NO and CO differentially activate soluble guanylyl cyclase via a heme pivot-bend mechanism.
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The RCK1 high-affinity Ca2+ sensor confers carbon monoxide sensitivity to Slo1 BK channelsPAS-mediated Dimerization of Soluble Guanylyl Cyclase Revealed by Signal Transduction Histidine Kinase Domain Crystal StructureThe crystal structure of the catalytic domain of a eukaryotic guanylate cyclaseProbing the Function of Heme Distortion in the H-NOX FamilyA structural basis for H-NOX signaling in Shewanella oneidensis by trapping a histidine kinase inhibitory conformationCrystal structure of the signaling helix coiled-coil domain of the β1 subunit of the soluble guanylyl cyclaseStructural insights into the molecular mechanism of H-NOX activationStructure of cinaciguat (BAY 58-2667) bound to Nostoc H-NOX domain reveals insights into heme-mimetic activation of the soluble guanylyl cyclase.Interaction of nitric oxide with catalase: structural and kinetic analysis.Controlling Conformational Flexibility of an O 2 -Binding H-NOX DomainTunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domainInsights into BAY 60-2770 Activation and S -Nitrosylation-Dependent Desensitization of Soluble Guanylyl Cyclase via Crystal Structures of Homologous Nostoc H-NOX Domain ComplexesCrystal structure of the Alpha subunit PAS domain from soluble guanylyl cyclaseInterfacial residues promote an optimal alignment of the catalytic center in human soluble guanylate cyclase: heterodimerization is required but not sufficient for activity.Identification of residues in the heme domain of soluble guanylyl cyclase that are important for basal and stimulated catalytic activityFluorescence dequenching makes haem-free soluble guanylate cyclase detectable in living cellsHigher-order interactions bridge the nitric oxide receptor and catalytic domains of soluble guanylate cyclase.Fluorescent fusion proteins of soluble guanylyl cyclase indicate proximity of the heme nitric oxide domain and catalytic domain.Carbon monoxide--physiology, detection and controlled release.Nitric oxide blocks cellular heme insertion into a broad range of heme proteinsIs Nostoc H-NOX a NO sensor or redox switch?The fibrate gemfibrozil is a NO- and haem-independent activator of soluble guanylyl cyclase: in vitro studies.How do heme-protein sensors exclude oxygen? Lessons learned from cytochrome c', Nostoc puntiforme heme nitric oxide/oxygen-binding domain, and soluble guanylyl cyclase.Probing vibrational anisotropy with nuclear resonance vibrational spectroscopy.Structural insights into the role of iron-histidine bond cleavage in nitric oxide-induced activation of H-NOX gas sensor proteins.Oxygen mediates vascular smooth muscle relaxation in hypoxiaDesigned iron carbonyls as carbon monoxide (CO) releasing molecules: rapid CO release and delivery to myoglobin in aqueous buffer, and vasorelaxation of mouse aortaComprehensive Fe-ligand vibration identification in {FeNO}6 hemes.Oxidation and loss of heme in soluble guanylyl cyclase from Manduca sexta.Probing the local electronic and geometric properties of the heme iron center in a H-NOX domainGas what: NO is not the only answer to sexual function.Motion of proximal histidine and structural allosteric transition in soluble guanylate cyclase.Dynamic ligand exchange in soluble guanylyl cyclase (sGC): implications for sGC regulation and desensitization.Aspartate 102 in the heme domain of soluble guanylyl cyclase has a key role in NO activation.Desensitization of soluble guanylyl cyclase, the NO receptor, by S-nitrosylationHeat Shock Protein 90 Associates with the Per-Arnt-Sim Domain of Heme-free Soluble Guanylate Cyclase: IMplications for Enzyme Maturation.Heme-assisted S-nitrosation desensitizes ferric soluble guanylate cyclase to nitric oxidePrimary response of the sGC heme binding domain to the cleavage of the Fe-His bond.Molecular model of a soluble guanylyl cyclase fragment determined by small-angle X-ray scattering and chemical cross-linking.Reversible NO motion in crystalline [Fe(Porph)(1-MeIm)(NO)] derivatives
P2860
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P2860
NO and CO differentially activate soluble guanylyl cyclase via a heme pivot-bend mechanism.
description
2007 nî lūn-bûn
@nan
2007 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
NO and CO differentially activ ...... ia a heme pivot-bend mechanism
@nl
NO and CO differentially activ ...... a a heme pivot-bend mechanism.
@ast
NO and CO differentially activ ...... a a heme pivot-bend mechanism.
@en
type
label
NO and CO differentially activ ...... ia a heme pivot-bend mechanism
@nl
NO and CO differentially activ ...... a a heme pivot-bend mechanism.
@ast
NO and CO differentially activ ...... a a heme pivot-bend mechanism.
@en
prefLabel
NO and CO differentially activ ...... ia a heme pivot-bend mechanism
@nl
NO and CO differentially activ ...... a a heme pivot-bend mechanism.
@ast
NO and CO differentially activ ...... a a heme pivot-bend mechanism.
@en
P2093
P2860
P356
P1433
P1476
NO and CO differentially activ ...... a a heme pivot-bend mechanism.
@en
P2093
Annie Beuve
Focco van den Akker
Nazish Sayed
Xiaolei Ma
P2860
P304
P356
10.1038/SJ.EMBOJ.7601521
P407
P577
2007-01-11T00:00:00Z