Structural insight into the role of the ribosomal tunnel in cellular regulation
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Codon usage: nature's roadmap to expression and folding of proteinsRibosomal Antibiotics: Contemporary ChallengesMultipotent mesenchymal stromal cells: A promising strategy to manage alcoholic liver diseaseAntibiotics that target protein synthesisStructural Insight into the Antibiotic Action of Telithromycin against Resistant MutantsStructures of Triacetyloleandomycin and Mycalamide A Bind to the Large Ribosomal Subunit of Haloarcula marismortuiThe structure of ribosome-lankacidin complex reveals ribosomal sites for synergistic antibioticsThe bacterial ribosome as a target for antibioticsHeterologous protein expression is enhanced by harmonizing the codon usage frequencies of the target gene with those of the expression host.Sequence coevolution between RNA and protein characterized by mutual information between residue tripletsAntibiotics: where to throw the spanner in the ribosomal machinery?Side-chain recognition and gating in the ribosome exit tunnel.The structural basis for substrate anchoring, active site selectivity, and product formation by P450 PikC from Streptomyces venezuelae.Kinetics of macrolide action: the josamycin and erythromycin cases.Intrinsic and selected resistance to antibiotics binding the ribosome: analyses of Brucella 23S rrn, L4, L22, EF-Tu1, EF-Tu2, efflux and phylogenetic implicationsGenetic identification of nascent peptides that induce ribosome stalling.Molecular mechanisms by which rRNA mutations confer resistance to clindamycinLarge facilities and the evolving ribosome, the cellular machine for genetic-code translationSite-specific release of nascent chains from ribosomes at a sense codon.Chemistry and biology of macrolide antiparasitic agents.Induction of efflux-mediated macrolide resistance in Streptococcus pneumoniae23S rRNA 2058A-->G alteration mediates ketolide resistance in combination with deletion in L22.Polytopic membrane protein folding at L17 in the ribosome tunnel initiates cyclical changes at the transloconTransmembrane segments of nascent polytopic membrane proteins control cytosol/ER targeting during membrane integrationStructural insight into functional aspects of ribosomal RNA targeting.Ribosomal tolerance and peptide bond formation.Intraribosomal regulation of expression and fate of proteins.Recognition of the regulatory nascent chain TnaC by the ribosomeThe co-translational folding and interactions of nascent protein chains: a new approach using fluorescence resonance energy transfer.From peptide-bond formation to cotranslational folding: dynamic, regulatory and evolutionary aspects.Ribosomal proteins in the spotlight.Antibiotics and the ribosome.Arginine changes the conformation of the arginine attenuator peptide relative to the ribosome tunnelWidespread regulation of translation by elongation pausing in heat shockStructural basis for cross-resistance to ribosomal PTC antibiotics.Tertiary interactions within the ribosomal exit tunnel.Regional discrimination and propagation of local rearrangements along the ribosomal exit tunnel.The plasticity of a translation arrest motif yields insights into nascent polypeptide recognition inside the ribosome tunnelIdentification of novel macrolides with antibacterial, anti-inflammatory and type I and III IFN-augmenting activity in airway epithelium.A nascent polypeptide domain that can regulate translation elongation.
P2860
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P2860
Structural insight into the role of the ribosomal tunnel in cellular regulation
description
2003 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մայիսին հրատարակված գիտական հոդված
@hy
article scientifique (publié 2003-05)
@fr
articolo scientifico (pubblicato il 2003-05)
@it
artigo científico (publicado na 2003-05)
@pt
artículu científicu espublizáu en 2003
@ast
scientific article (publication date: May 2003)
@en
vedecký článok (publikovaný 2003-05)
@sk
vetenskaplig artikel (publicerad på 2003-05)
@sv
videnskabelig artikel (udgivet 2003-05)
@da
name
Structural insight into the role of the ribosomal tunnel in cellular regulation
@ast
Structural insight into the role of the ribosomal tunnel in cellular regulation
@en
Structural insight into the role of the ribosomal tunnel in cellular regulation
@nl
type
label
Structural insight into the role of the ribosomal tunnel in cellular regulation
@ast
Structural insight into the role of the ribosomal tunnel in cellular regulation
@en
Structural insight into the role of the ribosomal tunnel in cellular regulation
@nl
prefLabel
Structural insight into the role of the ribosomal tunnel in cellular regulation
@ast
Structural insight into the role of the ribosomal tunnel in cellular regulation
@en
Structural insight into the role of the ribosomal tunnel in cellular regulation
@nl
P50
P3181
P356
P1476
Structural insight into the role of the ribosomal tunnel in cellular regulation
@en
P304
P3181
P356
10.1038/NSB915
P577
2003-05-01T00:00:00Z