Amyloid-like filaments and water-filled nanotubes formed by SOD1 mutant proteins linked to familial ALS - Test2 - elhamkhani - TriplyDB

Amyloid-like filaments and water-filled nanotubes formed by SOD1 mutant proteins linked to familial ALS

Amyloid-like filaments and water-filled nanotubes formed by SOD1 mutant proteins linked to familial ALS

http://www.wikidata.org/entity/Q27641284

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Superoxide dismutase 1 and tgSOD1 mouse spinal cord seed fibrils, suggesting a propagative cell death mechanism in amyotrophic lateral sclerosis Disulfide cross-linked protein represents a significant fraction of ALS-associated Cu, Zn-superoxide dismutase aggregates in spinal cords of model mice Chemical approaches to detect and analyze protein sulfenic acids Top-down proteomics in health and disease: challenges and opportunities Molecular dynamics using atomic-resolution structure reveal structural fluctuations that may lead to polymerization of human Cu Zn superoxide dismutase Structural Characterization of Zinc-deficient Human Superoxide Dismutase and Implications for ALS Structural and Biophysical Properties of the Pathogenic SOD1 Variant H46R/H48Q †Structural and dynamic aspects related to oligomerization of apo SOD1 and its mutants Functional features cause misfolding of the ALS-provoking enzyme SOD1 Structural and biophysical properties of metal-free pathogenic SOD1 mutants A4V and G93A Characterization of a Covalent Polysulfane Bridge in Copper−Zinc Superoxide Dismutase,Disrupted Zinc-Binding Sites in Structures of Pathogenic SOD1 Variants D124V and H80R Structures of mouse SOD1 and human/mouse SOD1 chimeras Structural switching of Cu,Zn-superoxide dismutases at loop VI: insights from the crystal structure of 2-mercaptoethanol-modified enzyme Structural Consequences of Cysteinylation of Cu/Zn-Superoxide Dismutase Three-dimensional domain swapping and supramolecular protein assembly: insights from the X-ray structure of a dimeric swapped variant of human pancreatic RNase Edge strand engineering prevents native-like aggregation in Sulfolobus solfataricus acylphosphatase The rate and equilibrium constants for a multistep reaction sequence for the aggregation of superoxide dismutase in amyotrophic lateral sclerosis Binding mode of Thioflavin T and other molecular probes in the context of amyloid fibrils-current status Parsing Disease-relevant Protein Modifications from Epiphenomena: Perspective on the Structural Basis of SOD1-Mediated ALS.Intermolecular transmission of superoxide dismutase 1 misfolding in living cells.Mutant SOD1 instability: implications for toxicity in amyotrophic lateral sclerosis.Local unfolding in a destabilized, pathogenic variant of superoxide dismutase 1 observed with H/D exchange and mass spectrometry.A common 'aggregation-prone' interface possibly participates in the self-assembly of human zona pellucida proteins.Protein aggregation and protein instability govern familial amyotrophic lateral sclerosis patient survival.The threat of instability: neurodegeneration predicted by protein destabilization and aggregation propensity Amyloidogenic regions and interaction surfaces overlap in globular proteins related to conformational diseases.Improving binding specificity of pharmacological chaperones that target mutant superoxide dismutase-1 linked to familial amyotrophic lateral sclerosis using computational methods Metal-free ALS variants of dimeric human Cu,Zn-superoxide dismutase have enhanced populations of monomeric species A prion-like mechanism for the propagated misfolding of SOD1 from in silico modeling of solvated near-native conformers DNA-triggered aggregation of copper, zinc superoxide dismutase in the presence of ascorbate.Immature copper-zinc superoxide dismutase and familial amyotrophic lateral sclerosis.Beta arcades: recurring motifs in naturally occurring and disease-related amyloid fibrils The effect of red pigment on the amyloidization of yeast proteins.Destabilization of apoprotein is insufficient to explain Cu,Zn-superoxide dismutase-linked ALS pathogenesis.Insights into SOD1-linked amyotrophic lateral sclerosis from NMR studies of Ni(2+)- and other metal-ion-substituted wild-type copper-zinc superoxide dismutases.Exposure of hydrophobic surfaces initiates aggregation of diverse ALS-causing superoxide dismutase-1 mutants.Copper-based pulsed dipolar ESR spectroscopy as a probe of protein conformation linked to disease states.Identification of a misfolded region in superoxide dismutase 1 that is exposed in amyotrophic lateral sclerosis.Aggregation modulating elements in mutant human superoxide dismutase 1.

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Amyloid-like filaments and water-filled nanotubes formed by SOD1 mutant proteins linked to familial ALS

http://www.wikidata.org/entity/Q27641284

description

2003 nî lūn-bûn

@nan

2003 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2003 թվականի հունիսին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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name

Amyloid-like filaments and wat ...... roteins linked to familial ALS

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Amyloid-like filaments and wat ...... roteins linked to familial ALS

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Amyloid-like filaments and wat ...... roteins linked to familial ALS

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type

label

Amyloid-like filaments and wat ...... roteins linked to familial ALS

@ast

Amyloid-like filaments and wat ...... roteins linked to familial ALS

@en

Amyloid-like filaments and wat ...... roteins linked to familial ALS

@nl

prefLabel

Amyloid-like filaments and wat ...... roteins linked to familial ALS

@ast

Amyloid-like filaments and wat ...... roteins linked to familial ALS

@en

Amyloid-like filaments and wat ...... roteins linked to familial ALS

@nl

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Nature structural biology

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Amyloid-like filaments and wat ...... roteins linked to familial ALS

@en

P2093

Alexander B Taylor

http://www.w3.org/2001/XMLSchema#string

Joan Selverstone Valentine

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Jorge A Rodriguez

http://www.w3.org/2001/XMLSchema#string

Lawrence J Hayward

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P John Hart

http://www.w3.org/2001/XMLSchema#string

Peter A Doucette

http://www.w3.org/2001/XMLSchema#string

Richard Strange

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S Samar Hasnain

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461-7

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scholarly article

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10.1038/NSB935

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6

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10

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Svetlana Antonyuk

Jennifer Stine Elam

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2003-06-01T00:00:00Z

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10752621

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12754496

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amyotrophic lateral sclerosis