Design, synthesis, and crystal structure of hydroxyethyl secondary amine-based peptidomimetic inhibitors of human beta-secretase
about
Potent memapsin 2 (β-secretase) inhibitors: Design, synthesis, protein-ligand X-ray structure, and in vivo evaluationFlexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulationsDiscovery of potent beta-secretase (bace-1) inhibitors by the synthesis of isophthalamide-containing hybridsPotent BACE-1 inhibitor design using pharmacophore modeling, in silico screening and molecular docking studiesDesign, synthesis, and biological evaluation of novel fluorinated ethanolamines.BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's diseaseExploring the binding of BACE-1 inhibitors using comparative binding energy analysis (COMBINE).Alzheimer's disease: identification and development of β-secretase (BACE-1) binding fragments and inhibitors by dynamic ligation screening (DLS).Targets for AD treatment: conflicting messages from γ-secretase inhibitorsDeveloping β-secretase inhibitors for treatment of Alzheimer's disease.Pharmacological Treatment of Alzheimer's Disease: Is it Progressing Adequately?beta-Secretase as a therapeutic target for Alzheimer's disease.AβPP-selective BACE inhibitors (ASBI): novel class of therapeutic agents for alzheimer's disease.A medicinal chemist's guide to molecular interactionsAdvances in the identification of β-secretase inhibitors.The structural evolution of β-secretase inhibitors: a focus on the development of small-molecule inhibitors.New directions for protease inhibitors directed drug discovery.Factors Influencing the Potency of Alzheimer Inhibitors: Computational and Docking Studies.Looking Back, Looking Forward at Halogen Bonding in Drug Discovery.Highly Stereoselective Asymmetric Aldol Routes to tert-Butyl-2-(3,5-difluorophenyl)-1-oxiran-2-yl)ethyl)carbamates: Building Blocks for Novel Protease Inhibitors.Design, synthesis, and X-ray structural studies of BACE-1 inhibitors containing substituted 2-oxopiperazines as P1'-P2' ligands.
P2860
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P2860
Design, synthesis, and crystal structure of hydroxyethyl secondary amine-based peptidomimetic inhibitors of human beta-secretase
description
2007 nî lūn-bûn
@nan
2007 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Design, synthesis, and crystal ...... bitors of human beta-secretase
@ast
Design, synthesis, and crystal ...... bitors of human beta-secretase
@en
Design, synthesis, and crystal ...... bitors of human beta-secretase
@nl
type
label
Design, synthesis, and crystal ...... bitors of human beta-secretase
@ast
Design, synthesis, and crystal ...... bitors of human beta-secretase
@en
Design, synthesis, and crystal ...... bitors of human beta-secretase
@nl
prefLabel
Design, synthesis, and crystal ...... bitors of human beta-secretase
@ast
Design, synthesis, and crystal ...... bitors of human beta-secretase
@en
Design, synthesis, and crystal ...... bitors of human beta-secretase
@nl
P2093
P356
P1476
Design, synthesis, and crystal ...... bitors of human beta-secretase
@en
P2093
Alfredo G Tomasselli
D Bryan Prince
Danielle D Woods
Donna J Paddock
Eugene D Thorsett
John A Tucker
Joseph B Moon
Louis Brogley
Michael Bienkowski
Michael S Dappen
P304
P356
10.1021/JM061242Y
P407
P577
2007-02-22T00:00:00Z