Mutations Abrogating VP35 Interaction with Double-Stranded RNA Render Ebola Virus Avirulent in Guinea Pigs - Test2 - elhamkhani - TriplyDB

Mutations Abrogating VP35 Interaction with Double-Stranded RNA Render Ebola Virus Avirulent in Guinea Pigs

Mutations Abrogating VP35 Interaction with Double-Stranded RNA Render Ebola Virus Avirulent in Guinea Pigs

http://www.wikidata.org/entity/Q27658947

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Unexpected inheritance: multiple integrations of ancient bornavirus and ebolavirus/marburgvirus sequences in vertebrate genomes Filoviral immune evasion mechanisms DRBP76 associates with Ebola virus VP35 and suppresses viral polymerase function Mutual antagonism between the Ebola virus VP35 protein and the RIG-I activator PACT determines infection outcome Structural and Functional Characterization of Reston Ebola Virus VP35 Interferon Inhibitory Domain Structural basis for Marburg virus VP35-mediated immune evasion mechanisms Development of RNA Aptamers Targeting Ebola Virus VP35 In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity Rescue of non-human primates from advanced Sudan ebolavirus infection with lipid encapsulated siRNA Virus nomenclature below the species level: a standardized nomenclature for filovirus strains and variants rescued from cDNA Induction and suppression of antiviral RNA interference by influenza A virus in mammalian cells The Mammalian response to virus infection is independent of small RNA silencing.Crystallization and preliminary X-ray analysis of Ebola VP35 interferon inhibitory domain mutant proteins Interplay between innate immunity and negative-strand RNA viruses: towards a rational model The Ebola virus VP24 protein prevents hnRNP C1/C2 binding to karyopherin α1 and partially alters its nuclear import.Molecular mechanisms of viral inhibitors of RIG-I-like receptors.How Ebola virus counters the interferon system.RNA interference functions as an antiviral immunity mechanism in mammals.Camouflage and misdirection: the full-on assault of ebola virus disease Ebolavirus Database: Gene and Protein Information Resource for Ebolaviruses Molecular Mechanisms of Innate Immune Inhibition by Non-Segmented Negative-Sense RNA Viruses.An upstream open reading frame modulates ebola virus polymerase translation and virus replication.Ebolavirus VP35 is a multifunctional virulence factor.Tackling Ebola: new insights into prophylactic and therapeutic intervention strategies.Marburg virus VP40 antagonizes interferon signaling in a species-specific manner.Unconventional secretion of Ebola virus matrix protein VP40.Ebola virus failure to stimulate plasmacytoid dendritic cell interferon responses correlates with impaired cellular entry.Kunjin virus replicon-based vaccines expressing Ebola virus glycoprotein GP protect the guinea pig against lethal Ebola virus infection.Recombinant Marburg virus expressing EGFP allows rapid screening of virus growth and real-time visualization of virus spread.Innate immune evasion by filoviruses The role of antigen-presenting cells in filoviral hemorrhagic fever: gaps in current knowledge.Different Temporal Effects of Ebola Virus VP35 and VP24 Proteins on Global Gene Expression in Human Dendritic Cells.Assessing the contribution of interferon antagonism to the virulence of West African Ebola viruses Soluble Glycoprotein Is Not Required for Ebola Virus Virulence in Guinea Pigs Immunological features underlying viral hemorrhagic fevers In silico and in vitro methods to identify ebola virus VP35-dsRNA inhibitors Predictive and comparative analysis of Ebolavirus proteins Topoisomerase II Inhibitors Induce DNA Damage-Dependent Interferon Responses Circumventing Ebola Virus Immune Evasion.The Ebola virus VP35 protein binds viral immunostimulatory and host RNAs identified through deep sequencing Differential Regulation of Interferon Responses by Ebola and Marburg Virus VP35 Proteins.

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P2860

Mutations Abrogating VP35 Interaction with Double-Stranded RNA Render Ebola Virus Avirulent in Guinea Pigs

http://www.wikidata.org/entity/Q27658947

description

2010 nî lūn-bûn

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2010 թուականի Մարտին հրատարակուած գիտական յօդուած

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2010 թվականի մարտին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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Mutations Abrogating VP35 Inte ...... Virus Avirulent in Guinea Pigs

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Mutations Abrogating VP35 Inte ...... Virus Avirulent in Guinea Pigs

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Mutations Abrogating VP35 Inte ...... Virus Avirulent in Guinea Pigs

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Mutations Abrogating VP35 Inte ...... Virus Avirulent in Guinea Pigs

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Mutations Abrogating VP35 Inte ...... Virus Avirulent in Guinea Pigs

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Mutations Abrogating VP35 Inte ...... Virus Avirulent in Guinea Pigs

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Christopher F Basler

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Daisy W Leung

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Kathleen C Prins

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Olivier Reynard

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Parameshwaran Ramanan

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Sebastien Delpeut

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St Patrick Reid

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Valentina A Volchkova

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P2860

Effective post-exposure treatment of Ebola infection

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

Ebola virus protein VP35 impairs the function of interferon regulatory factor-activating kinases IKKepsilon and TBK-1

MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

Structure of the Ebola VP35 interferon inhibitory domain

Structural basis for dsRNA recognition and interferon antagonism by Ebola VP35

Coot: model-building tools for molecular graphics

The finer things in X-ray diffraction data collection

Efficient selection for high-expression transfectants with a novel eukaryotic vector

Optimal description of a protein structure in terms of multiple groups undergoing TLS motion

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2299567

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10.1128/JVI.02459-09

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6

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84

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Viktor Volchkov

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Gaya K. Amarasinghe

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2010-03-01T00:00:00Z

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20071589

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2014 Ebola virus epidemic in Guinea

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2826052

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