Structure of fungal fatty acid synthase and implications for iterative substrate shuttling
about
Genome characterization of the oleaginous fungus Mortierella alpinaMechanism and substrate recognition of human holo ACP synthaseStudying protein complexes by the yeast two-hybrid systemDirect structural insight into the substrate-shuttling mechanism of yeast fatty acid synthase by electron cryomicroscopyStructural Basis for Different Specificities of Acyltransferases Associated with the Human Cytosolic and Mitochondrial Fatty Acid SynthasesCrystal structure of enoyl-acyl carrier protein reductase (FabK) fromStreptococcus pneumoniaereveals the binding mode of an inhibitorDynamic thiolation–thioesterase structure of a non-ribosomal peptide synthetaseStructural basis for the selectivity of the external thioesterase of the surfactin synthetaseInhibition of the fungal fatty acid synthase type I multienzyme complexThe crystal structure of a mammalian fatty acid synthaseCrystal structure of DltA. Implications for the reaction mechanism of non-ribosomal peptide synthetase adenylation domainsDihydroorotase from the Hyperthermophile Aquifiex aeolicus Is Activated by Stoichiometric Association with Aspartate Transcarbamoylase and Forms a One-Pot Reactor for Pyrimidine Biosynthesis † ‡Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesisSolution Structures of the Acyl Carrier Protein Domain from the Highly Reducing Type I Iterative Polyketide Synthase CalE8Biochemical and Structural Study of the Atypical Acyltransferase Domain from the Mycobacterial Polyketide Synthase Pks13Structural characterization and comparison of three acyl-carrier-protein synthases from pathogenic bacteriaCrystal structure and biochemical studies of the trans-acting polyketide enoyl reductase LovC from lovastatin biosynthesisThe role of distant mutations and allosteric regulation on LovD active site dynamicsA human fatty acid synthase inhibitor binds β-ketoacyl reductase in the keto-substrate siteUsing modern tools to probe the structure-function relationship of fatty acid synthasesAntibacterial targets in fatty acid biosynthesisConformational flexibility of metazoan fatty acid synthase enables catalysisGenomics and Transcriptomics Analyses of the Oil-Accumulating Basidiomycete Yeast Trichosporon oleaginosus: Insights into Substrate Utilization and Alternative Evolutionary Trajectories of Fungal Mating SystemsAnalysis of proteins with the 'hot dog' fold: prediction of function and identification of catalytic residues of hypothetical proteins.Biochemical evidence for conformational changes in the cross-talk between adenylation and peptidyl-carrier protein domains of nonribosomal peptide synthetases.Fungal polyketide engineering comes of age.A multi-omic map of the lipid-producing yeast Rhodosporidium toruloidesDemonstration of starter unit interprotein transfer from a fatty acid synthase to a multidomain, nonreducing polyketide synthase.Acyl-carrier protein-phosphopantetheinyltransferase partnerships in fungal fatty acid synthases.Triclosan antagonizes fluconazole activity against Candida albicans.Cryo-EM structure of fatty acid synthase (FAS) from Rhodosporidium toruloides provides insights into the evolutionary development of fungal FAS.Molecular basis for the inhibition of β-hydroxyacyl-ACP dehydratase HadAB complex from Mycobacterium tuberculosis by flavonoid inhibitors.Solution Structure of a Nonribosomal Peptide Synthetase Carrier Protein Loaded with Its Substrate Reveals Transient, Well-Defined ContactsDirect transfer of starter substrates from type I fatty acid synthase to type III polyketide synthases in phenolic lipid synthesis.The type I fatty acid and polyketide synthases: a tale of two megasynthasesActive site comparisons and catalytic mechanisms of the hot dog superfamily.Engineering Yarrowia lipolytica as a platform for synthesis of drop-in transportation fuels and oleochemicalsDiversity in enoyl-acyl carrier protein reductases.Structural insights into nonribosomal peptide enzymatic assembly linesCrystal structure of FabZ-ACP complex reveals a dynamic seesaw-like catalytic mechanism of dehydratase in fatty acid biosynthesis.
P2860
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P2860
Structure of fungal fatty acid synthase and implications for iterative substrate shuttling
description
2007 nî lūn-bûn
@nan
2007 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
name
Structure of fungal fatty acid ...... iterative substrate shuttling
@ast
Structure of fungal fatty acid ...... iterative substrate shuttling
@en
Structure of fungal fatty acid ...... iterative substrate shuttling
@nl
type
label
Structure of fungal fatty acid ...... iterative substrate shuttling
@ast
Structure of fungal fatty acid ...... iterative substrate shuttling
@en
Structure of fungal fatty acid ...... iterative substrate shuttling
@nl
prefLabel
Structure of fungal fatty acid ...... iterative substrate shuttling
@ast
Structure of fungal fatty acid ...... iterative substrate shuttling
@en
Structure of fungal fatty acid ...... iterative substrate shuttling
@nl
P2093
P356
P1433
P1476
Structure of fungal fatty acid ...... iterative substrate shuttling
@en
P2093
Bohdan Mikolásek
Christian Frick
Daniel Boehringer
Marc Leibundgut
Simon Jenni
P304
P356
10.1126/SCIENCE.1138248
P407
P50
P577
2007-04-13T00:00:00Z