Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130
about
Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 systemThe structure of interleukin-23 reveals the molecular basis of p40 subunit sharing with interleukin-12A model of the ternary complex of interleukin-10 with its soluble receptors.Insights into cytokine-receptor interactions from cytokine engineeringHigh affinity antigen recognition of the dual specific variants of herceptin is entropy-driven in spite of structural plasticityAn unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptorStructural Organization of a Full-Length gp130/LIF-R Cytokine Receptor Transmembrane ComplexThe mechanism of shared but distinct CSF-1R signaling by the non-homologous cytokines IL-34 and CSF-1The structure of human interleukin-11 reveals receptor-binding site features and structural differences from interleukin-6Leukemia inhibitory factor (LIF)The N-terminal cytokine binding domain of LIFR is required for CNTF binding and signalingThe molecular basis of TCR germline bias for MHC is surprisingly simpleRosettaBackrub--a web server for flexible backbone protein structure modeling and designN-linked glycosylation is essential for the stability but not the signaling function of the interleukin-6 signal transducer glycoprotein 130.A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor.Crystal structure of the entire ectodomain of gp130: insights into the molecular assembly of the tall cytokine receptor complexesStructures and biological functions of IL-31 and IL-31 receptors.Ligand-induced architecture of the leptin receptor signaling complexStructural biology of shared cytokine receptors.The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease.The high- and low-affinity receptor binding sites of growth hormone are allosterically coupledMolecular interactions within the IL-6/IL-12 cytokine/receptor superfamily.Smarter drugs: a focus on pan-specific monoclonal antibodies.Changes of the cytokine profile in inflammatory bowel diseases.gp130: a promising drug target for cancer therapy.Multifarious determinants of cytokine receptor signaling specificity.Cytokines in Endocrine Dysfunction of Plasma Cell Disorders.Non-core region modulates interleukin-11 signaling activity: generation of agonist and antagonist variants.Novel inhibitors for murine and human leukemia inhibitory factor based on fused soluble receptors.Characterization of the Interleukin (IL)-6 Inhibitor IL-6-RFP: fused receptor domains act as high affinity cytokine-binding proteins.Molecular and functional characterization of a soluble form of oncostatin M/interleukin-31 shared receptor.The IFN-λ-IFN-λR1-IL-10Rβ Complex Reveals Structural Features Underlying Type III IFN Functional Plasticity.Systematic mutation and thermodynamic analysis of central tyrosine pairs in polyspecific NKG2D receptor interactions.The dynamics of signal triggering in a gp130-receptor complex.Structural snapshots of full-length Jak1, a transmembrane gp130/IL-6/IL-6Rα cytokine receptor complex, and the receptor-Jak1 holocomplex.Unraveling viral interleukin-6 binding to gp130 and activation of STAT-signaling pathways independently of the interleukin-6 receptor.Charged residues at protein interaction interfaces: unexpected conservation and orchestrated divergence.Ciliary neurotrophic factor, cardiotrophin-like cytokine, and neuropoietin share a conserved binding site on the ciliary neurotrophic factor receptor alpha chain.Dynamics of the gp130 cytokine complex: a model for assembly on the cellular membrane.
P2860
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P2860
Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130
description
2003 nî lūn-bûn
@nan
2003 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Convergent mechanisms for reco ...... hared signaling receptor gp130
@ast
Convergent mechanisms for reco ...... hared signaling receptor gp130
@en
Convergent mechanisms for reco ...... hared signaling receptor gp130
@nl
type
label
Convergent mechanisms for reco ...... hared signaling receptor gp130
@ast
Convergent mechanisms for reco ...... hared signaling receptor gp130
@en
Convergent mechanisms for reco ...... hared signaling receptor gp130
@nl
prefLabel
Convergent mechanisms for reco ...... hared signaling receptor gp130
@ast
Convergent mechanisms for reco ...... hared signaling receptor gp130
@en
Convergent mechanisms for reco ...... hared signaling receptor gp130
@nl
P50
P1433
P1476
Convergent mechanisms for reco ...... hared signaling receptor gp130
@en
P2093
K Christopher Garcia
Martin J Boulanger
P304
P356
10.1016/S1097-2765(03)00365-4
P577
2003-09-01T00:00:00Z