Structural insight into the mechanism of substrate specificity and catalytic activity of an HD-domain phosphohydrolase: the 5'-deoxyribonucleotidase YfbR from Escherichia coli.
about
SAMHD1-deficient CD14+ cells from individuals with Aicardi-Goutières syndrome are highly susceptible to HIV-1 infectionMutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune responseMechanism of allosteric activation of SAMHD1 by dGTPGenome annotation and intraviral interactome for the Streptococcus pneumoniae virulent phage Dp-1SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by VpxSAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphatesAicardi-Goutieres syndrome and related phenotypes: linking nucleic acid metabolism with autoimmunityA metazoan ortholog of SpoT hydrolyzes ppGpp and functions in starvation responsesCharacterization of the Deoxynucleotide Triphosphate Triphosphohydrolase (dNTPase) Activity of the EF1143 Protein from Enterococcus faecalis and Crystal Structure of the Activator-Substrate ComplexStructural and Biochemical Analysis of Nuclease Domain of Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated Protein 3 (Cas3)The Structure of an Unconventional HD-GYP Protein from Bdellovibrio Reveals the Roles of Conserved Residues in this Class of Cyclic-di-GMP PhosphodiesterasesCrystal structure of an HD-GYP domain cyclic-di-GMP phosphodiesterase reveals an enzyme with a novel trinuclear catalytic iron centreOrganophosphonate-degrading PhnZ reveals an emerging family of HD domain mixed-valent diiron oxygenasesTwo duplicated genes DDI2 and DDI3 in budding yeast encode a cyanamide hydratase and are induced by cyanamideC-di-GMP hydrolysis by Pseudomonas aeruginosa HD-GYP phosphodiesterases: analysis of the reaction mechanism and novel roles for pGpGPyrimidine Salvage Enzymes Are Essential for De Novo Biosynthesis of Deoxypyrimidine Nucleotides in Trypanosoma bruceiComparative genomics of Geobacter chemotaxis genes reveals diverse signaling function.Purification, crystallization and preliminary X-ray analysis of a putative nucleotide phosphohydrolase, YpgQ, from Bacillus subtilis.Non-identity-mediated CRISPR-bacteriophage interaction mediated via the Csy and Cas3 proteins.Divergence and convergence in enzyme evolution.Positive evolutionary selection of an HD motif on Alzheimer precursor protein orthologues suggests a functional role.Contribution of SAM and HD domains to retroviral restriction mediated by human SAMHD1.Nuclease activity of the human SAMHD1 protein implicated in the Aicardi-Goutieres syndrome and HIV-1 restriction.Development of monoclonal antibodies specifically recognizing the endogenous sterile alpha motif and HD domain 1 protein in porcine cell lines.An HD-domain phosphodiesterase mediates cooperative hydrolysis of c-di-AMP to affect bacterial growth and virulence.Structure and activity of the Cas3 HD nuclease MJ0384, an effector enzyme of the CRISPR interferenceDeoxycytidine production by a metabolically engineered Escherichia coli strain.RNA damage in biological conflicts and the diversity of responding RNA repair systemsRole of SAMHD1 nuclear localization in restriction of HIV-1 and SIVmac.An HD domain phosphohydrolase active site tailored for oxetanocin-A biosynthesisCellular and Biochemical Mechanisms of the Retroviral Restriction Factor SAMHD1.SAMHD1: a new insight into HIV-1 restriction in myeloid cellsRestricted access to myeloid cells explained.The Escherichia coli Cryptic Prophage Protein YfdR Binds to DnaA and Initiation of Chromosomal Replication Is Inhibited by Overexpression of the Gene Cluster yfdQ-yfdR-yfdS-yfdTCharacterization of Runella slithyformis HD-Pnk, a bifunctional DNA/RNA end-healing enzyme composed of an N-terminal 2',3' -phosphoesterase HD domain and a C-terminal 5' -OH polynucleotide kinase domain.Mutagenesis and functional characterization of the four domains of GlnD, a bifunctional nitrogen sensor protein.Structure-based functional inference of hypothetical proteins from Mycoplasma hyopneumoniae.Helicase dissociation and annealing of RNA-DNA hybrids by Escherichia coli Cas3 protein.SAMHD1: Recurring roles in cell cycle, viral restriction, cancer, and innate immunity.
P2860
Q21089603-91BFF56F-644A-4541-BF25-F216E5BEF47BQ24338296-2208BB9F-7921-4449-BA88-F57498BF04B2Q24338757-FA7C3E63-9207-45A4-96D7-F4D467B57E07Q24600699-291B95C9-5223-4FAB-8C33-F88FDCD8D6AFQ24605940-D1DBCC08-B705-413B-A2D6-577A870BAED6Q24624362-D736C32E-6068-4F12-B454-148089DFA2BDQ24655886-3A8E0884-FE99-425C-9381-B4B3256E36D2Q27664277-86672BDA-009C-4E20-8BC6-20A83E4DC192Q27670794-B6D07F9E-087A-4078-B77D-41DDAC4A0D8DQ27670901-B2604351-1722-4DB7-9A07-2426C241DEE6Q27674977-4C61702F-4CA3-45E4-AE52-1B06033ACC29Q27680495-32CC4512-ACBB-4677-BA38-17DF5074D394Q27680548-1BFBD652-4AB9-4371-AE0D-8A03CD9ECA6CQ27939368-9487D552-02AD-4A43-9742-93E99D38725DQ28533508-A9DFAFAC-D7C1-45EC-A28D-1D29E7D020D4Q28553225-0B83664A-92D1-4F94-BD4D-36C346FBD50CQ30849005-8305F224-0CED-48CF-920C-39BD53035579Q33872900-E0462354-0DB4-4958-AF0F-D91D838CA2CBQ34026073-9F0D81CF-4C25-4474-BACD-5EA9E090D44BQ34070421-67F8BF48-38BE-4BE8-A8C1-61B380DE605FQ34154430-9DC7F2F5-0823-488D-89EF-3B9E5B77FA6FQ34312205-4F7E1044-ECE0-41CF-BCB7-83F1545FAE7AQ34325381-E3260E42-13B4-418D-980F-71FD4052446AQ34437244-09C27A78-A2D4-448B-A45B-1FE8F8CCBE94Q35128803-A6058961-F8F3-42D1-8262-72FE8907314EQ35626315-F88F1332-5BBC-4FAD-96B2-2918CBFAB276Q35819264-5438599E-3B76-46B3-B614-9FAE5C7C00CBQ36106467-EC739CB7-4B94-43D9-8983-BBD967BC5AC6Q36136752-6C744176-36F8-4E46-8DF6-B4838514ADD6Q37474015-09CEC172-33EC-4B22-828F-A3CACB216CB8Q37571689-8B63D8A5-198F-4599-9A38-9C87DC91F167Q37899283-3243D93C-6B86-43C5-8306-74A4BD90BD2BQ37945243-A4A5C851-ABF8-4CFF-99E8-2A8CC0DE5FA6Q38747435-DDC1A7CD-D581-4A04-8FD5-CBE60ED69ED6Q39147497-AD8F7650-35F8-480D-B4CA-282CA08F85F5Q40752827-3E172215-89AA-4236-8C94-F3481D2A718BQ42141891-D95891E9-DAB1-48EF-B261-30DB87121742Q52422434-5BFA1A4A-82BF-490F-B8AE-3AE50AE90A60Q52723862-3278A139-9B20-4124-8EF3-E6AFC1EFF9DA
P2860
Structural insight into the mechanism of substrate specificity and catalytic activity of an HD-domain phosphohydrolase: the 5'-deoxyribonucleotidase YfbR from Escherichia coli.
description
2008 nî lūn-bûn
@nan
2008 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մարտին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Structural Insight into the Me ...... ase YfbR from Escherichia coli
@nl
Structural insight into the me ...... se YfbR from Escherichia coli.
@ast
Structural insight into the me ...... se YfbR from Escherichia coli.
@en
type
label
Structural Insight into the Me ...... ase YfbR from Escherichia coli
@nl
Structural insight into the me ...... se YfbR from Escherichia coli.
@ast
Structural insight into the me ...... se YfbR from Escherichia coli.
@en
prefLabel
Structural Insight into the Me ...... ase YfbR from Escherichia coli
@nl
Structural insight into the me ...... se YfbR from Escherichia coli.
@ast
Structural insight into the me ...... se YfbR from Escherichia coli.
@en
P2860
P50
P3181
P1476
Structural insight into the me ...... se YfbR from Escherichia coli.
@en
P2093
Michael Proudfoot
P2860
P304
P3181
P356
10.1016/J.JMB.2008.02.036
P407
P577
2008-03-04T00:00:00Z