Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat - Test2 - elhamkhani - TriplyDB

Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat

Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat

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The potential of ¹¹C-acetate PET for monitoring the Fatty acid synthesis pathway in Tumors The crystal structure of a mammalian fatty acid synthase Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesis Crystal structure of FAS thioesterase domain with polyunsaturated fatty acyl adduct and inhibition by dihomo- -linolenic acid Crystal structure of the human fatty acid synthase enoyl-acyl carrier protein-reductase domain complexed with triclosan reveals allosteric protein-protein interface inhibition Mycobacterium tuberculosis Rv3802c encodes a phospholipase/thioesterase and is inhibited by the antimycobacterial agent tetrahydrolipstatin Tetrahydrolipstatin inhibition, functional analyses, and three-dimensional structure of a lipase essential for mycobacterial viability Keys to Lipid Selection in Fatty Acid Amide Hydrolase Catalysis: Structural Flexibility, Gating Residues and Multiple Binding Pockets Mechanism of Orlistat Hydrolysis by the Thioesterase of Human Fatty Acid Synthase.A concise, phosphate-mediated approach to the total synthesis of (-)-tetrahydrolipstatin.Biochemistry, molecular biology, and pharmacology of fatty acid synthase, an emerging therapeutic target and diagnosis/prognosis marker.Parasite-based screening and proteome profiling reveal orlistat, an FDA-approved drug, as a potential anti Trypanosoma brucei agent.Combining cross-metathesis and activity-based protein profiling: new β-lactone motifs for targeting serine hydrolases Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay.Repositioning proton pump inhibitors as anticancer drugs by targeting the thioesterase domain of human fatty acid synthase How lipidomics provides new insight into drug discovery.The metabolic serine hydrolases and their functions in mammalian physiology and disease.Fatty acid synthase as a potential therapeutic target in cancer.Crystal Structure and Substrate Specificity of Human Thioesterase 2: INSIGHTS INTO THE MOLECULAR BASIS FOR THE MODULATION OF FATTY ACID SYNTHASE Estimation of Hydrogen-Exchange Protection Factors from MD Simulation Based on Amide Hydrogen Bonding Analysis.Body Mass Index and Metastatic Renal Cell Carcinoma: Clinical and Biological Correlations.A strategy for dual inhibition of the proteasome and fatty acid synthase with belactosin C-orlistat hybrids.Ceftriaxone, an FDA-approved cephalosporin antibiotic, suppresses lung cancer growth by targeting Aurora B.Polyketide Ring Expansion Mediated by a Thioesterase, Chain Elongation and Cyclization Domain, in Azinomycin Biosynthesis: Characterization of AziB and AziG.Quantitation of fatty acyl-coenzyme As in mammalian cells by liquid chromatography-electrospray ionization tandem mass spectrometry Development of a Self-Assembled Nanoparticle Formulation of Orlistat, Nano-ORL, with Increased Cytotoxicity against Human Tumor Cell Lines.In vivo incorporation of unnatural amino acids to probe structure, dynamics, and ligand binding in a large protein by nuclear magnetic resonance spectroscopy.Fatty acid synthase inhibitors: new directions for oncology.Targeting lipid esterases in mycobacteria grown under different physiological conditions using activity-based profiling with tetrahydrolipstatin (THL).Current understanding of fatty acid biosynthesis and the acyl carrier protein.Structure and function of eukaryotic fatty acid synthases.Inhibitors of fatty acid synthesis in prokaryotes and eukaryotes as anti-infective, anticancer and anti-obesity drugs.Fatty acid biosynthesis revisited: structure elucidation and metabolic engineering.Synthesis of novel beta-lactone inhibitors of fatty acid synthase.Fatty Acids and Breast Cancer: Make Them on Site or Have Them Delivered.Lipid catabolism via CPT1 as a therapeutic target for prostate cancer.Recent advances in targeting the fatty acid biosynthetic pathway using fatty acid synthase inhibitors.Comparative docking of dual conformations in human fatty acid synthase thioesterase domain reveals potential binding cavity for virtual screening of ligands.Inhibition of the thioesterase activity of human fatty acid synthase by 1,4- and 9,10-diones.Analysis of the Sequences, Structures, and Functions of Product-Releasing Enzyme Domains in Fungal Polyketide Synthases.

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P2860

Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat

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2007 nî lūn-bûn

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2007 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

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2007 թվականի օգոստոսին հրատարակված գիտական հոդված

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Crystal structure of the thioe ...... synthase inhibited by Orlistat

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Crystal structure of the thioe ...... synthase inhibited by Orlistat

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Crystal structure of the thioe ...... synthase inhibited by Orlistat

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Crystal structure of the thioe ...... synthase inhibited by Orlistat

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Crystal structure of the thioe ...... synthase inhibited by Orlistat

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Crystal structure of the thioe ...... synthase inhibited by Orlistat

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Nature Structural & Molecular Biology

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Crystal structure of the thioe ...... synthase inhibited by Orlistat

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Charles W Pemble

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Lynnette C Johnson

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Steven J Kridel

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W Todd Lowther

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P2860

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

Coot: model-building tools for molecular graphics

PRODRG: a tool for high-throughput crystallography of protein-ligand complexes

Likelihood-enhanced fast translation functions

The finer things in X-ray diffraction data collection

MOLPROBITY: structure validation and all-atom contact analysis for nucleic acids and their complexes

Refinement of macromolecular structures by the maximum-likelihood method

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Structure and molecular organization of mammalian fatty acid synthase

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8

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crystal structure