The Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37)
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The heat shock protein 90-CDC37 chaperone complex is required for signaling by types I and II interferonsA proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting proteinStructural and functional coupling of Hsp90- and Sgt1-centred multi-protein complexesMechanisms of Hsp90 regulationReview: The HSP90 molecular chaperone-an enigmatic ATPaseThe 'active life' of Hsp90 complexesSmall Molecule Inhibitors to Disrupt Protein-protein Interactions of Heat Shock Protein 90 Chaperone MachineryFunctions of the Hsp90 chaperone system: lifting client proteins to new heightsThe human Cdc37.Hsp90 complex studied by heteronuclear NMR spectroscopyStructural Basis for Assembly of Hsp90-Sgt1-CHORD Protein Complexes: Implications for Chaperoning of NLR Innate Immunity ReceptorsThe C-terminal domain of human Cdc37 studied by solution NMRAtomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinaseChaperone ligand-discrimination by the TPR-domain protein Tah1.Sgt1p is a unique co-chaperone that acts as a client adaptor to link Hsp90 to Skp1p.Intra- and intermonomer interactions are required to synergistically facilitate ATP hydrolysis in Hsp90.Systematic Mutant Analyses Elucidate General and Client-Specific Aspects of Hsp90 FunctionInvolvement of FKBP6 in hepatitis C virus replicationRole of acetylation and extracellular location of heat shock protein 90alpha in tumor cell invasionPosttranslational modification and conformational state of heat shock protein 90 differentially affect binding of chemically diverse small molecule inhibitorsA primate specific extra domain in the molecular chaperone Hsp90Exploring the Functional Complementation between Grp94 and Hsp90Glutathione protects cells against arsenite-induced toxicityGambogic acid identifies an isoform-specific druggable pocket in the middle domain of Hsp90βCanonical and kinase activity-independent mechanisms for extracellular signal-regulated kinase 5 (ERK5) nuclear translocation require dissociation of Hsp90 from the ERK5-Cdc37 complexCrystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complexPathways of chaperone-mediated protein folding in the cytosolAllosteric regulation of the Hsp90 dynamics and stability by client recruiter cochaperones: protein structure network modelingDynamic Interaction of Hsp90 with Its Client Protein p53.The Schizosaccharomyces pombe Cdc7 protein kinase required for septum formation is a client protein of Cdc37.An AlphaScreen-based high-throughput screen to identify inhibitors of Hsp90-cochaperone interaction.Hsp90/Cdc37 chaperone/co-chaperone complex, a novel junction anticancer target elucidated by the mode of action of herbal drug Withaferin ANovel Hsp90 partners discovered using complementary proteomic approaches.Split Renilla luciferase protein fragment-assisted complementation (SRL-PFAC) to characterize Hsp90-Cdc37 complex and identify critical residues in protein/protein interactions.Cdc37 engages in stable, S14A mutation-reinforced association with the most atypical member of the yeast kinome, Cdk-activating kinase (Cak1).Probing molecular mechanisms of the Hsp90 chaperone: biophysical modeling identifies key regulators of functional dynamics.Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperoneATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system.Ligand-induced conformational shift in the N-terminal domain of GRP94, an Hsp90 chaperone.MEK inhibition potentiates the activity of Hsp90 inhibitor 17-AAG against pancreatic cancer cells.Cell surface Cdc37 participates in extracellular HSP90 mediated cancer cell invasion
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P2860
The Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37)
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2004 nî lūn-bûn
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2004 թուականի Յունուարին հրատարակուած գիտական յօդուած
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2004 թվականի հունվարին հրատարակված գիտական հոդված
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2004年の論文
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2004年論文
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2004年論文
@zh-hant
2004年論文
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2004年論文
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2004年論文
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2004年论文
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name
The Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37)
@ast
The Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37)
@en
The Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37)
@nl
type
label
The Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37)
@ast
The Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37)
@en
The Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37)
@nl
prefLabel
The Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37)
@ast
The Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37)
@en
The Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37)
@nl
P2093
P50
P3181
P1433
P1476
The Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37)
@en
P2093
Barry Panaretou
Cara K Vaughan
Laurence H Pearl
Peter W Piper
S Mark Roe
P3181
P356
10.1016/S0092-8674(03)01027-4
P407
P577
2004-01-01T00:00:00Z