Structures of gamma-aminobutyric acid (GABA) aminotransferase, a pyridoxal 5'-phosphate, and [2Fe-2S] cluster-containing enzyme, complexed with gamma-ethynyl-GABA and with the antiepilepsy drug vigabatrin

Structures of gamma-aminobutyric acid (GABA) aminotransferase, a pyridoxal 5'-phosphate, and [2Fe-2S] cluster-containing enzyme, complexed with gamma-ethynyl-GABA and with the antiepilepsy drug vigabatrin

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Q27642315

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Redox-switch modulation of human SSADH by dynamic catalytic loop Structural Characterization of the Mycobacterium tuberculosis Biotin Biosynthesis Enzymes 7,8-Diaminopelargonic Acid Synthase and Dethiobiotin Synthetase,Structural Determinants of the -Selectivity of a Bacterial Aminotransferase Structures of a γ-aminobutyrate (GABA) transaminase from thes-triazine-degrading organismArthrobacter aurescensTC1 in complex with PLP and with its external aldimine PLP–GABA adduct Crystal structure of Bacillus subtilis GabR, an autorepressor and transcriptional activator of gabT From protein structure to function via single crystal optical spectroscopy Poisoning pyridoxal 5-phosphate-dependent enzymes: a new strategy to target the malaria parasite Plasmodium falciparum Clinical trial of vigabatrin as adjunctive therapy in children with refractory epilepsy.A neuron-glia interaction involving GABA transaminase contributes to sleep loss in sleepless mutants The 2011 E. B. Hershberg award for important discoveries in medicinally active substances: (1S,3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a GABA aminotransferase inactivator and new treatment for drug addiction and infantile s Synthesis of quaternary amino acids bearing a (2'Z)-fluorovinyl alpha-branch: potential PLP enzyme inactivators.Protein-Templated Fragment Ligations-From Molecular Recognition to Drug Discovery.Mechanisms and structures of vitamin B(6)-dependent enzymes involved in deoxy sugar biosynthesis.Targeting cystalysin, a virulence factor of treponema denticola-supported periodontitis.Mechanism of inactivation of γ-aminobutyric acid aminotransferase by (1S,3S)-3-amino-4-difluoromethylene-1-cyclopentanoic acid (CPP-115)Use of knowledge-based restraints in phenix.refine to improve macromolecular refinement at low resolution.Mechanism of Inactivation of GABA Aminotransferase by (E)- and (Z)-(1S,3S)-3-Amino-4-fluoromethylenyl-1-cyclopentanoic Acid.Probing the steric requirements of the γ-aminobutyric acid aminotransferase active site with fluorinated analogues of vigabatrin.Synthesis and evaluation of novel aromatic substrates and competitive inhibitors of GABA aminotransferase.A retro-evolution study of CDP-6-deoxy-D-glycero-L-threo-4-hexulose-3-dehydrase (E1) from Yersinia pseudotuberculosis: implications for C-3 deoxygenation in the biosynthesis of 3,6-dideoxyhexoses.Enantiomers of 4-amino-3-fluorobutanoic acid as substrates for gamma-aminobutyric acid aminotransferase. Conformational probes for GABA binding Vigabatrin: a comprehensive review of drug properties including clinical updates following recent FDA approval.Ornithine aminotransferase versus GABA aminotransferase: implications for the design of new anticancer drugs.Privileged Electrophile Sensors: A Resource for Covalent Drug Development.Chemogenomics of pyridoxal 5'-phosphate dependent enzymes.Use of Fluorinated Functionality in Enzyme Inhibitor Development: Mechanistic and Analytical Advantages Synchronization by food access modifies the daily variations in expression and activity of liver GABA transaminase.A formal [3,3]-sigmatropic rearrangement route to quaternary alpha-vinyl amino acids: use of allylic N-PMP trifluoroacetimidates.Examination of the new alpha-(2'Z-fluoro)vinyl trigger with lysine decarboxylase: the absolute stereochemistry dictates the reaction course.Vitamin B6-dependent enzymes in the human malaria parasite Plasmodium falciparum: a druggable target?Cloning, purification, crystallization and preliminary X-ray crystallographic analysis of the biosynthetic N-acetylornithine aminotransferases from Salmonella typhimurium and Escherichia coli PLP and GABA trigger GabR-mediated transcription regulation in Bacillus subtilis via external aldimine formation Overexpression, purification and crystallization of lysine epsilon-aminotransferase (Rv3290c) from Mycobacterium tuberculosis H37Rv.Docking studies of phthalimide pharmacophore as a sodium channel blocker.Loss-of-function mutations in ISCA2 disrupt 4Fe-4S cluster machinery and cause a fatal leukodystrophy with hyperglycinemia and mtDNA depletion.Metabolic pathway of 6-aminohexanoate in the nylon oligomer-degrading bacterium Arthrobacter sp. KI72: identification of the enzymes responsible for the conversion of 6-aminohexanoate to adipate.Design and Mechanism of (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic Acid, a Highly Potent γ-Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Addiction.Molecular dynamics simulations of apo, holo, and inactivator bound GABA-at reveal the role of active site residues in PLP dependent enzymes.Design, synthesis, and biological evaluation of hydrazone incorporated 1,2,4-triazines as anticonvulsant agents.Theoretical studies on the inactivation mechanism of γ-aminobutyric acid aminotransferase.

P2860

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P2860

Structures of gamma-aminobutyric acid (GABA) aminotransferase, a pyridoxal 5'-phosphate, and [2Fe-2S] cluster-containing enzyme, complexed with gamma-ethynyl-GABA and with the antiepilepsy drug vigabatrin

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2004 nî lūn-bûn

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2004 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2004年の論文

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