Discovery and optimization of piperidyl benzamide derivatives as a novel class of 11beta-HSD1 inhibitors

Discovery and optimization of piperidyl benzamide derivatives as a novel class of 11beta-HSD1 inhibitors

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http://www.wikidata.org/entity/Q27653807
Structure-activity relationship of an ozonide carboxylic acid (OZ78) against Fasciola hepatica.Substrate binding process and mechanistic functioning of type 1 11β-hydroxysteroid dehydrogenase from enhanced sampling methods.Human hydroxysteroid dehydrogenases and pre-receptor regulation: insights into inhibitor design and evaluation.Identification of important chemical features of 11β-hydroxysteroid dehydrogenase type1 inhibitors: application of ligand based virtual screening and density functional theoryCrystal structures of 11β-hydroxysteroid dehydrogenase type 1 and their use in drug discovery.Evaluation of pregnane X receptor (PXR)-mediated CYP3A4 drug-drug interactions in drug development.Induction of human cytochrome P450 3A4 by the irreversible myeloperoxidase inactivator PF-06282999 is mediated by the pregnane X receptor.Development of a credible 3D-QSAR CoMSIA model and docking studies for a series of triazoles and tetrazoles containing 11β-HSD1 inhibitors.
P2860

Discovery and optimization of piperidyl benzamide derivatives as a novel class of 11beta-HSD1 inhibitors

Item
http://www.wikidata.org/entity/Q27653807
description
2009 nî lūn-bûn
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2009 թուականի Մարտին հրատարակուած գիտական յօդուած
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2009 թվականի մարտին հրատարակված գիտական հոդված
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2009年の論文
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2009年論文
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2009年論文
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2009年論文
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2009年論文
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2009年論文
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2009年论文
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Discovery and optimization of ...... lass of 11beta-HSD1 inhibitors
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Discovery and optimization of ...... lass of 11beta-HSD1 inhibitors
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Discovery and optimization of ...... lass of 11beta-HSD1 inhibitors
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Discovery and optimization of ...... lass of 11beta-HSD1 inhibitors
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Discovery and optimization of ...... lass of 11beta-HSD1 inhibitors
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Discovery and optimization of ...... lass of 11beta-HSD1 inhibitors
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Discovery and optimization of ...... lass of 11beta-HSD1 inhibitors
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Discovery and optimization of ...... lass of 11beta-HSD1 inhibitors
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Discovery and optimization of ...... lass of 11beta-HSD1 inhibitors
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Discovery and optimization of ...... lass of 11beta-HSD1 inhibitors
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10.1016/J.BMCL.2009.01.058
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