Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants
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A generic system for the expression and purification of soluble and stable influenza neuraminidaseNew class of monoclonal antibodies against severe influenza: prophylactic and therapeutic efficacy in ferretsSystematic review of influenza resistance to the neuraminidase inhibitorsHeterosubtypic neutralizing monoclonal antibodies cross-protective against H5N1 and H1N1 recovered from human IgM+ memory B cellsHedging against antiviral resistance during the next influenza pandemic using small stockpiles of an alternative chemotherapyEffect of neuraminidase inhibitor-resistant mutations on pathogenicity of clade 2.2 A/Turkey/15/06 (H5N1) influenza virus in ferretsMolecular dynamics simulations suggest that electrostatic funnel directs binding of Tamiflu to influenza N1 neuraminidases.Structural Basis of the Influenza A Virus RNA Polymerase PB2 RNA-binding Domain Containing the Pathogenicity-determinant Lysine 627 ResidueStructural and Functional Basis of Resistance to Neuraminidase Inhibitors of Influenza B VirusesH1N1 2009 Pandemic Influenza Virus: Resistance of the I223R Neuraminidase Mutant Explained by Kinetic and Structural AnalysisStructural and Functional Analysis of Laninamivir and its Octanoate Prodrug Reveals Group Specific Mechanisms for Influenza NA InhibitionInduced opening of influenza virus neuraminidase N2 150-loop suggests an important role in inhibitor bindingCrystal structure of a new benzoic acid inhibitor of influenza neuraminidase bound with a new tilt induced by overpacking subsite C6Functional and Structural Analysis of Influenza Virus Neuraminidase N3 Offers Further Insight into the Mechanisms of Oseltamivir ResistanceStructural basis for a class of nanomolar influenza A neuraminidase inhibitorsInfluenza neuraminidase operates via a nucleophilic mechanism and can be targeted by covalent inhibitorsMechanism-based covalent neuraminidase inhibitors with broad-spectrum influenza antiviral activityMolecular simulations of carbohydrates and protein-carbohydrate interactions: motivation, issues and prospectsSerendipitous discovery of a potent influenza virus a neuraminidase inhibitorNew small-molecule drug design strategies for fighting resistant influenza AInfluenza neuraminidase inhibitors: antiviral action and mechanisms of resistanceEnhanced mammalian transmissibility of seasonal influenza A/H1N1 viruses encoding an oseltamivir-resistant neuraminidaseMolecular modeling of swine influenza A/H1N1, Spanish H1N1, and avian H5N1 flu N1 neuraminidases bound to Tamiflu and RelenzaMutation analysis of 2009 pandemic influenza A(H1N1) viruses collected in Japan during the peak phase of the pandemicAnti-influenza activity of marchantins, macrocyclic bisbibenzyls contained in liverwortsQuantitative predictions of binding free energy changes in drug-resistant influenza neuraminidaseExploring the mechanism of zanamivir resistance in a neuraminidase mutant: a molecular dynamics studyThe cost effectiveness of pandemic influenza interventions: a pandemic severity based analysisParallel screening of wild-type and drug-resistant targets for anti-resistance neuraminidase inhibitorsThe influence of 150-cavity binders on the dynamics of influenza A neuraminidases as revealed by molecular dynamics simulations and combined clusteringI222 Neuraminidase mutations further reduce oseltamivir susceptibility of Indonesian Clade 2.1 highly pathogenic Avian Influenza A(H5N1) virusesResistance mutation R292K is induced in influenza A(H6N2) virus by exposure of infected mallards to low levels of oseltamivirInfluenza virus drug resistance: a time-sampled population genetics perspectiveEmergence and pandemic potential of swine-origin H1N1 influenza virusResistance to Mutant Group 2 Influenza Virus Neuraminidases of an Oseltamivir-Zanamivir Hybrid Inhibitor.Antiviral susceptibility of highly pathogenic avian influenza A(H5N1) viruses isolated from poultry, Vietnam, 2009-2011.Avian influenza A H5N1 virus: a continuous threat to humans.Neuraminidase inhibitor resistance after oseltamivir treatment of acute influenza A and B in children.Drug resistance in influenza A virus: the epidemiology and management.Molecular distribution of amino acid substitutions on neuraminidase from the 2009 (H1N1) human influenza pandemic virus.
P2860
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P2860
Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants
@ast
Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants
@en
Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants
@nl
type
label
Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants
@ast
Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants
@en
Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants
@nl
prefLabel
Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants
@ast
Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants
@en
Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants
@nl
P2093
P3181
P356
P1433
P1476
Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants
@en
P2093
Alan J Hay
John J Skehel
Lesley F Haire
Patrick J Collins
Philip A Walker
Rupert J Russell
Stephen R Martin
P2888
P304
P3181
P356
10.1038/NATURE06956
P407
P577
2008-05-14T00:00:00Z
P5875
P6179
1001111775