Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase
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Crystal Structure of the 6-Hydroxymethyl-7,8-Dihydropterin Pyrophosphokinase•Dihydropteroate Synthase Bifunctional Enzyme from Francisella tularensisCrystal structures of Burkholderia cenocepacia dihydropteroate synthase in the apo-form and complexed with the product 7,8-dihydropteroateStructure of S. aureus HPPK and the Discovery of a New Substrate Site InhibitorExploring the chemical space around 8-mercaptoguanine as a route to new inhibitors of the folate biosynthesis enzyme HPPKCatalysis and Sulfa Drug Resistance in Dihydropteroate SynthaseStructure-Based Design of Novel Pyrimido[4,5-c]pyridazine Derivatives as Dihydropteroate Synthase Inhibitors with Increased AffinityThe identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinaseIdentification and characterization of an allosteric inhibitory site on dihydropteroate synthase.Structural enzymology and inhibition of the bi-functional folate pathway enzyme HPPK-DHPS from the biowarfare agent Francisella tularensisBioorganometallic chemistry with IspG and IspH: structure, function, and inhibition of the [Fe(4)S(4)] proteins involved in isoprenoid biosynthesis.New developments in vaccines, inhibitors of anthrax toxins, and antibiotic therapeutics for Bacillus anthracis.Replacing sulfa drugs with novel DHPS inhibitorsSynthesis of bi-substrate state mimics of dihydropteroate synthase as potential inhibitors and molecular probes.Development of a pterin-based fluorescent probe for screening dihydropteroate synthase.Utility of the Biosynthetic Folate Pathway for Targets in Antimicrobial Discovery.Antibacterial Antifolates: From Development through Resistance to the Next Generation8-Mercaptoguanine Derivatives as Inhibitors of Dihydropteroate Synthase.Exploring the catalytic mechanism of dihydropteroate synthase: elucidating the differences between the substrate and inhibitor.Insights into the drug resistance induced by the BaDHPS mutations: molecular dynamic simulations and MM/GBSA studies.RepTB: a gene ontology based drug repurposing approach for tuberculosis.
P2860
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P2860
Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase
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2010 nî lūn-bûn
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2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
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2010 թվականի հունվարին հրատարակված գիտական հոդված
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2010年の論文
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2010年論文
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2010年論文
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2010年論文
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2010年論文
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2010年論文
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2010年论文
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Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase
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Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase
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Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase
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Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase
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Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase
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Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase
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Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase
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Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase
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Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase
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P2093
P2860
P356
P1476
Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase
@en
P2093
Iain D Kerr
Jianjun Qi
Julian G Hurdle
Kanya Balakrishna
Kerim Babaoglu
Mi-Kyung Yun
Stephen W White
P2860
P304
P356
10.1021/JM900861D
P407
P577
2010-01-14T00:00:00Z