Structural basis of serine/threonine phosphatase inhibition by the archetypal small molecules cantharidin and norcantharidin
about
Norcantharidin analogues: a patent review (2006 - 2010).Viewing serine/threonine protein phosphatases through the eyes of drug designersInsights into the key interactions between human protein phosphatase 5 and cantharidin using molecular dynamics and site-directed mutagenesis bioassays.Folate receptor-targeted liposomes loaded with a diacid metabolite of norcantharidin enhance antitumor potency for H22 hepatocellular carcinoma both in vitro and in vivo.Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C.Structure-Activity Relationship Studies Using Natural and Synthetic Okadaic Acid/Dinophysistoxin Toxins.The phosphoprotein phosphatase family of Ser/Thr phosphatases as principal targets of naturally occurring toxins.Terpenoids: natural products for cancer therapy.Cantharidin-based small molecules as potential therapeutic agents.Deprotonation states of the two active site water molecules regulate the binding of protein phosphatase 5 with its substrate: a molecular dynamics study.Cantharidin inhibits competitively heme-Fe(III) binding to the FA1 site of human serum albumin.Norcantharidin inhibits the expression of extracellular matrix and TGF-β1 in HK-2 cells induced by high glucose independent of calcineurin signal pathway.Synthesis and Biological Evaluation of Norcantharidin Derivatives Possessing an Aromatic Amine Moiety as Antifungal Agents.Exploration of new drug-like inhibitors for serine/threonine protein phosphatase 5 of Plasmodium falciparum: a docking and simulation study.Non-target effects on soil microbial parameters of the synthetic pesticide carbendazim with the biopesticides cantharidin and norcantharidin.Cantharidin impedes the activity of protein serine/threonine phosphatase in Plutella xylostella.Molecular cloning and characterization of the calcineurin subunit A from Plutella xylostella.Cantharidin and its anhydride-modified derivatives: relation of structure to insecticidal activityAn unexpected formation of the novel 7-oxa-2-azabicyclo[2.2.1]hept-5-ene skeleton during the reaction of furfurylamine with maleimides and their bioprospection using a zebrafish embryo model.Determination and pharmacokinetic study of the diacid metabolite of norcantharidin in beagle plasma by use of liquid chromatography-tandem mass spectrometry.Modeling the antiferromagnetic MnIIMnII system within the protein phosphatase-5 catalytic site.An Ultra-High-Throughput Screen for Catalytic Inhibitors of Serine/Threonine Protein Phosphatases Types 1 and 5 (PP1C and PP5C)
P2860
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P2860
Structural basis of serine/threonine phosphatase inhibition by the archetypal small molecules cantharidin and norcantharidin
description
2009 nî lūn-bûn
@nan
2009 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Structural basis of serine/thr ...... cantharidin and norcantharidin
@ast
Structural basis of serine/thr ...... cantharidin and norcantharidin
@en
Structural basis of serine/thr ...... cantharidin and norcantharidin
@nl
type
label
Structural basis of serine/thr ...... cantharidin and norcantharidin
@ast
Structural basis of serine/thr ...... cantharidin and norcantharidin
@en
Structural basis of serine/thr ...... cantharidin and norcantharidin
@nl
prefLabel
Structural basis of serine/thr ...... cantharidin and norcantharidin
@ast
Structural basis of serine/thr ...... cantharidin and norcantharidin
@en
Structural basis of serine/thr ...... cantharidin and norcantharidin
@nl
P2093
P3181
P356
P1476
Structural basis of serine/thr ...... cantharidin and norcantharidin
@en
P2093
P304
P3181
P356
10.1021/JM900610K
P407
P577
2009-08-13T00:00:00Z