Structure of the C-terminal domain of human La protein reveals a novel RNA recognition motif coupled to a helical nuclear retention element
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CK2 is responsible for phosphorylation of human La protein serine-366 and can modulate rpL37 5'-terminal oligopyrimidine mRNA metabolismA peptide from autoantigen La blocks poliovirus and hepatitis C virus cap-independent translation and reveals a single tyrosine critical for La RNA binding and translation stimulationMost nuclear systemic autoantigens are extremely disordered proteins: implications for the etiology of systemic autoimmunityStructural Determinant of Human La Protein Critical for Internal Initiation of Translation of Hepatitis C Virus RNAStructure of the La motif: a winged helix domain mediates RNA binding via a conserved aromatic patchStructural basis for the sequence-specific RNA-recognition mechanism of human CUG-BP1 RRM3Structural Analysis Reveals Conformational Plasticity in the Recognition of RNA 3′ Ends by the Human La ProteinNovel protein-protein contacts facilitate mRNA 3'-processing signal recognition by Rna15 and Hrp1La-Related Protein 4 Binds Poly(A), Interacts with the Poly(A)-Binding Protein MLLE Domain via a Variant PAM2w Motif, and Can Promote mRNA StabilityStructural Basis for Telomerase RNA Recognition and RNP Assembly by the Holoenzyme La Family Protein p65Structure, dynamics and RNA binding of the multi-domain splicing factor TIA-1hLARP7 C-terminal domain contains an xRRM that binds the 3' hairpin of 7SK RNAStructural basis for recognition and sequestration of UUU(OH) 3' temini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigenRNA-binding proteins: modular design for efficient functionConserved and divergent features of the structure and function of La and La-related proteins (LARPs)Conservation of a masked nuclear export activity of La proteins and its effects on tRNA maturationDeletion of the N-terminus of SF2/ASF permits RS-domain-independent pre-mRNA splicing.Structural analysis reveals the flexible C-terminus of Nop15 undergoes rearrangement to recognize a pre-ribosomal RNA folding intermediate.Mammalian peptidylglycine alpha-amidating monooxygenase mRNA expression can be modulated by the La autoantigenLa autoantigen mediates oxidant induced de novo Nrf2 protein translationStructure of Pfu Pop5, an archaeal RNase P protein.An intrinsically disordered C terminus allows the La protein to assist the biogenesis of diverse noncoding RNA precursorsSynergic interplay of the La motif, RRM1 and the interdomain linker of LARP6 in the recognition of collagen mRNA expands the RNA binding repertoire of the La module.Novel RNA chaperone domain of RNA-binding protein La is regulated by AKT phosphorylationNMR structure of the three quasi RNA recognition motifs (qRRMs) of human hnRNP F and interaction studies with Bcl-x G-tract RNA: a novel mode of RNA recognition.Analysis of the interaction with the hepatitis C virus mRNA reveals an alternative mode of RNA recognition by the human La protein(1)H, (15)N and (13)C chemical shift assignments of the La motif and RRM1 from human LARP6.NMR in pharmacokinetic and pharmacodynamic profiling.The role of the C-terminal helix of U1A protein in the interaction with U1hpII RNA.7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate developmentNonphosphorylated human La antigen interacts with nucleolin at nucleolar sites involved in rRNA biogenesis.Drug discovery for a new generation of covalent drugs.xRRM: a new class of RRM found in the telomerase La family protein p65.Heterodimerization of the human RNase P/MRP subunits Rpp20 and Rpp25 is a prerequisite for interaction with the P3 arm of RNase MRP RNA.RNA chaperone activity of human La protein is mediated by variant RNA recognition motifMyocardial ischemic reperfusion induces de novo Nrf2 protein translation.A comprehensive analysis of the La-motif protein superfamily.A bona fide La protein is required for embryogenesis in Arabidopsis thaliana.The architecture of Tetrahymena telomerase holoenzyme.Platelet phosphorylated TDP-43: an exploratory study for a peripheral surrogate biomarker development for Alzheimer's disease.
P2860
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P2860
Structure of the C-terminal domain of human La protein reveals a novel RNA recognition motif coupled to a helical nuclear retention element
description
2003 nî lūn-bûn
@nan
2003 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Structure of the C-terminal do ...... ical nuclear retention element
@ast
Structure of the C-terminal do ...... ical nuclear retention element
@en
Structure of the C-terminal do ...... ical nuclear retention element
@nl
type
label
Structure of the C-terminal do ...... ical nuclear retention element
@ast
Structure of the C-terminal do ...... ical nuclear retention element
@en
Structure of the C-terminal do ...... ical nuclear retention element
@nl
prefLabel
Structure of the C-terminal do ...... ical nuclear retention element
@ast
Structure of the C-terminal do ...... ical nuclear retention element
@en
Structure of the C-terminal do ...... ical nuclear retention element
@nl
P2093
P50
P921
P1433
P1476
Structure of the C-terminal do ...... ical nuclear retention element
@en
P2093
Amanda Jacks
Ioannis Manolaridis
Jeff Babon
Peter D Cary
P304
P356
10.1016/S0969-2126(03)00121-7
P577
2003-07-01T00:00:00Z