Insights into antifolate resistance from malarial DHFR-TS structures
about
Novel triazine JPC-2067-B inhibits Toxoplasma gondii in vitro and in vivoThat Was Then But This Is Now: Malaria Research in the Time of an Eradication AgendaHomology building as a means to define antigenic epitopes on dihydrofolate reductase (DHFR) from Plasmodium falciparumTransition-state inhibitors of purine salvage and other prospective enzyme targets in malariaArtemisinins: their growing importance in medicinePhylogenetic classification of protozoa based on the structure of the linker domain in the bifunctional enzyme, dihydrofolate reductase-thymidylate synthaseSynthetic and Crystallographic Studies of a New Inhibitor Series Targeting Bacillus anthracis Dihydrofolate ReductaseExploiting Structural Analysis, in Silico Screening, and Serendipity To Identify Novel Inhibitors of Drug-Resistant Falciparum MalariaX-ray structure of the ternary MTX.NADPH complex of the anthrax dihydrofolate reductase: a pharmacophore for dual-site inhibitor designPreclinical Evaluation of the Antifolate QN254, 5-Chloro- N'6'-(2,5-Dimethoxy-Benzyl)-Quinazoline-2,4,6-Triamine, as an Antimalarial Drug CandidateCrystal Structure of Arginase from Plasmodium falciparum and Implications for l -Arginine Depletion in Malarial Infection,Inhibitor-bound complexes of dihydrofolate reductase-thymidylate synthase from Babesia bovisMalarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised targetCombined Spatial Limitation around Residues 16 and 108 of Plasmodium falciparum Dihydrofolate Reductase Explains Resistance to CycloguanilFirst Three-Dimensional Structure of Toxoplasma gondii Thymidylate Synthase–Dihydrofolate Reductase: Insights for Catalysis, Interdomain Interactions, and Substrate ChannelingExploring novel strategies for AIDS protozoal pathogens: α-helix mimetics targeting a key allosteric protein–protein interaction in C. hominis thymidylate synthase-dihydrofolate reductase (TS-DHFR)Evolution of vitamin B2 biosynthesis: eubacterial RibG and fungal Rib2 deaminasesThe molecular basis of folate salvage in Plasmodium falciparum: characterization of two folate transportersThe Potential of Secondary Metabolites from Plants as Drugs or Leads against Protozoan Neglected Diseases-Part III: In-Silico Molecular Docking InvestigationsTowards genome-wide experimental genetics in the in vivo malaria model parasite Plasmodium bergheiEvolutionary patterning: a novel approach to the identification of potential drug target sites in Plasmodium falciparumResistance of a rodent malaria parasite to a thymidylate synthase inhibitor induces an apoptotic parasite death and imposes a huge cost of fitnessTrypanosoma brucei DHFR-TS Revisited: Characterisation of a Bifunctional and Highly Unstable Recombinant Dihydrofolate Reductase-Thymidylate SynthaseTargeting purine and pyrimidine metabolism in human apicomplexan parasitesOpportunities and Challenges in Antiparasitic Drug DiscoveryBiochemical and functional characterization of Plasmodium falciparum GTP cyclohydrolase IConflicting requirements of Plasmodium falciparum dihydrofolate reductase mutations conferring resistance to pyrimethamine-WR99210 combination.Genotyping of Plasmodium falciparum pyrimethamine resistance by matrix-assisted laser desorption-ionization time-of-flight mass spectrometry.Integration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge space?WISDOM-II: screening against multiple targets implicated in malaria using computational grid infrastructures.Linkage group selection: rapid gene discovery in malaria parasitesAntifolate Agents Against Wild and Mutant Strains of Plasmodium falciparumBEAR, a novel virtual screening methodology for drug discovery.Fragment screening of infectious disease targets in a structural genomics environmentSelection of drug resistant mutants from random library of Plasmodium falciparum dihydrofolate reductase in Plasmodium berghei modelCrystal structure of dihydrofolate reductase from Plasmodium vivax: pyrimethamine displacement linked with mutation-induced resistance.Antifolate agents: a patent review (2006 - 2010).Compensatory mutations restore fitness during the evolution of dihydrofolate reductaseBinding modes of 2,4-diaminoquinazoline and 2,4-diaminopteridine analogs to P. falciparum dihydrofolate reductase enzyme: Molecular docking studies.Quadruple mutations in dihydrofolate reductase of Plasmodium falciparum isolates from Car Nicobar Island, India.
P2860
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P2860
Insights into antifolate resistance from malarial DHFR-TS structures
description
2003 nî lūn-bûn
@nan
2003 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Insights into antifolate resistance from malarial DHFR-TS structures
@ast
Insights into antifolate resistance from malarial DHFR-TS structures
@en
Insights into antifolate resistance from malarial DHFR-TS structures
@nl
type
label
Insights into antifolate resistance from malarial DHFR-TS structures
@ast
Insights into antifolate resistance from malarial DHFR-TS structures
@en
Insights into antifolate resistance from malarial DHFR-TS structures
@nl
prefLabel
Insights into antifolate resistance from malarial DHFR-TS structures
@ast
Insights into antifolate resistance from malarial DHFR-TS structures
@en
Insights into antifolate resistance from malarial DHFR-TS structures
@nl
P2093
P50
P921
P3181
P356
P1476
Insights into antifolate resistance from malarial DHFR-TS structures
@en
P2093
Jarunee Vanichtanankul
Paul Taylor
Penchit Chitnumsub
Worachart Sirawaraporn
P304
P3181
P356
10.1038/NSB921
P577
2003-05-01T00:00:00Z