about
Review of the Structural and Dynamic Mechanisms of PPARγ Partial AgonismIdentification and Mechanism of 10-Carbon Fatty Acid as Modulating Ligand of Peroxisome Proliferator-activated ReceptorsOn the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal musclesCMHX008, a novel peroxisome proliferator-activated receptor γ partial agonist, enhances insulin sensitivity in vitro and in vivoMinireview: Challenges and opportunities in development of PPAR agonistsSelective Tissue Distribution Mediates Tissue-Dependent PPARγ Activation and Insulin Sensitization by INT131, a Selective PPARγ Modulator.Peroxisome proliferator-activated receptor-(gamma) receptor ligand partially prevents the development of endometrial explants in baboons: a prospective, randomized, placebo-controlled study.Selective PPARγ modulator INT131 normalizes insulin signaling defects and improves bone mass in diet-induced obese mice.Noncanonical mechanisms to regulate nuclear receptor signaling.Synthesis of N-(6-(4-(Piperazin-1-yl)phenoxy)pyridin-3-yl)benzenesulfonamide Derivatives for the Treatment of Metabolic Syndrome.Pharmacokinetics, efficacy and safety of aleglitazar for the treatment of type 2 diabetes with high cardiovascular risk.Pharmacophore modeling improves virtual screening for novel peroxisome proliferator-activated receptor-gamma ligands.N-Acetylfarnesylcysteine is a novel class of peroxisome proliferator-activated receptor γ ligand with partial and full agonist activity in vitro and in vivo.Peroxisome Proliferator-Activated Receptors and the Heart: Lessons from the Past and Future Directions.Small molecule modulation of nuclear receptor conformational dynamics: implications for function and drug discoveryAllosteric Pathways in the PPARγ-RXRα nuclear receptor complex.SR2067 Reveals a Unique Kinetic and Structural Signature for PPARγ Partial Agonism.Pseudoginsenoside F11, a Novel Partial PPAR γ Agonist, Promotes Adiponectin Oligomerization and Secretion in 3T3-L1 AdipocytesDiscovery and development of selective PPAR gamma modulators as safe and effective antidiabetic agents.Structure-Activity Relationship of 2,4-Dichloro-N-(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide (INT131) Analogs for PPARγ-Targeted Antidiabetics.An alternate binding site for PPARγ ligandsPPARs in the central nervous system: roles in neurodegeneration and neuroinflammation.Comparative molecular profiling of the PPARα/γ activator aleglitazar: PPAR selectivity, activity and interaction with cofactors.KDT501, a derivative from hops, normalizes glucose metabolism and body weight in rodent models of diabetesInvestigations on Binding Pattern of Kinase Inhibitors with PPARγ: Molecular Docking, Molecular Dynamic Simulations, and Free Energy Calculation Studies.Tectorigenin regulates adipogenic differentiation and adipocytokines secretion via PPARγ and IKK/NF-κB signaling.SAR and Computer-Aided Drug Design Approaches in the Discovery of Peroxisome Proliferator-Activated ReceptorγActivators: A Perspective
P2860
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P2860
description
2009 nî lūn-bûn
@nan
2009 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մարտին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
INT131: a selective modulator of PPAR gamma
@ast
INT131: a selective modulator of PPAR gamma
@en
INT131: a selective modulator of PPAR gamma
@nl
type
label
INT131: a selective modulator of PPAR gamma
@ast
INT131: a selective modulator of PPAR gamma
@en
INT131: a selective modulator of PPAR gamma
@nl
prefLabel
INT131: a selective modulator of PPAR gamma
@ast
INT131: a selective modulator of PPAR gamma
@en
INT131: a selective modulator of PPAR gamma
@nl
P2093
P1476
INT131: a selective modulator of PPAR gamma
@en
P2093
Alykhan Motani
Donna H T Biermann
Helen Fuentes
Jennifer Weiszmann
Jin-Long Chen
Jinsong Liu
Jocelyn Staunton
Lawrence R McGee
P304
P356
10.1016/J.JMB.2009.01.025
P407
P577
2009-03-13T00:00:00Z