Mechanistic and functional insights into fatty acid activation in Mycobacterium tuberculosis
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Structure of a Eukaryotic Nonribosomal Peptide Synthetase Adenylation Domain That Activates a Large Hydroxamate Amino Acid in Siderophore BiosynthesisStructural and Functional Studies of Fatty Acyl Adenylate Ligases from E. coli and L. pneumophilaStructural Basis of the Interaction of MbtH-like Proteins, Putative Regulators of Nonribosomal Peptide Biosynthesis, with Adenylating EnzymesStructures of Mycobacterium tuberculosis FadD10 Protein Reveal a New Type of Adenylate-forming EnzymeNonprocessive [2 + 2]e- off-loading reductase domains from mycobacterial nonribosomal peptide synthetasesDissecting the role of critical residues and substrate preference of a Fatty Acyl-CoA Synthetase (FadD13) of Mycobacterium tuberculosisCrowd sourcing a new paradigm for interactome driven drug target identification in Mycobacterium tuberculosisIdentification of functional differences in metabolic networks using comparative genomics and constraint-based modelsEquilibrium binding and kinetic characterization of putative tetracycline repressor family transcription regulator Fad35R from Mycobacterium tuberculosisMycolic acid cyclopropanation is essential for viability, drug resistance, and cell wall integrity of Mycobacterium tuberculosisEstablishment and validation of whole-cell based fluorescence assays to identify anti-mycobacterial compounds using the Acanthamoeba castellanii-Mycobacterium marinum host-pathogen systemAn acyl-CoA synthetase in Mycobacterium tuberculosis involved in triacylglycerol accumulation during dormancyDiarylcoumarins inhibit mycolic acid biosynthesis and kill Mycobacterium tuberculosis by targeting FadD32Genome scale prediction of substrate specificity for acyl adenylate superfamily of enzymes based on active site residue profiles.A high-throughput screening fluorescence polarization assay for fatty acid adenylating enzymes in Mycobacterium tuberculosis.Oleoyl coenzyme A regulates interaction of transcriptional regulator RaaS (Rv1219c) with DNA in mycobacteria.General platform for systematic quantitative evaluation of small-molecule permeability in bacteria.Adenylate-forming enzymes.Designed Small-Molecule Inhibitors of the Anthranilyl-CoA Synthetase PqsA Block Quinolone Biosynthesis in Pseudomonas aeruginosaMicroarray expression profile analysis of mRNAs and long non-coding RNAs in pulmonary tuberculosis with different traditional Chinese medicine syndromesRetrobiosynthetic approach delineates the biosynthetic pathway and the structure of the acyl chain of mycobacterial glycopeptidolipids.Stable analogues of OSB-AMP: potent inhibitors of MenE, the o-succinylbenzoate-CoA synthetase from bacterial menaquinone biosynthesisMetabolic engineering of microorganisms for the production of structurally diverse esters.Crystal structure of FadD32, an enzyme essential for mycolic acid biosynthesis in mycobacteria.Characterization and engineering of the biosynthesis gene cluster for antitumor macrolides PM100117 and PM100118 from a marine actinobacteria: generation of a novel improved derivativeAdenylating enzymes in Mycobacterium tuberculosis as drug targets.Conformational dynamics in the Acyl-CoA synthetases, adenylation domains of non-ribosomal peptide synthetases, and firefly luciferase.Advances In Mycobacterium Tuberculosis Therapeutics Discovery Utlizing Structural Biology.Biosynthesis of mycobacterial lipids by polyketide synthases and beyond.Structures of the N-terminal domain of PqsA in complex with anthraniloyl- and 6-fluoroanthraniloyl-AMP: substrate activation in Pseudomonas Quinolone Signal (PQS) biosynthesis.Designed semisynthetic protein inhibitors of Ub/Ubl E1 activating enzymes.Insight into Structure-Function Relationships and Inhibition of the Fatty Acyl-AMP Ligase (FadD32) Orthologs from Mycobacteria.Identification of Middle Chain Fatty Acyl-CoA Ligase Responsible for the Biosynthesis of 2-Alkylmalonyl-CoAs for Polyketide Extender Unit.Structure of the Essential Mtb FadD32 Enzyme: A Promising Drug Target for Treating Tuberculosis.Cylindrocyclophane biosynthesis involves functionalization of an unactivated carbon center.Fatty Acyl Incorporation in the Biosynthesis of WAP-8294A, a Group of Potent Anti-MRSA Cyclic Lipodepsipeptides.A continuous kinetic assay for adenylation enzyme activity and inhibition.Versatility of acyl-acyl carrier protein synthetases.Detection of Delta-like 1 ligand for the diagnosis of tuberculous meningitis: An effective and rapid diagnostic method.The crystal structure of the adenylation enzyme VinN reveals a unique β-amino acid recognition mechanism.
P2860
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P2860
Mechanistic and functional insights into fatty acid activation in Mycobacterium tuberculosis
description
2009 nî lūn-bûn
@nan
2009 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մարտին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Mechanistic and functional ins ...... in Mycobacterium tuberculosis
@ast
Mechanistic and functional ins ...... in Mycobacterium tuberculosis
@en
Mechanistic and functional ins ...... in Mycobacterium tuberculosis
@nl
type
label
Mechanistic and functional ins ...... in Mycobacterium tuberculosis
@ast
Mechanistic and functional ins ...... in Mycobacterium tuberculosis
@en
Mechanistic and functional ins ...... in Mycobacterium tuberculosis
@nl
prefLabel
Mechanistic and functional ins ...... in Mycobacterium tuberculosis
@ast
Mechanistic and functional ins ...... in Mycobacterium tuberculosis
@en
Mechanistic and functional ins ...... in Mycobacterium tuberculosis
@nl
P2093
P2860
P50
P921
P356
P1476
Mechanistic and functional ins ...... in Mycobacterium tuberculosis
@en
P2093
Aneesh Goyal
Anil Tyagi
Eerappa Rajakumara
Malikmohamed Yousuf
Omita A Trivedi
Priyanka Verma
Radhika Gupta
Rajesh S Gokhale
Vivek T Natarajan
P2860
P2888
P304
P356
10.1038/NCHEMBIO.143
P577
2009-03-01T00:00:00Z
P5875
P6179
1044134422