The 1.4 Å Crystal Structure of the Class D β-Lactamase OXA-1 Complexed with Doripenem
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Carbapenems: past, present, and futureThree decades of beta-lactamase inhibitorsBiochemical and Structural Characterization of Mycobacterium tuberculosis β-Lactamase with the Carbapenems Ertapenem and DoripenemStructures of the Michaelis Complex (1.2 Å) and the Covalent Acyl Intermediate (2.0 Å) of Cefamandole Bound in the Active Sites of the Mycobacterium tuberculosis β-Lactamase K73A and E166A Mutants,Three factors that modulate the activity of class D β-lactamases and interfere with the post-translational carboxylation of Lys70Structures of the Class D Carbapenemase OXA-24 from Acinetobacter baumannii in Complex with DoripenemLysine N -Decarboxylation Switch and Activation of the -Lactam Sensor Domain of BlaR1 Protein of Methicillin-resistant Staphylococcus aureusStructures of the Class D Carbapenemases OXA-23 and OXA-146: Mechanistic Basis of Activity against Carbapenems, Extended-Spectrum Cephalosporins, and AztreonamStructural Basis for Carbapenemase Activity of the OXA-23 β-Lactamase from Acinetobacter baumanniiCrystal Structure of Carbapenemase OXA-58 from Acinetobacter baumanniiStructure of the extended-spectrum class C β-lactamase ADC-1 fromAcinetobacter baumanniiStructural Basis for Different Substrate Profiles of Two Closely Related Class D β-Lactamases and Their Inhibition by HalogensThe structure of a doripenem-bound OXA-51 class D β-lactamase variant with enhanced carbapenemase activityClass D β-lactamases: a reappraisal after five decadesClassification of Beta-lactamases and penicillin binding proteins using ligand-centric network models.Site-saturation mutagenesis of position V117 in OXA-1 β-lactamase: effect of side chain polarity on enzyme carboxylation and substrate turnover.Structural Basis for Enhancement of Carbapenemase Activity in the OXA-51 Family of Class D β-Lactamases.Class D β-lactamases do exist in Gram-positive bacteria.Clinical Variants of the Native Class D β-Lactamase of Acinetobacter baumannii Pose an Emerging Threat through Increased Hydrolytic Activity against CarbapenemsFrom Molecular Phylogenetics to Quantum Chemistry: Discovering Enzyme Design Principles through Computation.The role of conserved surface hydrophobic residues in the carbapenemase activity of the class D β-lactamases.Acquired Class D β-Lactamases.The mechanism of NDM-1-catalyzed carbapenem hydrolysis is distinct from that of penicillin or cephalosporin hydrolysis.A New Mechanism for β-Lactamases: Class D Enzymes Degrade 1β-Methyl Carbapenems through Lactone Formation.Chemical rescue of the post-translationally carboxylated lysine mutant of allantoinase and dihydroorotase by metal ions and short-chain carboxylic acids.Network Analysis of Protein Adaptation: modeling the functional impact of multiple mutations.Magnolol restores the activity of meropenem against NDM-1-producing Escherichia coli by inhibiting the activity of metallo-beta-lactamase.A New Mechanism for β-Lactamases: Class D Enzymes Degrade 1β-Methyl Carbapenems through Lactone Formation
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P2860
The 1.4 Å Crystal Structure of the Class D β-Lactamase OXA-1 Complexed with Doripenem
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2009 nî lūn-bûn
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2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
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2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
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2009年の論文
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2009年論文
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2009年論文
@zh-hant
2009年論文
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2009年論文
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2009年論文
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2009年论文
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name
The 1.4 Å Crystal Structure of the Class D β-Lactamase OXA-1 Complexed with Doripenem
@ast
The 1.4 Å Crystal Structure of the Class D β-Lactamase OXA-1 Complexed with Doripenem
@en
The 1.4 Å Crystal Structure of the Class D β-Lactamase OXA-1 Complexed with Doripenem
@nl
type
label
The 1.4 Å Crystal Structure of the Class D β-Lactamase OXA-1 Complexed with Doripenem
@ast
The 1.4 Å Crystal Structure of the Class D β-Lactamase OXA-1 Complexed with Doripenem
@en
The 1.4 Å Crystal Structure of the Class D β-Lactamase OXA-1 Complexed with Doripenem
@nl
prefLabel
The 1.4 Å Crystal Structure of the Class D β-Lactamase OXA-1 Complexed with Doripenem
@ast
The 1.4 Å Crystal Structure of the Class D β-Lactamase OXA-1 Complexed with Doripenem
@en
The 1.4 Å Crystal Structure of the Class D β-Lactamase OXA-1 Complexed with Doripenem
@nl
P2093
P2860
P356
P1433
P1476
The 1.4 Å Crystal Structure of the Class D β-Lactamase OXA-1 Complexed with Doripenem
@en
P2093
David A Leonard
Kyle D Schneider
Mary E Karpen
Rachel A Powers
P2860
P304
P356
10.1021/BI901690R
P407
P577
2009-12-22T00:00:00Z