Molecular basis of phosphorylation-induced activation of the NADPH oxidase
about
A systematic comparative and structural analysis of protein phosphorylation sites based on the mtcPTM databasep40phox as an alternative organizer to p47phox in Nox2 activation: a new mechanism involving an interaction with p22phoxNMR solution structure of the tandem Src homology 3 domains of p47phox complexed with a p22phox-derived proline-rich peptideActivation of the superoxide-producing phagocyte NADPH oxidase requires co-operation between the tandem SH3 domains of p47phox in recognition of a polyproline type II helix and an adjacent alpha-helix of p22phoxNovel Src homology 3 domain-binding motifs identified from proteomic screen of a Pro-rich regionStructure of the Eps15-stonin2 complex provides a molecular explanation for EH-domain ligand specificityA fluorescently tagged C-terminal fragment of p47phox detects NADPH oxidase dynamics during phagocytosis.Phosphorylation of Noxo1 at threonine 341 regulates its interaction with Noxa1 and the superoxide-producing activity of Nox1Effects of p47phox C terminus phosphorylations on binding interactions with p40phox and p67phox. Structural and functional comparison of p40phox and p67phox SH3 domainsRegulation of Bin1 SH3 domain binding by phosphoinositidesNADPH oxidases as electrochemical generators to produce ion fluxes and turgor in fungi, plants and humansBiochemistry, physiology, and pathophysiology of NADPH oxidases in the cardiovascular systemNADPH oxidases in heart failure: poachers or gamekeepers?The NADPH oxidase complexes in Botrytis cinerea: evidence for a close association with the ER and the tetraspanin Pls1High-resolution crystal structure of spectrin SH3 domain fused with a proline-rich peptideDeletion mutagenesis of p22phox subunit of flavocytochrome b558: identification of regions critical for gp91phox maturation and NADPH oxidase activityAnalysis of human phagocyte flavocytochrome b(558) by mass spectrometryStructure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen speciesActivation and assembly of the NADPH oxidase: a structural perspectiveNADPH oxidase activation is required in reactive oxygen species generation and cell transformation induced by hexavalent chromiumTks5-dependent, nox-mediated generation of reactive oxygen species is necessary for invadopodia formationExhaustive search of linear information encoding protein-peptide recognitionMolecular basis of interactions between SH3 domain-containing proteins and the proline-rich region of the ubiquitin ligase ItchThe SH3 domain of UNC-89 (obscurin) interacts with paramyosin, a coiled-coil protein, in Caenorhabditis elegans muscle.Preferred SH3 domain partners of ADAM metalloproteases include shared and ADAM-specific SH3 interactions.Molecular insights of p47phox phosphorylation dynamics in the regulation of NADPH oxidase activation and superoxide production.Expression, purification and preliminary crystallographic studies of the C-terminal SH3 domain of human Tks4.Identification of a region in p47phox/NCF1 crucial for phagocytic NADPH oxidase (NOX2) activation.Trimer hydroxylated quinone derived from apocynin targets cysteine residues of p47phox preventing the activation of human vascular NADPH oxidaseSpecificity and versatility of SH3 and other proline-recognition domains: structural basis and implications for cellular signal transductionIn silico phosphorylation of the autoinhibited form of p47(phox): insights into the mechanism of activationp47phox molecular activation for assembly of the neutrophil NADPH oxidase complex.Autoinhibitory interaction in the multidomain adaptor protein Nck: possible roles in improving specificity and functional diversity.Regulation of NOXO1 activity through reversible interactions with p22 and NOXA1.Nck adaptor proteins link Tks5 to invadopodia actin regulation and ECM degradation.p47phox, the phagocyte NADPH oxidase/NOX2 organizer: structure, phosphorylation and implication in diseasesMutations in the PX-SH3A linker of p47phox decouple PI(3,4)P2 binding from NADPH oxidase activationTripartite chimeras comprising functional domains derived from the cytosolic NADPH oxidase components p47phox, p67phox, and Rac1 elicit activator-independent superoxide production by phagocyte membranes: an essential role for anionic membrane phosphProline cis-trans isomerization controls autoinhibition of a signaling protein.The phosphoinositide-binding protein p40phox activates the NADPH oxidase during FcgammaIIA receptor-induced phagocytosis
P2860
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P2860
Molecular basis of phosphorylation-induced activation of the NADPH oxidase
description
2003 nî lūn-bûn
@nan
2003 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Molecular basis of phosphorylation-induced activation of the NADPH oxidase
@ast
Molecular basis of phosphorylation-induced activation of the NADPH oxidase
@en
Molecular basis of phosphorylation-induced activation of the NADPH oxidase
@nl
type
label
Molecular basis of phosphorylation-induced activation of the NADPH oxidase
@ast
Molecular basis of phosphorylation-induced activation of the NADPH oxidase
@en
Molecular basis of phosphorylation-induced activation of the NADPH oxidase
@nl
prefLabel
Molecular basis of phosphorylation-induced activation of the NADPH oxidase
@ast
Molecular basis of phosphorylation-induced activation of the NADPH oxidase
@en
Molecular basis of phosphorylation-induced activation of the NADPH oxidase
@nl
P3181
P1433
P1476
Molecular basis of phosphorylation-induced activation of the NADPH oxidase
@en
P2093
Karine Lapouge
Yvonne Groemping
P304
P3181
P356
10.1016/S0092-8674(03)00314-3
P407
P577
2003-05-02T00:00:00Z