Structural basis of proline-specific exopeptidase activity as observed in human dipeptidyl peptidase-IV
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One site mutation disrupts dimer formation in human DPP-IV proteinsDipeptidyl peptidases 8 and 9: specificity and molecular characterization compared with dipeptidyl peptidase IVCrystal structure of human dipeptidyl peptidase IV in complex with a decapeptide reveals details on substrate specificity and tetrahedral intermediate formationThe first structure of dipeptidyl-peptidase III provides insight into the catalytic mechanism and mode of substrate bindingInduced-fit mechanism for prolyl endopeptidase.Structures of Human DPP7 Reveal the Molecular Basis of Specific Inhibition and the Architectural Diversity of Proline-Specific PeptidasesS46 Peptidases are the First Exopeptidases to be Members of Clan PACatalytically distinct states captured in a crystal lattice: the substrate-bound and scavenger states of acylaminoacyl peptidase and their implications for functionalityAnagliptin, a potent dipeptidyl peptidase IV inhibitor: its single-crystal structure and enzyme interactionsDegradation and Stabilization of Peptide Hormones in Human Blood SpecimensFunctional similarities between the dictyostelium protein AprA and the human protein dipeptidyl-peptidase IV.Selective inhibition of fibroblast activation protein protease based on dipeptide substrate specificity.Molecular cloning of the precursor polypeptide of mastoparan B and its putative processing enzyme, dipeptidyl peptidase IV, from the black-bellied hornet, Vespa basalis.How the Same Core Catalytic Machinery Catalyzes 17 Different Reactions: the Serine-Histidine-Aspartate Catalytic Triad of α/β-Hydrolase Fold Enzymes.Isolation of dipeptidyl peptidase IV (DP 4) isoforms from porcine kidney by preparative isoelectric focusing to improve crystallization.Structural and mechanistic analysis of two prolyl endopeptidases: role of interdomain dynamics in catalysis and specificity.Generation of dipeptidyl peptidase-IV-inhibiting peptides from β-lactoglobulin secreted by Lactococcus lactisThe dimeric transmembrane domain of prolyl dipeptidase DPP-IV contributes to its quaternary structure and enzymatic activities.Investigation of the dimer interface and substrate specificity of prolyl dipeptidase DPP8.Identification and partial characterization of the enzyme of omega: one of five putative DPP IV genes in Drosophila melanogasterThe metabolic serine hydrolases and their functions in mammalian physiology and disease.Inhibitors of dipeptidyl peptidase IV: a novel approach for the prevention and treatment of Type 2 diabetes?Crystallization and preliminary crystallographic analysis of porcine acylaminoacyl peptidase.Comprehensive analysis of the Co-structures of dipeptidyl peptidase IV and its inhibitorHeparin oligosaccharides inhibit chemokine (CXC motif) ligand 12 (CXCL12) cardioprotection by binding orthogonal to the dimerization interface, promoting oligomerization, and competing with the chemokine (CXC motif) receptor 4 (CXCR4) N terminusMonitoring of the effects of transfection with baculovirus on Sf9 cell line and expression of human dipeptidyl peptidase IV.Overview of food products and dietary constituents with antidiabetic properties and their putative mechanisms of action: a natural approach to complement pharmacotherapy in the management of diabetes.Food protein-derived bioactive peptides in management of type 2 diabetes.Flavanol concentrations do not predict dipeptidyl peptidase-IV inhibitory activities of four cocoas with different processing histories.Crystallization and preliminary X-ray crystallographic studies of dipeptidyl peptidase 11 from Porphyromonas gingivalis.Crystallization and preliminary X-ray characterization of prolyl tripeptidyl aminopeptidase from Porphyromonas gingivalis.Selective Homogeneous Assay for Circulating Endopeptidase Fibroblast Activation Protein (FAP).A novel SUMO1-specific interacting motif in dipeptidyl peptidase 9 (DPP9) that is important for enzymatic regulation.Observation of a tetrahedral reaction intermediate in the HIV-1 protease-substrate complex.Tyrosine 547 constitutes an essential part of the catalytic mechanism of dipeptidyl peptidase IV.Crystal structure of CD26/dipeptidyl-peptidase IV in complex with adenosine deaminase reveals a highly amphiphilic interface.The crystal structure of human dipeptidyl peptidase IV (DPPIV) complex with diprotin A.His507 of acylaminoacyl peptidase stabilizes the active site conformation, not the catalytic intermediate.Crystal structures of HIV-1 Tat-derived nonapeptides Tat-(1-9) and Trp2-Tat-(1-9) bound to the active site of dipeptidyl-peptidase IV (CD26).Peptide substrate profiling defines fibroblast activation protein as an endopeptidase of strict Gly(2)-Pro(1)-cleaving specificity.
P2860
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P2860
Structural basis of proline-specific exopeptidase activity as observed in human dipeptidyl peptidase-IV
description
2003 nî lūn-bûn
@nan
2003 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Structural basis of proline-sp ...... human dipeptidyl peptidase-IV
@ast
Structural basis of proline-sp ...... human dipeptidyl peptidase-IV
@en
Structural basis of proline-sp ...... human dipeptidyl peptidase-IV
@nl
type
label
Structural basis of proline-sp ...... human dipeptidyl peptidase-IV
@ast
Structural basis of proline-sp ...... human dipeptidyl peptidase-IV
@en
Structural basis of proline-sp ...... human dipeptidyl peptidase-IV
@nl
prefLabel
Structural basis of proline-sp ...... human dipeptidyl peptidase-IV
@ast
Structural basis of proline-sp ...... human dipeptidyl peptidase-IV
@en
Structural basis of proline-sp ...... human dipeptidyl peptidase-IV
@nl
P2093
P3181
P1433
P1476
Structural basis of proline-sp ...... human dipeptidyl peptidase-IV
@en
P2093
Bernd Löffler
Martine Stihle
Michael Hennig
Ralf Thoma
Walter Huber
P304
P3181
P356
10.1016/S0969-2126(03)00160-6
P577
2003-08-01T00:00:00Z