Structure of calcineurin in complex with PVIVIT peptide: portrait of a low-affinity signalling interaction
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Phosphorylation-dependent binding of 14-3-3 proteins controls TRESK regulationDirect association of the unique C-terminal tail of transmembrane AMPA receptor regulatory protein γ-8 with calcineurinNa(+)/H(+) exchanger 1 directly binds to calcineurin A and activates downstream NFAT signaling, leading to cardiomyocyte hypertrophyTherapeutic strategies for anchored kinases and phosphatases: exploiting short linear motifs and intrinsic disorderShort linear motifs - ex nihilo evolution of protein regulationThe Molecular Mechanism of Substrate Engagement and Immunosuppressant Inhibition of CalcineurinBalanced interactions of calcineurin with AKAP79 regulate Ca2+–calcineurin–NFAT signalingRegulation of the phosphatase PP2B by protein-protein interactionsPhosphorylation of Calcineurin at a novel serine-proline rich region orchestrates hyphal growth and virulence in Aspergillus fumigatusCalcineurin Undergoes a Conformational Switch Evoked via Peptidyl-Prolyl IsomerizationTRESK background K(+) channel is inhibited by phosphorylation via two distinct pathways.Post-translational regulation of calsarcin-1 during pressure overload-induced cardiac hypertrophyDirect evidence for calcineurin binding to the exon-7 loop of the sodium-bicarbonate cotransporter NBCn1.High-throughput screening of one-bead-one-compound libraries: identification of cyclic peptidyl inhibitors against calcineurin/NFAT interaction.Conformational isomers of calcineurin follow distinct dissociation pathways.The calcineurin signaling network evolves via conserved kinase-phosphatase modules that transcend substrate identityStructure-based optimization of a peptidyl inhibitor against calcineurin-nuclear factor of activated T cell (NFAT) interaction.The LQLP calcineurin docking site is a major determinant of the calcium-dependent activation of human TRESK background K+ channel.The Crz1/Sp1 transcription factor of Cryptococcus neoformans is activated by calcineurin and regulates cell wall integrity.Calcineurin-mediated regulation of hyphal growth, septation, and virulence in Aspergillus fumigatus.Architecture and dynamics of an A-kinase anchoring protein 79 (AKAP79) signaling complexNMR resonance assignments of the catalytic domain of human serine/threonine phosphatase calcineurin in unligated and PVIVIT-peptide-bound statesStructural basis for protein phosphatase 1 regulation and specificityCrystallization and preliminary crystallographic study of a trypsin-resistant catalytic domain of human calcineurin.Novel motif in calcineurin catalytic subunit is required for septal localization of calcineurin in Aspergillus fumigatusCooperative autoinhibition and multi-level activation mechanisms of calcineurinThe RCAN carboxyl end mediates calcineurin docking-dependent inhibition via a site that dictates binding to substrates and regulators.Calmodulin-dependent phosphatase, kinases, and transcriptional corepressors involved in T-cell activationRequirement for balanced Ca/NFAT signaling in hematopoietic and embryonic development.Local cAMP signaling in disease at a glanceTransient Receptor Potential Vanilloid 1 Regulates Mitochondrial Membrane Potential and Myocardial Reperfusion Injury.Investigating the human Calcineurin Interaction Network using the πɸLxVP SLiM.Novel inhibitors of the calcineurin/NFATc hub - alternatives to CsA and FK506?Interaction of calcineurin with substrates and targeting proteins.A frontier in the understanding of synaptic plasticity: solving the structure of the postsynaptic density.Functional diversity and pharmacological profiles of the FKBPs and their complexes with small natural ligands.Transient disorder: Calcineurin as an example.Catalytic scaffolds for phosphoryl group transfer.Expanding the PP2A Interactome by Defining a B56-Specific SLiM.Inhibiting the calcineurin-NFAT (nuclear factor of activated T cells) signaling pathway with a regulator of calcineurin-derived peptide without affecting general calcineurin phosphatase activity.
P2860
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P2860
Structure of calcineurin in complex with PVIVIT peptide: portrait of a low-affinity signalling interaction
description
2007 nî lūn-bûn
@nan
2007 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Structure of calcineurin in co ...... ffinity signalling interaction
@ast
Structure of calcineurin in co ...... ffinity signalling interaction
@en
Structure of calcineurin in co ...... ffinity signalling interaction
@nl
type
label
Structure of calcineurin in co ...... ffinity signalling interaction
@ast
Structure of calcineurin in co ...... ffinity signalling interaction
@en
Structure of calcineurin in co ...... ffinity signalling interaction
@nl
prefLabel
Structure of calcineurin in co ...... ffinity signalling interaction
@ast
Structure of calcineurin in co ...... ffinity signalling interaction
@en
Structure of calcineurin in co ...... ffinity signalling interaction
@nl
P2093
P3181
P1476
Structure of calcineurin in co ...... ffinity signalling interaction
@en
P2093
Anjana Rao
Huiming Li
Patrick G Hogan
Stephen C Harrison
P304
P3181
P356
10.1016/J.JMB.2007.04.032
P407
P577
2007-06-22T00:00:00Z