosome-Binding Antimicrobials.Targeting Antibiotic ResistanceThe bacterial ribosome as a target for antibioticsReduced ribosomes of the apicoplast and mitochondrion of Plasmodium spp. and predicted interactions with antibioticsNewer antibacterial drugs for a new century.The structural basis for substrate anchoring, active site selectivity, and product formation by P450 PikC from Streptomyces venezuelae.Characterization of GE82832, a peptide inhibitor of translocation interacting with bacterial 30S ribosomal subunitsKinetics of macrolide action: the josamycin and erythromycin cases.Recombineering reveals a diverse collection of ribosomal proteins L4 and L22 that confer resistance to macrolide antibiotics.23S rRNA base pair 2057-2611 determines ketolide susceptibility and fitness cost of the macrolide resistance mutation 2058A-->G.Ketolides: an emerging treatment for macrolide-resistant respiratory infections, focusing on S. pneumoniae.Photolabile anticodon stem-loop analogs of tRNAPhe as probes of ribosomal structure and structural fluctuation at the decoding center.Chemistry and biology of macrolide antiparasitic agents.Negamycin interferes with decoding and translocation by simultaneous interaction with rRNA and tRNA23S rRNA 2058A-->G alteration mediates ketolide resistance in combination with deletion in L22.Azithromycin plus chloroquine: combination therapy for protection against malaria and sexually transmitted infections in pregnancy.Structural insight into functional aspects of ribosomal RNA targeting.Ribosomal tolerance and peptide bond formation.Ribosomal crystallography: a flexible nucleotide anchoring tRNA translocation, facilitates peptide-bond formation, chirality discrimination and antibiotics synergism.From peptide-bond formation to cotranslational folding: dynamic, regulatory and evolutionary aspects.Precursor directed biosynthesis of an orthogonally functional erythromycin analogue: selectivity in the ribosome macrolide binding pocketAntimicrobial susceptibility testing, drug resistance mechanisms, and therapy of infections with nontuberculous mycobacteria.Capreomycin susceptibility is increased by TlyA-directed 2'-O-methylation on both ribosomal subunits.Tailoring pathway modularity in the biosynthesis of erythromycin analogs heterologously engineered in E. coliThe ribosomal peptidyl transferase center: structure, function, evolution, inhibition.Species-specific antibiotic-ribosome interactions: implications for drug development.Antibiotics and the ribosome.
P2860
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P2860
Structural basis for the antibiotic activity of ketolides and azalides
description
2003 nî lūn-bûn
@nan
2003 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մարտին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Structural basis for the antibiotic activity of ketolides and azalides
@ast
Structural basis for the antibiotic activity of ketolides and azalides
@en
Structural basis for the antibiotic activity of ketolides and azalides
@nl
type
label
Structural basis for the antibiotic activity of ketolides and azalides
@ast
Structural basis for the antibiotic activity of ketolides and azalides
@en
Structural basis for the antibiotic activity of ketolides and azalides
@nl
prefLabel
Structural basis for the antibiotic activity of ketolides and azalides
@ast
Structural basis for the antibiotic activity of ketolides and azalides
@en
Structural basis for the antibiotic activity of ketolides and azalides
@nl
P2093
P50
P3181
P1433
P1476
Structural basis for the antibiotic activity of ketolides and azalides
@en
P2093
Francois Franceschi
Frank Schlünzen
Harly A S Hansen
Jörg M Harms
P304
P3181
P356
10.1016/S0969-2126(03)00022-4
P577
2003-03-01T00:00:00Z