Catalysis-associated conformational changes revealed by human CD38 complexed with a non-hydrolyzable substrate analog

Catalysis-associated conformational changes revealed by human CD38 complexed with a non-hydrolyzable substrate analog

Item
http://www.wikidata.org/entity/Q27646429
Conformational Closure of the Catalytic Site of Human CD38 Induced by CalciumStructural Basis for Enzymatic Evolution from a Dedicated ADP-ribosyl Cyclase to a Multifunctional NAD HydrolaseDynamic Conformations of the CD38-Mediated NAD Cyclization Captured in a Single CrystalCD38 Structure-Based Inhibitor Design Using the N1-Cyclic Inosine 5'-Diphosphate Ribose TemplateEvolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology'Click cyclic ADP-ribose': a neutral second messenger mimic.Design, synthesis and biological characterization of novel inhibitors of CD38.Cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate (NAADP) as messengers for calcium mobilization.Synthesis of cyclic adenosine 5'-diphosphate ribose analogues: a C2'endo/syn "southern" ribose conformation underlies activity at the sea urchin cADPR receptor.Cyclic adenosine 5'-diphosphate ribose analogs without a "southern" ribose inhibit ADP-ribosyl cyclase-hydrolase CD38.Expression of CD38 with intracellular enzymatic activity: a possible explanation for the insulin release induced by intracellular cADPR.Aberrant cyclization affords a C-6 modified cyclic adenosine 5'-diphosphoribose analogue with biological activity in Jurkat T cells.Total synthesis of a cyclic adenosine 5'-diphosphate ribose receptor agonist.Second messenger analogues highlight unexpected substrate sensitivity of CD38: total synthesis of the hybrid "L-cyclic inosine 5'-diphosphate ribose".Comparative Analysis of Pharmacophore Features and Quantitative Structure-Activity Relationships for CD38 Covalent and Non-covalent Inhibitors.
P2860

Catalysis-associated conformational changes revealed by human CD38 complexed with a non-hydrolyzable substrate analog

Item
http://www.wikidata.org/entity/Q27646429
description
2007 nî lūn-bûn
@nan
2007 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2007年の論文
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2007年論文
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2007年論文
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2007年論文
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2007年論文
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2007年論文
@zh-tw
2007年论文
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name
Catalysis-associated conformat ...... -hydrolyzable substrate analog
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Catalysis-associated conformat ...... -hydrolyzable substrate analog
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Catalysis-associated conformat ...... -hydrolyzable substrate analog
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type
label
Catalysis-associated conformat ...... -hydrolyzable substrate analog
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Catalysis-associated conformat ...... -hydrolyzable substrate analog
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Catalysis-associated conformat ...... -hydrolyzable substrate analog
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prefLabel
Catalysis-associated conformat ...... -hydrolyzable substrate analog
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Catalysis-associated conformat ...... -hydrolyzable substrate analog
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Catalysis-associated conformat ...... -hydrolyzable substrate analog
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Catalysis-associated conformat ...... -hydrolyzable substrate analog
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P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P698