Mechanism of Cyclizing NAD to Cyclic ADP-ribose by ADP-ribosyl Cyclase and CD38
about
Insights into the mechanism of bovine CD38/NAD+glycohydrolase from the X-ray structures of its Michaelis complex and covalently-trapped intermediatesMolecular bases of catalysis and ADP-ribose preference of human Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase and conversion by mutagenesis to a preferential cyclic ADP-ribose phosphohydrolaseDynamic Conformations of the CD38-Mediated NAD Cyclization Captured in a Single CrystalCD38 Structure-Based Inhibitor Design Using the N1-Cyclic Inosine 5'-Diphosphate Ribose TemplateExpression, localization, and biochemical characterization of nicotinamide mononucleotide adenylyltransferase 2Compartmentation of NAD+-dependent signalling.Cytosolic CD38 protein forms intact disulfides and is active in elevating intracellular cyclic ADP-ribosePorcine CD38 exhibits prominent secondary NAD(+) cyclase activity.Recycling nicotinamide. The transition-state structure of human nicotinamide phosphoribosyltransferase.Cyclic ADP-ribose and NAADP: fraternal twin messengers for calcium signaling.Roles of cADPR and NAADP in pancreatic cells.Cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate (NAADP) as messengers for calcium mobilization.Cyclic adenosine 5'-diphosphate ribose analogs without a "southern" ribose inhibit ADP-ribosyl cyclase-hydrolase CD38.A single residue in a novel ADP-ribosyl cyclase controls production of the calcium-mobilizing messengers cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate.Cyclic ADP-ribose requires CD38 to regulate the release of ATP in visceral smooth muscle.Aberrant cyclization affords a C-6 modified cyclic adenosine 5'-diphosphoribose analogue with biological activity in Jurkat T cells.CD38 deficiency suppresses adipogenesis and lipogenesis in adipose tissues through activating Sirt1/PPARγ signaling pathway.Second messenger analogues highlight unexpected substrate sensitivity of CD38: total synthesis of the hybrid "L-cyclic inosine 5'-diphosphate ribose".TIR Domain Proteins Are an Ancient Family of NAD+-Consuming Enzymes.The Emergence of the Nicotinamide Riboside Kinases in the regulation of NAD+ Metabolism.
P2860
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P2860
Mechanism of Cyclizing NAD to Cyclic ADP-ribose by ADP-ribosyl Cyclase and CD38
description
2009 nî lūn-bûn
@nan
2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Mechanism of Cyclizing NAD to Cyclic ADP-ribose by ADP-ribosyl Cyclase and CD38
@ast
Mechanism of Cyclizing NAD to Cyclic ADP-ribose by ADP-ribosyl Cyclase and CD38
@en
Mechanism of Cyclizing NAD to Cyclic ADP-ribose by ADP-ribosyl Cyclase and CD38
@nl
type
label
Mechanism of Cyclizing NAD to Cyclic ADP-ribose by ADP-ribosyl Cyclase and CD38
@ast
Mechanism of Cyclizing NAD to Cyclic ADP-ribose by ADP-ribosyl Cyclase and CD38
@en
Mechanism of Cyclizing NAD to Cyclic ADP-ribose by ADP-ribosyl Cyclase and CD38
@nl
prefLabel
Mechanism of Cyclizing NAD to Cyclic ADP-ribose by ADP-ribosyl Cyclase and CD38
@ast
Mechanism of Cyclizing NAD to Cyclic ADP-ribose by ADP-ribosyl Cyclase and CD38
@en
Mechanism of Cyclizing NAD to Cyclic ADP-ribose by ADP-ribosyl Cyclase and CD38
@nl
P2093
P2860
P356
P1476
Mechanism of Cyclizing NAD to Cyclic ADP-ribose by ADP-ribosyl Cyclase and CD38
@en
P2093
Hon Cheung Lee
Irina A Kriksunov
Norman Oppenheimer
Richard Graeff
P2860
P304
P356
10.1074/JBC.M109.030965
P407
P577
2009-10-02T00:00:00Z