Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases
about
DNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg2+-mediated dynamic bending of gate-DNADrugging topoisomerases: lessons and challengesStructural basis of gate-DNA breakage and resealing by type II topoisomerasesCrystal structure of the DNA gyrase GyrA N-terminal domain fromMycobacterium tuberculosisA crystal structure of the bifunctional antibiotic simocyclinone D8, bound to DNA gyraseA domain insertion in Escherichia coli GyrB adopts a novel fold that plays a critical role in gyrase functionStructural basis of quinolone inhibition of type IIA topoisomerases and target-mediated resistanceStructural Insights into the Quinolone Resistance Mechanism of Mycobacterium tuberculosis DNA GyraseStructural insights into quinolone antibiotic resistance mediated by pentapeptide repeat proteins: conserved surface loops direct the activity of a Qnr protein from a Gram-negative bacteriumStructure of QnrB1, a Plasmid-mediated Fluoroquinolone Resistance FactorStructural basis of type II topoisomerase inhibition by the anticancer drug etoposideThe Structure of DNA-Bound Human Topoisomerase II Alpha: Conformational Mechanisms for Coordinating Inter-Subunit Interactions with DNA CleavageStructure of a topoisomerase II–DNA–nucleotide complex reveals a new control mechanism for ATPase activityStructure of an 'open' clamp type II topoisomerase-DNA complex provides a mechanism for DNA capture and transportOn the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugsUnderstanding the structural mechanisms of antibiotic resistance sets the platform for new discoveryNew insights into fluoroquinolone resistance in Mycobacterium tuberculosis: functional genetic analysis of gyrA and gyrB mutationsApplication of a novel microtitre plate-based assay for the discovery of new inhibitors of DNA gyrase and DNA topoisomerase VIDeletion of TnAbaR23 results in both expected and unexpected antibiogram changes in a multidrug-resistant Acinetobacter baumannii strainExploring the active site of the Streptococcus pneumoniae topoisomerase IV-DNA cleavage complex with novel 7,8-bridged fluoroquinolonesThe ancestral role of ATP hydrolysis in type II topoisomerases: prevention of DNA double-strand breaks.Fluoroquinolone-gyrase-DNA complexes: two modes of drug binding.Combinatorially-generated library of 6-fluoroquinolone analogs as potential novel antitubercular agents: a chemometric and molecular modeling assessment.Role of the water-metal ion bridge in mediating interactions between quinolones and Escherichia coli topoisomerase IV.Quinolones: from antibiotics to autoinducers.Exploiting bacterial DNA gyrase as a drug target: current state and perspectives.Solution structures of DNA-bound gyrase.Molecular characterization of fluoroquinolone resistance in Mycobacterium tuberculosis: functional analysis of gyrA mutation at position 74.Bypassing fluoroquinolone resistance with quinazolinediones: studies of drug-gyrase-DNA complexes having implications for drug design.Use of divalent metal ions in the DNA cleavage reaction of topoisomerase IV.Direct measurement of DNA bending by type IIA topoisomerases: implications for non-equilibrium topology simplification4-Quinolones: smart phones of the microbial world.Unlinking of supercoiled DNA catenanes by type IIA topoisomerases.The dimer state of GyrB is an active form: implications for the initial complex assembly and processive strand passage.Local sensing of global DNA topology: from crossover geometry to type II topoisomerase processivityStructure based in silico analysis of quinolone resistance in clinical isolates of Salmonella Typhi from India.Drug interactions with Bacillus anthracis topoisomerase IV: biochemical basis for quinolone action and resistance.Isolation and Characterization of Antimicrobial-Resistant Nontyphoidal Salmonella enterica Serovars from Imported Food Products.Mechanisms of drug resistance: quinolone resistance.Fluoroquinolones stimulate the DNA cleavage activity of topoisomerase IV by promoting the binding of Mg(2+) to the second metal binding site.
P2860
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P2860
Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases
description
2009 nî lūn-bûn
@nan
2009 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases
@ast
Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases
@en
Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases
@nl
type
label
Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases
@ast
Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases
@en
Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases
@nl
prefLabel
Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases
@ast
Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases
@en
Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases
@nl
P2093
P2860
P3181
P356
P1476
Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases
@en
P2093
Andrew W Thompson
Dennis A Veselkov
Ivan Laponogov
Katherine E McAuley
L Mark Fisher
Maninder K Sohi
Mark R Sanderson
Ritica Sawhney
Xiao-Su Pan
P2860
P2888
P3181
P356
10.1038/NSMB.1604
P577
2009-06-01T00:00:00Z
P5875
P6179
1029322394